A5071651455- Dendrimers and Hyperbranched Polymers
- Polyoxometalates: Synthesis and Applications
- Liquid Crystal Research Advancements
- Chemical Synthesis and Reactions
- Chemical Synthesis and Analysis
- Supramolecular Self-Assembly in Materials
- biodegradable polymer synthesis and properties
- Nanoparticle-Based Drug Delivery
- Innovative Microfluidic and Catalytic Techniques Innovation
- Advanced Drug Delivery Systems
- Synthesis and Properties of Aromatic Compounds
- Synthesis and properties of polymers
- Advanced Polymer Synthesis and Characterization
- Advanced biosensing and bioanalysis techniques
- Synthetic Organic Chemistry Methods
- Asymmetric Hydrogenation and Catalysis
- 3D Printing in Biomedical Research
- Antimicrobial agents and applications
- Metal-Organic Frameworks: Synthesis and Applications
- Asymmetric Synthesis and Catalysis
- RNA Interference and Gene Delivery
- Advanced Nanomaterials in Catalysis
- Graphene and Nanomaterials Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Cancer Research and Treatment
Universidad de Zaragoza
2015-2025
Instituto de Nanociencia y Materiales de Aragón
2020-2025
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
2017-2025
Instituto de Salud Carlos III
2020-2025
Consejo Superior de Investigaciones Científicas
2007-2022
Institut Català d'Investigació Química
2009-2013
Eindhoven University of Technology
2007-2012
Universidad Autónoma de Madrid
2009
KU Leuven
2009
Institute of Macromolecular Chemistry
2009
Molecular organization: Chiral benzene tricarboxamides with methyl substituents at defined positions self-assemble into supramolecular polymers of preferred helicity by three-fold alpha-helical-type hydrogen bonding. The odd-even effect is operative and all derivatives are liquid crystalline showing a Col(ho) phase (see figure).Asymmetric benzene-1,3,5-tricarboxamides (aBTAs) comprising two n-octyl one chiral methyl-alkyl side chain were synthesised characterised. influence the position...
Abstract N‐Centred benzene‐1,3,5‐tricarboxamides (N‐BTAs) composed of chiral and achiral alkyl substituents were synthesised their solid‐state behaviour self‐assembly in dilute alkane solutions investigated. A combination differential scanning calorimetry (DSC), polarisation optical microscopy (POM) X‐ray diffraction revealed that the N‐BTA derivatives with branched 3,7‐dimethyloctanoyl chains liquid crystalline mesophase was assigned as Col ho . In contrast, linear tetradecanoyl or octanoyl...
Several oligo(p-phenylene-vinylene) oligomers capped with a guanosine or guanine moiety have been prepared via palladium-catalyzed cross-coupling reaction. Their self-assembly, in both the absence and presence of alkaline salts, has studied by means different techniques solution (NMR, MS, UV−vis, CD, fluorescence), solid state (X-ray diffraction), on surfaces (STM, AFM). When no salt is added, these π-conjugated molecules self-associate mixture hydrogen-bonded oligomers, among which...
Abstract The appearance and rapid spread of drug resistant strains tuberculosis (TB), one the deadliest infectious diseases, pose a serious threat to public health increase need for shorter, less toxic, more effective therapies. Developing new drugs is difficult often associated with side effects, so nanotechnology has emerged as tool improve current treatments rescue having elevated toxicity or poor solubility. Due their size surface chemistry, antimicrobial‐loaded nanocarriers are avidly...
The mechanical microenvironment plays a crucial role in the evolution of colorectal cancer, complex disease characterized by heterogeneous tumors with varying elasticity. Toward setting up distinct scenarios, herein, we describe preparation and characterization gelatin methacrylamide (GelMA)-based hydrogels via two different mechanisms: free-radical photopolymerization photo-induced thiol-ene reaction. A precise stiffness modulation covalently crosslinked scaffolds was achieved through...
The synthesis and characterization of two families ionic liquid crystal dendrimers consisting the ammonium salts commercially available poly(amidoamine) (G = 0-5) poly(propylene imine) 1-5) three long-chain carboxylic acids are reported. crystalline behavior was investigated by means differential scanning calorimetry, polarizing light optical microscopy, X-ray diffractometry. thermal stability materials further studied NMR. Most show lamellar mesomorphism, them exhibit columnar mesomorphism....
A polystyrene-supported, pyrrolidine-based catalyst depicting very high activity and excellent stereoselectivity in the anti-Mannich reaction of aldehydes ketones has been developed. The robust, immobilized successfully used implementation a continuous flow process with short residence times (down to 6 min) for production highly enantioenriched anti-type Mannich adducts at preparative scale.
Developing artificial metalloenzymes that possess a superior performance to their natural counterparts is an attractive concept. Polyoxometalates (POMs) are class of anionic molecular metal-oxides with excellent redox properties and bioactivity. We have recently introduced "POMlymers" - covalently conjugated POM-peptide hybrid materials where the polypeptide chain obtained through ring-opening polymerisation (ROP) α-amino acid N-carboxyanhydrides (NCA) on inorganic POM scaffold. Attracted by...
