A5080249172- Anesthesia and Sedative Agents
- Intensive Care Unit Cognitive Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Neurotoxicity Research
- Respiratory Support and Mechanisms
- EEG and Brain-Computer Interfaces
- Airway Management and Intubation Techniques
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Optical Imaging and Spectroscopy Techniques
- Cardiac Arrest and Resuscitation
- Hemodynamic Monitoring and Therapy
- Restraint-Related Deaths
- Transplantation: Methods and Outcomes
- Anesthesia and Pain Management
- Neural dynamics and brain function
- Analytical Methods in Pharmaceuticals
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Epilepsy research and treatment
- Pain Management and Placebo Effect
- Nausea and vomiting management
- Cardiovascular and Diving-Related Complications
- Medical Malpractice and Liability Issues
- Liver Disease Diagnosis and Treatment
- Patient Safety and Medication Errors
Ghent University Hospital
2010-2024
Ghent University
2016
University of Groningen
2014
University Medical Center Groningen
2014
Northwestern University
2012
Williams & Associates
2012
Background The noxious stimulation response index (NSRI) is a novel anesthetic depth ranging between 100 and 0, computed from hypnotic opioid effect-site concentrations using hierarchical interaction model. authors validated the NSRI on previously published data. Methods data encompassed 44 women, American Society of Anesthesiology class I, randomly allocated to three groups receiving remifentanil infusions targeting 2, 4 ng/ml. Propofol was given at stepwise increasing target...
To investigate the safety and efficacy of somatostatin as liver inflow modulator in patients with end-stage disease (ESLD) clinically significant portal hypertension (CSPH) undergoing transplantation (LT) (ClinicalTrials.gov number,01290172).In LT, hyperperfusion can severely impair graft function survival, mainly cases partial LT.Thirty-three LT for ESLD CSPH were randomized double-blindly to receive or placebo (2:1). The study drug was administered intraoperatively 5-mL bolus...
Background Several new measures based on the regularity of electroencephalogram signal for assessment depth anesthesia/sedation have been proposed recently. In this study we analyze influence remifentanil and frequency content performance a set such measures. Methods Forty-five patients with American Society Anesthesiologists physical status I were randomly allocated to one three groups according received dose predicted effect compartment-controlled (0, 2, 4 ng/ml). All 45 stepwise increased...
Background Various pharmacodynamic response surface models have been developed to quantitatively describe the relationship between two or more drug concentrations with their combined clinical effect. We examined interaction of remifentanil and sevoflurane on probability tolerance shake shout, tetanic stimulation, laryngeal mask airway insertion, laryngoscopy in patients compare performance five different models. Methods Forty preoperatively received (0-12 ng/ml) (0.5-3.5 vol.%) according a...
Background The purpose of this study was to evaluate a new, physiologically inspired method for the analysis electroencephalogram during propofol-remifentanil anesthesia. Based on fixed-order autoregressive moving-average modeling, hypothesized be capable dissociating effects that hypnotic and analgesic agents have brain electrical activity. Methods Raw electroencephalographic waves from previously published were reanalyzed. In study, 45 American Society Anesthesiologists status I patients...
The authors studied the interaction between sevoflurane and remifentanil on bispectral index (BIS), state entropy (SE), response (RE), Composite Variability Index, Surgical Pleth by using a surface methodology. also influence of stimulation this interaction.Forty patients received combined concentrations (0 to 12 ng/ml) (0.5 3.5 vol%) according crisscross design (160 concentration pairs). During pseudo-steady-state anesthesia, pharmacodynamic measures were obtained before after series...
Abstract Background: The interaction of sevoflurane and opioids can be described by response surface modeling using the hierarchical model. We expanded this for combined administration sevoflurane, opioids, 66 vol.% nitrous oxide (N2O), historical data on motor hemodynamic responsiveness to incision, minimal alveolar concentration, concentration block autonomic reflexes nociceptive stimuli, respectively. Methods: Four potential actions N2O were postulated: (1) is equivalent A ng/ml fentanyl...
performing anesthesia monitoring measure.Significance: These techniques hold potential for and may be generally applicable tracking brain states.
Background: Perioperative respiratory adverse events are among the most common critical incidents in pediatric anesthesia. Three risk prediction models have been developed to predict occurrence of such children. However, these tools were only internally validated, limiting generalization. The Respiratory Adverse Events Pediatric Ambulatory Anesthesia tool by Subramanyam et al. consists five predictors: age ≤ 3 years, ASA physical status II and III, morbid obesity, preexisting pulmonary...
Investigators studied pregnancy-related subarachnoid hemorrhage (SAH) using the Nationwide Inpatient Sample of Healthcare Cost and Utilization Project.Logistic regression identified independent predictors SAH.There were 639 cases (5.8 per 100,000 deliveries) SAH in cohort during study period.More than half occurred postpartum.Advancing age, African-American race, Hispanic ethnicity, hypertensive disorders, coagulopathy, tobacco, drug or alcohol abuse, intracranial venous thrombosis, sickle...