Tramadol, a weak μ-opioid receptor agonist, has been used worldwide for pain management. It is considered to have favorable safety profile without serious adverse events; however, issues of respiratory depression were proposed by regulatory governments. We aimed examine the risk and contributing factors associated with tramadol-related using real-world database, VigiBase. Disproportionality analysis tramadol tramadol/paracetamol was performed proportional reporting ratios, odds information...

Background and Objectives : Arterial stiffness is a precursor to premature cardiovascular disease.The augmentation index (AI) pulse pressure (PP) are risk factors.The aim of this study was define the diagnostic values AI PP from peripheral arterial central aortic waveforms in healthy subjects.Subjects Methods We recruited 522 consecutive subjects (mean age 46.3±9.6 years, 290 males) who came our facility for comprehensive medical testing.We measured body mass (BMI), blood pressure, PP, wave...

We investigated the risk factors for radiographic bone damage to foot joints in patients with chronic gout among various patient characteristics and serum inflammatory cytokines such as interleukin 1ß (IL-1ß), IL-6, soluble IL-6 receptor (sIL-6R), osteoprotegerin (OPG), activator of nuclear factor-κB ligand (RANKL).Fifty consecutive male 54 age-matched healthy controls were enrolled. Serum levels including IL-1ß, sIL-6R, OPG, RANKL measured using ELISA. Radiographic indices erosion scores,...

To develop a novel and effective drug that could enhance cognitive function neuroprotection, we newly synthesized maltolyl p-coumarate by the esterification of maltol p-coumaric acid. In present study, investigated whether improve decline in scopolamine-injected rats amyloid beta peptide(1-42)-infused rats. Maltolyl was found to attenuate deficits both rat models using passive avoidance test reduce apoptotic cell death observed hippocampus We also examined neuroprotective effects vitro...

With increasing demands for medical care by society, the system, and general citizens rapid changes in doctor’s awareness, competencies required of doctors are also changing. The goal this study was to develop a competency framework from patient’s perspective, make it basis development milestones entrustable professional activities each period student education resident training. To end, big data analysis using topic modeling performed on domestic international research papers (2011–2020),...

The notable characteristics of recently emerged Antibody-Drug Conjugates (ADCs) encompass the targeting Human Epidermal growth factor Receptor 2 (HER2) through monoclonal antibodies (mAbs) and a high ratio drug to antibody (DAR). achievements Kadcyla® (T-DM1) Enhertu® (T-Dxd) have demonstrated that HER2-targeting antibodies, such as trastuzumab, shown be competitive in terms efficacy price for development. Furthermore, with arrival T-Dxd Trodelvy®, high-DAR (7-8) ADCs, which differ from...

In 2020, during the coronavirus disease (COVID-19) pandemic, medical students were placed in a learning environment that exposed them to unsafe clinical settings. this study, using phenomenological approach, we analyze experiences of fourth-year Daegu area South Korea, region experienced high concentration COVID-19 infections.The essays 80 from four schools who agreed participate study utilized final data analysis. The analyzed proposed analysis.Forty-seven condensed meaning units, twelve...

To develop a new method for gastric cancer detection with juice using melanoma-associated gene (MAGE) RNA and pepsinogen (PG).In total, 183 paired serum specimens were obtained from 134 patients 49 healthy individuals. The analyzed MAGE A1 to A6 nested reverse transcription-polymerase chain reaction. PG measured I II immunoassay.The I/II ratios more accurate than those of serum. combination test the ratio was most accurate, sensitivity 77.6% specificity 87.8%. 78.8% stage not influenced by...

Several studies have shown an association between low hand grip strength (HGS) and functional limitations. This study aims to elucidate the HGS We used nationwide health examination data included 13,517 Korean adults that were aged ≥ 50 years. measured using digital dynamometer maximum value of dominant was divided into quartiles for analysis. Functional limitations assessed by self-administered questionnaires. categorized 24 reported causes musculoskeletal, cardiometabolic,...

서 론 비만은 다양한 심혈관계 합병증과 밀접하게 관련된 만성 대사성 장애이다. 1 지방간, 골관절염, 통풍, 수면무호흡증, 폐성심, 무 월경, 불임증, 우울증 등 신체 전반의 질병과 관련이 있고 동맥 경화, 고지혈증, 고혈압, 당뇨병, 협심증, 심근경색, 뇌졸중 질환의 이환율과 사망률에 큰 영향을 끼친다

The purpose of this study was to explore, using topic modeling, the social value doctors and medicine demanded by society as reflected in published newspaper articles Korea. Ultimately, aimed reflect needs process developing Patient-Centered Doctor’s Competency Framework For purpose, a total 2,068 from 2016 2020 were analyzed. Through modeling these over past 5 years, 18 topics derived divided into four categories. Focusing on keywords, specific years proportion year results make it possible...

Dietary Na+ or Na+/K+ ratio has been reported to be associated with bone mineral density (BMD). However, this remains unclear, and only a few studies have on the Korean population. Therefore, study aimed determine association between dietary Na+, K+, ratios BMD in middle-aged women.This used data from Korea National Health Nutrition Examination Survey 2008-2011. A total of 3,690 women aged >50 years were included. Study participants classified into quartiles (lowest quartile Q1-highest Q4)...

We evaluated the effects of socioeconomic factors and psychosocial factors, both individually combined, on all-cause mortality risk (mortality risk).We conducted an 8-year (2006-2014) longitudinal analysis 10,247 individuals who took part in Korean Longitudinal Study Aging, a nationwide survey people aged 45-79 years. Socioeconomic vulnerability (SEV) was assessed with such as education, household income, commercial health insurance, residential area. Mental (MH) depression, social...

During the Coronavirus Infection Disease-19 (COVID-19) pandemic, number of patients released from quarantine is exceeding newly diagnosed cases. This study a retrospective cohort in which consultation data were collected COVID-19 follow-up health program. The studied population was selected who recovered after and treatment for Daegu City Gyeongsangbukdo province, Korea, March to June 2020. healthcare providers comprised 20 family-medicine specialists consulted educated through phone calls...

Purpose Today's students have distinctive generational characteristics and increased psychopathology tension. The authors investigated the negative experiences of Late Millennial in medical school to draw implications for student support. Methods explored students' using critical incident technique. conducted semi-structured in-depth interviews with 13 students, between February May 2016. focused on occurrences that significantly influenced lives negatively from perspective. All were...

The coronavirus pandemic has increased reliance on the internet as a tool for disseminating information; however, information is useful only when it can be understood. Prior research shown that web-based health not always easy to understand. It yet known whether Korean-language COVID-19 from general public understand.We aimed evaluate readability of intended national portal South Korea.A total 122 publicly available documents written in Korean were obtained portal. We determined level (at or...