A5100785863- Pharmacological Effects of Natural Compounds
- RNA modifications and cancer
- Photosynthetic Processes and Mechanisms
- Acute Ischemic Stroke Management
- Ginseng Biological Effects and Applications
- Cancer-related molecular mechanisms research
- Drug Transport and Resistance Mechanisms
- Cancer Treatment and Pharmacology
- Peptidase Inhibition and Analysis
- Drug-Induced Hepatotoxicity and Protection
- Inflammatory Biomarkers in Disease Prognosis
- Plant-based Medicinal Research
- Cancer Mechanisms and Therapy
- Pancreatic and Hepatic Oncology Research
- Cancer-related gene regulation
- Venous Thromboembolism Diagnosis and Management
- Plant Molecular Biology Research
- Andrographolide Research and Applications
- Cancer Risks and Factors
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer-related Molecular Pathways
- Traditional Chinese Medicine Studies
- Plant Gene Expression Analysis
- HER2/EGFR in Cancer Research
- Liver Disease Diagnosis and Treatment
Guangzhou University of Chinese Medicine
2018-2025
Hunan Agricultural University
2024-2025
Hebei Medical University
2017-2025
Fourth Hospital of Hebei Medical University
2017-2025
Third Affiliated Hospital of Harbin Medical University
2020-2025
Shandong University
2025
Hebei University of Science and Technology
2025
Harbin Medical University
2016-2025
Harbin Institute of Technology
2025
Heilongjiang Institute of Technology
2025
The protective effects of remote ischemic conditioning (RIC) on acute stroke have been reported. However, the mechanisms RIC not fully elucidated. This study aimed to investigate whether could reduce oxidative stress and inflammatory responses in middle cerebral artery occlusion (MCAO)-reperfusion mice via nuclear factor-E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway. C57BL/6 were subjected MCAO underwent twice daily at 1, 3, 7 days after MCAO. ML385 was used specifically inhibit...
Ferroptosis is a type of adaptive cell death driven by cellular metabolism and iron-dependent lipid peroxidation. Though multiple genes (including SLC7A11 GPX4) have been demonstrated to play key roles in ferroptosis, little known about the epigenetic regulation this process. Here, we report that KDM3B, histone H3 lysine 9 demethylase, can protect against ferroptosis induced Erastin, an inhibitor SLC7A11. KDM3B overexpression HT-1080 cells results decreased methylation. Furthermore,...
Straw incorporation can improve soil fertility and structure. While numerous studies have explored the immediate impacts of straw return on properties crop production, legacy effects long-term remain less understood. In this study, returning a continuous 15 years （SS） non-straw （NS） were collected from Dahe Experimental Station Hebei Academy Agriculture Forestry Sciences in China. The simulation experiments subsequent carried out pots by adding to two types （SS NS）, which degradation rate...
Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible interstitial disease with poor prognosis. The extract of Nervilia fordii (NFE) has shown remarkable benefit in the treatment acute lung injury, cancer, severe respiratory syndrome (SARS). However, potential mechanism efficacy NFE IPF remain unknown. In this study, systematic network pharmacology analysis was used to predict IPF, based on major components elucidated by UPLC-TOF-MS/MS. molecular interactions between...
Abstract The activity of CVT-E002, an aqueous extract containing mainly oligosaccharides and polysaccharides from North American ginseng (Panax quinquefolium), as immunobooster on murine spleen cells peritoneal macrophages, was studied in-vitro. CVT-E002 stimulated the proliferation normal mouse cells, which major responding subpopulation identified B lymphocytes. also activated exudate macrophages leading to enhanced interleukin-1 (IL-1), interleukin-6 (IL-6), tumour necrosis factor-α...
Drug resistance of paclitaxel (TAX), the first-line chemotherapy drug for breast cancer, was reported to develop in 90% patients with especially metastatic cancer. Investigating mechanism TAX cancer cells and developing strategy improving its therapeutic efficiency are crucial cure. We here report an elegant nanoparticle (NP)-based technique that realizes efficient treatment TAX. Using lentiviral vector-mediated gene knockdown, we first demonstrated closely correlated metadherin (MTDH)...
Background The changes in the platelet-to-lymphocyte ratio (PLR) before and after recombinant tissue plasminogen activator (rtPA) treatment time point at which PLR is a potentially valuable prognostic predictor patients wit ischemic stroke remain largely unknown. Therefore, purpose of this study was to explore characteristics evaluate their effects on clinical outcomes 24 h rtPA treatment. Methods This included 741 consecutive with acute who underwent intravenous thrombolysis rtPA. We...
Thyroid cancer is one of the most common endocrine malignancies worldwide, and papillary thyroid (PTC) pathologic type cancer. SQSTM1/p62 activity mediates different biological functions. This study aimed to investigate effect SQSTM1/p62, a multifunctional receptor, on function autophagy characteristics in human PTC cell line TPC-1.A total 105 primary samples matched adjacent normal tissue were obtained evaluate expression p62 clinical patients. A similar pattern was found lines follicular...
The correlation of bile acid (BA) metabolism disorder with the pathogenesis ulcerative colitis (UC) is realized nowadays. Farnesoid X receptor (FXR), a controller for BA homeostasis and inflammation, promising target UC therapy. Nigakinone has potential therapeutic effects on colitis. Herein, we investigated anti-UC mechanism nigakinone in colitic animals induced by dextran sulfate sodium (DSS). related targets involved nucleotide-binding oligomerization domain, leucine-rich repeat, pyrin...
Commercial Saccharomyces cerevisiae plays an important role in the traditional winemaking industry. In this study, correlation of microbial community and aroma compound process alcohol fermentation Cabernet Sauvignon by four different commercial starters was investigated. The results showed that there no significant difference parameters starters, but were differences diversity among starters. wine samples fermented CEC01 had higher abundance. GC-MS detected a total 58 aromatic compounds...