A5029255904- Malaria Research and Control
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Smart Grid Security and Resilience
- Fault Detection and Control Systems
- Research on Leishmaniasis Studies
- High-Voltage Power Transmission Systems
- Marine Sponges and Natural Products
- Complement system in diseases
- Anomaly Detection Techniques and Applications
- Network Security and Intrusion Detection
- Cancer therapeutics and mechanisms
- Phase Change Materials Research
- Speech Recognition and Synthesis
- Mosquito-borne diseases and control
- Microbial Natural Products and Biosynthesis
- Advanced Algorithms and Applications
- Computational Drug Discovery Methods
- Traffic Prediction and Management Techniques
- Topic Modeling
- Oil and Gas Production Techniques
- Digital Media Forensic Detection
- RNA and protein synthesis mechanisms
- Wind Energy Research and Development
- Synthesis and Biological Activity
University of Science and Technology Beijing
2024-2025
Northeast Petroleum University
2025
Zhengzhou University of Aeronautics
2025
China Medical University
2023-2024
Southwest Jiaotong University
2016-2023
Chang'an University
2018
The University of Sydney
2010-2017
State Key Laboratory of Respiratory Disease
2015-2017
Chinese Academy of Sciences
2015-2017
Robert Bosch (Australia)
2011-2017
Analogues of the natural product gallinamide A were prepared to elucidate novel inhibitors falcipain cysteine proteases. exhibited potent inhibition falcipain-2 (FP-2) and falcipain-3 (FP-3) development Plasmodium falciparum in vitro. Several compounds equipotent chloroquine as 3D7 strain P. maintained activity against chloroquine-resistant Dd2 parasite. These serve promising leads for antimalarial agents.
The first total synthesis of symplostatin 4, a marine cyanobacterium-derived natural product, is described. Notable features the route include efficient preparation three key fragments and final assembly to product via sequential imide amide couplings. Symplostatin 4 was also demonstrated possess significant antimalarial activity (ED50 74 nM against Plasmodium falciparum, strain 3D7).
The total synthesis and stereochemical assignment of gallinamide A, an antimalarial depsipeptide cyanobacterial origin, is described. Synthesis the four possible N-terminal diastereoisomers A (including natural product symplostatin 4) was achieved using a divergent strategy from common imide fragment. corresponding were synthesized in 30-33% overall yield longest linear sequence 8 steps. Comparative NMR spectroscopic studies synthetic with isolated demonstrated that possesses dimethylated...
We expressed the wild-type rplC and mutated (Cys154Arg) genes, respectively, in Mycobacterium tuberculosis H37Ra H37Rv an attempt to delineate role of regarding oxazolidinone resistance. An increase MICs linezolid (LZD) sutezolid (PNU-100480, PNU) against recombinant mycobacteria with overexpressed mutation was found, suggesting gene is a determinant bacillary susceptibilities LZD PNU.
Pyrazinamide (PZA), an indispensable component of modern tuberculosis treatment, acts as a key sterilizing drug. While the mechanism activation this prodrug into pyrazinoic acid (POA) by
Anomaly detection and root cause analysis of energy consumption not only optimize use improve equipment reliability but also contribute to green low-carbon development. This paper proposes a comprehensive diagnostic framework for detecting anomalies, conducting causal analysis, tracing causes in medium heavy plate manufacturing, integrating process mechanisms, expert knowledge, industrial big data. First, two-stage anomaly method based on box plot is developed identify irregularities. Next,...
Analysing the microscopic phase transition mechanism and thermodynamic properties of process paraffin composite change materials through scale is great significance in determining heat transfer characteristics as well energy storage conversion materials. In this paper, molecular dynamics simulation experimental verification methods are used to select three models n-octadecane, n-, glycerol trimyristate establish two different phase-change material models, Various factors (Van Der Waals...
Contrastive Language-Image Pretraining (CLIP) has been widely used in vision tasks. Notably, CLIP demonstrated promising performance few-shot learning (FSL). However, existing CLIP-based methods training-free FSL (i.e., without the requirement of additional training) mainly learn different modalities independently, leading to two essential issues: 1) severe anomalous match image modality; 2) varying quality generated text prompts. To address these issues, we build a mutual guidance...
ABSTRACT The alcohol precipitation wastewater produced during the manufacture of Chinese patent medicine (CPM) was investigated in an anaerobic digestion process as a biological pre-treatment method. After 220-day debugging period, reached stability with excellent chemical oxygen demand (COD) removal rate (>85%) were achieved and influent's COD, ammonium (NH4+-N), total nitrogen (TN) concentrations 21,000, 200, 400 mg/L, respectively. microbial degradation mechanisms analyzed by 3D...
ABSTRACT This article studies the problem of finite impulse response (FIR) system identification with binary sensor and either‐or communication, together packet drop for quantized inputs. We propose online algorithms two cases known unknown probability drop, prove strong convergence asymptotic normality algorithms. Additionally, we introduce metrics to describe speed algorithm's when is unknown. Finally, effectiveness theoretical results verified by experiment.
Mycobacterium abscessus (MAB), which manifests in the pulmonary system, is one of neglected causes nontuberculous mycobacteria (NTM) infection. Treatment against MAB difficult, characterized by its intrinsic antibiotic drug resistance. Lysine acetylation can alter physiochemical property proteins living organisms. This study aimed to determine if this protein post-translational modification (PTM) exists a clinical isolate M. GZ002. We used antiacetyl-lysine immunoprecipitation enrich...
This research describes the use of novel antimalarial combinations new artemisinin derivative artemiside, a 10-alkylamino artemisinin. It is stable, highly crystalline compound that economically prepared from dihydroartemisinin in one-step process. Artemiside activity was more pronounced than any drug use, both Plasmodium falciparum culture and vivo murine malaria model depicting cerebral (CM). In vitro high-throughput testing artemiside revealed large number conventional drugs with which it...
Flotation, as one efficient waste plastic separation technology, is an effective method to improve the recycling rate of packaging waste. Polyethylene terephthalate (PET) widely used in industry, has a large number consumption and high recovery value. Aiming at separating PET from wastes, designed flotation column was laboratory investigate effects parameters, such wetting agent species concentration, on behaviors. The results showed that primary PET/polyvinyl...
Cerebral malaria (CM) is a severe complication of and leading cause death due to Plasmodium falciparum infection. CM likely the result interrelated events, including mechanical obstruction parasite sequestration in microvasculature, upregulation Th1 immune responses. In parallel, blood-brain-barrier (BBB) breakdown damage or microglia, astrocytes, neurons occurs. We found that novel formulation liposome-encapsulated glucocorticosteroid, β-methasone hemisuccinate (nSSL-BMS), prevents...
We mainly study the optimal control problem for linear cyber physical systems under replay attacks in this paper. The methodological research relies on following two starting points: (1) Promptly detect and estimate malicious attack behaviours hampering normal system procedures; (2) Design a resilient strategy to ensure regularly works as much possible. Specifically, becomes time delay after attack, then an algorithm is designed transform into delay-free its stability. Finally, numerical...
ABSTRACT The decreasing effectiveness of antimalarial therapy due to drug resistance necessitates constant efforts develop new drugs. Artemisinin derivatives are the most recent drugs that have been introduced and considered first line treatment, but there already indications Plasmodium falciparum artemisinins. Consequently, combinations recommended for prevention induction resistance. research here demonstrates effects novel artemisinin derivative, artemisone, a recently described...