A5051963867- Renal Diseases and Glomerulopathies
- Renal and related cancers
- Genetic and Kidney Cyst Diseases
- Renal cell carcinoma treatment
- Biomedical Research and Pathophysiology
- Venous Thromboembolism Diagnosis and Management
- Chronic Kidney Disease and Diabetes
- Sex work and related issues
- Social Issues and Sustainability
- Migration, Education, Indigenous Social Dynamics
- Social Sciences and Policies
- Birth, Development, and Health
- Immune Cell Function and Interaction
- Cell Adhesion Molecules Research
- Parathyroid Disorders and Treatments
- Magnesium in Health and Disease
- Cancer Treatment and Pharmacology
- Vascular Tumors and Angiosarcomas
- Tuberous Sclerosis Complex Research
- Gender, Violence, Rights in Latin America
- Genomics and Rare Diseases
- Gender, Feminism, and Media
- Spine and Intervertebral Disc Pathology
- Systemic Lupus Erythematosus Research
- Kidney Stones and Urolithiasis Treatments
Hospital Universitario Virgen de la Arrixaca
2013-2024
University of Chile
1999-2022
Hospital Universitario La Paz
2018-2022
INCLIVA Health Research Institute
2019
Hospital Reina Sofía de Murcia
2013-2016
St. Elisabeth Hospital
2010
Bienestar
2008-2009
London Postgraduate Medical and Dental Education
1979
The criteria for the separation of invasive lobular and ductal carcinomas are analysed. Lobular tumours account 14% cancers in our material. widely differing figures given literature mainly attributable to intrinsic difficulties classification. In addition classical dissociated‐cell patterns with single filing, a targetoid appearance related features, variants trabecular, loose alveolar tubular features recognized; ‘solid’ variant requires further investigation. either represent better...
Rationale & ObjectiveAlport syndrome is a common genetic kidney disease accounting for approximately 2% of patients receiving replacement therapy (KRT). It caused by pathogenic variants in the gene COL4A3, COL4A4, or COL4A5. The aim this study was to evaluate clinical and spectrum with autosomal dominant Alport (ADAS).Study DesignRetrospective cohort study.Setting Participants82 families (252 patients) ADAS were studied. Clinical, genetic, laboratory, pathology data collected.ObservationsA...
Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent cause of genetic renal and accounts for 6–10% patients on replacement therapy (RRT). Very few prospective, randomized trials or clinical studies address diagnosis management this relatively disorder. No guidelines are available to date. This a consensus statement presenting recommendations Spanish Working Group Inherited Kidney Diseases, which were agreed following literature search discussions. Levels evidence found C...
Health-related quality of life (HRQoL) patients with X-linked hypophosphatemia (XLH) is lower than that both the general population and other chronic diseases, mainly due to diagnostic delay, treatment difficulties, poor psychosocial support, problems social integration. Early diagnosis optimal are paramount control disease in XLH, avoid complications, maintain or improve their HRQoL. We, therefore, analyzed HRQoL pediatric adult XLH treated conventional therapy Spain.We used several...
ABSTRACT Background Clinical variability among individuals with heterozygous pathogenic/likely pathogenic (P/LP) variants in the COL4A3/COL4A4 genes (also called autosomal dominant Alport syndrome or COL4A3/COL4A4-related disorder) is huge; many are asymptomatic show microhematuria, while others may develop proteinuria and chronic kidney disease (CKD). The prevalence of simple cysts (KC) general population varies according to age, patients advanced CKD prone have them. A possible association...
Abstract Background Some 7-10% of patients on replacement renal therapy (RRT) are receiving it because autosomal dominant polycystic kidney disease (ADPKD). The age at initiation RRT is expected to increase over time. Methods Clinical data 1,586 (7.9%) with ADPKD and 18,447 (92.1%) other nephropathies were analysed from 1984 through 2009 (1984–1991, 1992–1999 2000–2009). Results remained stable the three periods in group (56.7 ± 10.9 (mean SD) vs 57.5 12.1 57.8 13.3 years), whereas increased...
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the activation of autoreactive T and B cells, autoantibody production, immune complex deposition in various organs. Previous evidence showed abnormal accumulation cells thymus lupus-prone mice, but role this population progression remains mostly undefined. Here we analyzed spatial distribution, function, properties thymic cell BWF1 murine model SLE. We found that diseased animals, proliferate cluster structures...
La poliquistosis renal autosómica dominante (PQRAD) es la causa más frecuente de nefropatía genética y representa entre el 6 10% los pacientes en terapia reemplazo (TRR). Muy pocos ensayos prospectivos, aleatorizados o estudios clínicos abordan diagnóstico tratamiento este trastorno relativamente frecuente. No hay guías clínicas disponibles hasta fecha. Este un documento consenso revisada versión anterior del 2014, que presenta las recomendaciones Grupo Trabajo Español Enfermedades Renales...