The synthesis and characterization of a new family ionic liquid crystal dendrimers consisting the ammonium salts commercially available poly(propylene imine) (G = 1−5) 4-decyloxy-, 3,4-didecyloxy-, 3,4,5-tridecyloxybenzoic acids are reported. crystalline behavior was investigated by means differential scanning calorimetry, polarizing-light optical microscopy, X-ray diffractometry. Dendrimers with mono- didecyloxybenzoate moieties show lamellar mesomorphism, namely, smectic A, whereas those...
Substituted benzene-1,3,5-tricarboxamides (BTAs) 1–4 comprising polar tetraethyleneglycol (tetraEG) and/or apolar (R)-3,7-dimethyloctyl side chains were synthesised and their self-assembly in the solid state solution was investigated. While BTA 1 (comprising 3 chains) shows helical columnar packing via threefold α-helical type intermolecular hydrogen bonding up to high dilutions alkane (10−5 M), order is only preserved for asymmetric 2 a concentrated (10−2 M). The association constant Kass...
The application of polystyrene-immobilized proline-based catalysts in packed-bed reactors for the continuous-flow, direct, enantioselective α-aminoxylation aldehydes is described. system allows easy preparation a series β-aminoxy alcohols (after reductive workup) with excellent optical purity and an effective catalyst loading ca. 2.5% (four-fold reduction compared to batch process) working at residence times ca . 5 min.
The increasing resistance of pathogenic microorganisms against common treatments requires innovative concepts to prevent infection and avoid long-term microbe viability on commonly used surfaces. Here, we report the preparation a hybrid antimicrobial material based combination microbiocidal polyoxometalate-ionic liquids (POM-ILs) biocompatible polymeric support, which enables development surface coatings that microbial adhesion. composite is an antibacterial antifungal room-temperature...
An in depth investigation of the fine structure adopted by helical stacks C3-discotics 1 incorporating three 3,3′-diamino-2,2′-bipyridine units is described. In bulk molecules display liquid crystalline behaviour a temperature window >300 K and an ordered rectangular columnar mesophase (Colro) with inter-disc distance 3.4 Å assigned. X-Ray diffraction on aligned samples has also revealed superstructure state, rotation angle 13–16° between consecutive discs. The proposed phase been further...
Lighten the load! A family of enantiopure 4-oxy-substituted 3-aminopyrrolidines arising from enantioselective ring-opening meso-3-pyrroline oxide have been developed as catalysts for asymmetric, anti-selective Mannich reaction (see scheme; PMP=p-methoxyphenyl; PG=protecting group). Very high catalytic activity (down to 0.01 mol % loading) and stereoselectivity recorded. Detailed facts importance specialist readers are published "Supporting Information". Such documents peer-reviewed, but not...
Exposure of nanomaterials (NMs) to biological medium results in their direct interaction with biomolecules and the formation a dynamic biomolecular layer known as corona. Despite numerous published data on nano-biointeractions, role protein glycosylation formation, characteristics, fate such nano-biocomplexes has been almost completely neglected, although most serum proteins are glycosylated. This study aimed systematically investigate differences metallic NPs glycosylated vs nonglycosylated...
Abstract C 3 ‐symmetrical molecules are described which consists of a 1,3,5‐benzenetricarboxamide core extended with dipeptide fragments bearing peripheral mesogenic groups. Small structural modifications in the fragment have been performed to demonstrate their influence on stability stacks and order within self‐assemblies formed. Seven discs investigated, all different combinations glycine, L ‐ and/or D ‐phenylalanine fragments. Characterization these discotics neat state using differential...
The ring-opening polymerisation of α-amino acid N-carboxyanhydrides (NCAs) offers a simple and scalable route to polypeptides with predicted narrow molecular weight distributions. Here we show how polyoxometalates (POMs)-redox-active metal-oxide anions-can serve as inorganic scaffold initiators for such NCA polymerisations. This "On-POM polymerisation" strategy serves an innovative platform design hybrid materials additive or synergistic properties stemming from the polypeptide component...
Biomimetic 3D models emerged some decades ago to address 2D cell culture limitations in the field of replicating biological phenomena, structures or functions found nature. The fabrication hydrogels for cancer disease research enables study processes including growth, proliferation and migration their design is based on encapsulation tumoral cells within a tunable matrix. In this work, platform gelatin methacrylamide (GelMA)-based photocrosslinked scaffolds with embedded colorectal (HCT-116)...
Intranasal drug delivery to the brain offers a promising strategy overcome biological barriers. Chitosan-coated nanoemulsion-based nanocapsules demonstrate significant potential due their mucoadhesive properties, ability permeate epithelial cells, and solubilize poorly water-soluble drugs, making them ideal candidates for bypassing blood-brain barrier overcoming nasal mucosa. To ensure effective delivery, it is critical assess integrity of these during transit across such In this study, we...
Corrosion of metals and other materials in marine environments poses significant economic, operational, safety, environmental challenges across the oil gas industry, renewable energy sector, maritime infrastructure.