A5053562146- Neurological Disease Mechanisms and Treatments
- Plant-based Medicinal Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Drug Transport and Resistance Mechanisms
- Pharmacological Effects and Toxicity Studies
- Monoclonal and Polyclonal Antibodies Research
- Biochemical effects in animals
- Curcumin's Biomedical Applications
- Chromatography in Natural Products
- Natural product bioactivities and synthesis
- Renal Diseases and Glomerulopathies
- Stroke Rehabilitation and Recovery
- Lipid metabolism and disorders
- Acute Lymphoblastic Leukemia research
- Dementia and Cognitive Impairment Research
- Glycosylation and Glycoproteins Research
- Epilepsy research and treatment
- Oral Health Pathology and Treatment
- Phytochemical Studies and Bioactivities
- Traditional Chinese Medicine Analysis
- Alzheimer's disease research and treatments
- Lung Cancer Treatments and Mutations
- Neurological Disorders and Treatments
- Cancer-related cognitive impairment studies
- Ginger and Zingiberaceae research
Guangzhou University of Chinese Medicine
2021-2022
Binzhou People's Hospital
2017-2018
Xinjiang Medical University
2011
Morin is a flavanoid which exhibits potent antioxidant activity in various oxidative stress related diseases. The current study was attempted to scrutinize the preclinical bio-efficacy of morin on focal ischemia.The animal model cerebral ischemic injury done by midbrain carotid artery occlusion (MCAO) method, followed (30mg/kg) administration for seven days.The outcome showed that treatment with displayed positive effects reducing ischemia. This effect evident improvements neurological...
Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible interstitial disease with poor prognosis. The extract of Nervilia fordii (NFE) has shown remarkable benefit in the treatment acute lung injury, cancer, severe respiratory syndrome (SARS). However, potential mechanism efficacy NFE IPF remain unknown. In this study, systematic network pharmacology analysis was used to predict IPF, based on major components elucidated by UPLC-TOF-MS/MS. molecular interactions between...
Effects of gastrodin on 5-HT and neurotrophic factor in the treatment patients with post-stroke depression (PSD) were investigated. A total 78 PSD selected Binzhou City Center Hospital from September 2013 to December 2016. Patients randomly divided into control group experimental group, 39 each group. treated conventional drug fluoxertine hydrochloride for 2 months, gastrodin. The levels factors blood measured using enzyme-linked immunosorbent assay (ELISA) kit before, at 1 months after...
This research aimed to excavate compounds with activity reducing hepatocytes lipid accumulation from Delphinium brunonianum. Four novel diterpenoid alkaloids, brunodelphinine B-E, were isolated D. brunonianum together eleven known alkaloids through a phytochemical investigation. Their structures elucidated by comprehensive spectroscopy methods including HR-ESI-MS, NMR, IR, UV, CD, and single-crystal X-ray diffraction analysis. The inhibitory effects of total 15 on evaluated using 0.5 mM FFA...
Alzheimer's disease is a degenerative affecting the central nervous system for which donepezil usually prescribed. The aim of present study was to examine effects on cognitive functions and expression levels β-amyloid (Aβ) in peripheral blood patients with disease. In total, 76 impairment, who visited Department Neurology Binzhou City Center Hospital from June 2015 September 2016, had memory decline more than three consecutive months underwent mini-mental state examination (MMSE) score...
Delphinium trichophorum Franch (DTF), a species endemic to China, has been widely used for centuries in Tibet as an indigenous medicine treating cough, pneumonia, and pulmonary fibrosis. Hetisine-type C20-diterpenoid alkaloids have reported be characteristic active ingredients. Herein, five ones with relatively high contents D. trichophorum, including 2α,11α,13β-triacetylhetisine (DTF1), trichodelphinine A (DTF2), D (DTF3), 2α-acetyl-11α,13β-dihydroxyhetisine (DTF4), C (DTF5), were...
Objective To observe the effects of donepezil hydrochloride on cognitive function and serum insulin-like growth factor-1 (IGF-1) level in patients with vascular dementia. Methods A total 48 dementia admitted to Binzhou Center Hospital from January 2017 September 2018 were divided into experimental group (donepezil treatment group) control (conventional according random number table method, 24 cases each group. The clinical efficacy, scores including mini-mental state examination...
Plumeriae rubrae flos, the dried flowers of Plumeria rubra cv. acutifolia (PRCA), is one most important materials herbal tea in China. Recently, due to lack effective quality evaluation standards, it has been found that (PR) and var. alba (PRVA) were pretended be PRCA material markets.To establish an method for comprehensive assessment on plumeriae distinguishing from its common adulterants, PR PRVA.In this study, a combined application ultrahigh-performance liquid chromatography-quadrupole...
Thiopurine methyltransferase(TPMT)is a key enzyme involved in the metabolism of azathioprine(AZA).There is close association between TPMT polymorphism and AZA-related adverse drug reactions.To fully recognize role AZA as well relationship reactions, to assess activity genotypes prior prescribing, may offer basis for individualized safe medication. Key words: Azathioprine; 6-Mercaptopurine; Adverse reaction