The clinical manifestations of autosomal dominant polycystic kidney disease (ADPKD) usually appear in adulthood, however pediatric series report a high morbidity. objective the study was to analyze characteristics ADPKD young adults.Family history, hypertension, albuminuria, estimated glomerular filtration rate (eGFR) and imaging tests were examined 346 adults (18-30 years old) out 2521 patients Spanish registry (REPQRAD). A literature review searched for reports on hypertension with more...
OBJECTIVE: To examine the likelihood of Latino day laborers being solicited for sex by other men. MATERIAL AND METHODS: 450 were recruited in Los Angeles, California, from July to September 2005. Logistic regression analysis was used determine which more likely be and subsequently have sex. RESULTS: Thirty-eight percent reported another man while seeking work. Those live longer US, educated screen positive drug dependence. Of those solicited, 9.4% had with their solicitors. screening...
This article reports the characteristics of Latino day laborers who have sex with female commercial workers (CSWs). A sample 450 in Los Angeles was used. Multivariate logistic regression used to determine association independent variables likelihood having a CSW. Overall, 26% reported had CSW previous 12 months. lower found for those more than 6 years education and were married living their spouses. higher met criteria harmful drinking or drug dependence. Commercial work has been associated...
Hereditary kidney diseases (HKD) are a frequent cause of chronic disease, and their diagnosis has increased since the introduction next generation sequencing (NGS). In 2018, Multidisciplinary Unit for Kidney Diseases Region Murcia (UMERH-RM) was founded based on genetic study HKD. The objective this is to analyze results obtained in first 3 years operation, clinical factors associated final diagnosis. All patients studied with HKD gene panel were included. characteristics between those who...
Tuberous sclerosis complex (TSC) is a rare, hereditary, multisystemic disease with broad phenotypic spectrum. Its management requires the collaboration of multiple specialists. Just as in paediatric age, neurologist takes on special importance; adulthood, renal involvement cause greatest morbidity and mortality. There are several recommendations general patients TSC but none that focuses involvement. These respond to need provide guidelines facilitate better knowledge diagnostic-therapeutic...
Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent cause of genetic renal and accounts for 6–10% patients on replacement therapy (KRT). Very few prospective, randomized trials or clinical studies address diagnosis management this relatively disorder. No guidelines are available to date. This a revised consensus statement from previous 2014 version, presenting recommendations Spanish Working Group Inherited Kidney Diseases, which were agreed following literature search...
El complejo esclerosis tuberosa (CET) es una enfermedad rara, hereditaria, multisistémica y con un amplio espectro fenotípico. Su manejo requiere de la colaboración múltiples especialistas. Así como en edad pediátrica cobra especial relieve el neurólogo pediatra, adulta afectación renal causante mayor morbimortalidad. Existen diversas recomendaciones sobre general del paciente CET, pero ninguna que se centre renal. Las presentes responden a necesidad proporcionar pautas para facilitar mejor...
Abstract Background The limited knowledge about the PTEN hamartoma tumor syndrome (PHTS) makes its diagnosis a challenging task. We aimed to define clinical and genetic characteristics of this in Spanish population identify new genes potentially associated with disease. Results reviewed data collected through specific questionnaire series 145 patients phenotypic features compatible PHTS performed molecular characterization several approaches including next generation sequencing whole exome...
Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited nephropathy. Initially, it characterised by growth of renal cysts. Later, progressive deterioration function determines prognosis ADPKD, depending on main factors progression (genetic, volume, and hypertension). Ultrasonography diagnostic technique choice in screening for relatives ADPKD patients. Due to absence specific treatment necessary, many cases, start with replacement therapy. can also be associated...
Kimura’s disease is characterized by benign subcutaneous masses located in the head and neck region, often accompanied regional lymphadenopathy salivary gland involvement. It a rare that predominantly occurs young Asian males. Histological analysis shows follicular hyperplasia with eosinophilic infiltration; blood examination usually reveals eosinophilia elevated concentrations of immunoglobulin E (IgE). The aetiology still unclear; autoimmune diseases, chronic infections delayed...
Several studies have demonstrated the contribution of innate immune cells, including macrophages, in promoting systemic lupus erythematosus (SLE). Macrophages, one most abundant cell populations peritoneal cavity, are considered multifunctional cells with phenotypic plasticity. However, functional properties macrophages steady-state and during progression SLE remain poorly defined.Using [NZB × NZW]F1 (BWF1) murine model SLE, we analyzed phenotype function disease's onset. We found a higher...