A5034989464- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Advancements in Transdermal Drug Delivery
- Spectroscopy Techniques in Biomedical and Chemical Research
- Neuroscience and Neural Engineering
- Stroke Rehabilitation and Recovery
- EEG and Brain-Computer Interfaces
- Botulinum Toxin and Related Neurological Disorders
- Extracellular vesicles in disease
- Digital Imaging for Blood Diseases
- Electrochemical Analysis and Applications
- MicroRNA in disease regulation
- Radiation Therapy and Dosimetry
- Cerebral Palsy and Movement Disorders
- Advanced Biosensing Techniques and Applications
- RNA Interference and Gene Delivery
- Context-Aware Activity Recognition Systems
- Nanoparticles: synthesis and applications
- Advanced Drug Delivery Systems
- Neural dynamics and brain function
- Electrochemical sensors and biosensors
- Lipid Membrane Structure and Behavior
- Boron Compounds in Chemistry
- Curcumin's Biomedical Applications
Don Carlo Gnocchi Foundation
2012-2024
International Flame Research Foundation
2015
Mylan (Switzerland)
2014-2015
University of Milano-Bicocca
2011
Fondazione per Adroterapia Oncologica
1995
Istituto Nazionale di Fisica Nucleare, Sezione di Milano
1989
The use of exosomes for diagnostic and disease monitoring purposes is becoming particularly appealing in biomedical research because the possibility to study directly biological fluids some features related organs from which originate. A paradigmatic example are brain-derived that can be found plasma used as a direct read-out status central nervous system (CNS). Inspired by recent remarkable development plasmonic biosensors, we have designed surface plasmon resonance imaging (SPRi) assay...
Abstract Extracellular vesicles (EVs) from mesenchymal stromal cells (MSC) are emerging as valuable therapeutic agents for tissue regeneration and immunomodulation, but their clinical applications have so far been limited by the technical restraints of current isolation characterisation procedures. This study shows first time successful application Raman spectroscopy label-free, sensitive reproducible means carrying out routine bulk MSC-derived before use in vitro or vivo , thus promoting...
Abstract Background The majority of stroke survivors experiences significant hand impairments, as weakness and spasticity, with a severe impact on the activity daily living. To objectively evaluate deficits, quantitative measures are needed. aim this study is to assess reliability, validity discriminant ability instrumental provided by robotic device for rehabilitation, in sample patients subacute stroke. Material methods In study, 120 40 controls were enrolled. Clinical evaluation included...
Aims: Chronic lung allograft dysfunction represents the main cause of death after transplantation, and so far there is no effective therapy. Mesenchymal cells (MCs) are primarily responsible for fibrous obliteration small airways typical chronic dysfunction. Here, we engineered gold nanoparticles containing a drug in hydrophobic section to inhibit MCs, exposing on outer hydrophilic surface monoclonal antibody targeting MC-specific marker (half-chain with everolimus). Materials & methods:...
Heamatopoietic cancer cells from patients were objectively and accurately recognized by high-resolution Raman imaging their characteristic spectra.
Among polymeric nanoparticles designed for cancer therapy, PLGA have become one of the most popular devices chemotherapeutic-based nanoformulations against several kinds malignant diseases. Promising properties, including long-circulation time, enhanced tumor localization, interference with "multidrug" resistance effects, and environmental biodegradability, often result in an improvement drug bioavailability effectiveness. In present work, we synthesized...
Robot-mediated therapy is a viable approach for upper limb rehabilitation. The highly complex segment and the identification of appropriate devices capable rehabilitating it globally (from shoulder to hand) in clinical practice crucial. In this work, we aimed: (i) describe an used identifying set technological robotic treat limb, (ii) evaluate feasibility identified practice. Using ad-hoc form, multidisciplinary team four sensor-based limb. Then, 30 stroke patients were enrolled assigned two...
We present a new 3D surface-enhanced Raman spectroscopy substrate made of branched gold nanoparticles supported on ZnO tetrapods that was proved to be effective in different biomedical application such as drug detection and cancer cells analysis.
In order to minimize the impact of systemic toxicity drugs in treatment local acute and chronic inflammatory reactions, achievement reliable efficient delivery therapeutics in/through skin is highly recommended. While use nanoparticles now an established practice for drug intravenous targeted delivery, their transdermal penetration still poorly understood this important administration route remains almost unexplored. present study, we have synthesized magnetic (iron oxide) (MNP) coated with...
In our study, 2D nanopillar arrays with plasmonic crystal properties are optimized for surface-enhanced Raman spectroscopy (SERS) application and tested in a biochemical assay the simultaneous detection of multiple genetic leukemia biomarkers. The special fabrication process combining soft lithography plasma deposition techniques allows tailoring structural chemical parameters surfaces. this way, it has been possible to tune resonance spectral position close excitation wavelength...
A brain-computer interface (BCI) directly uses brain-activity signals to allow users operate the environment without any muscular activation. Thanks this feature, BCI systems can be employed not only as assistive devices, but also neurorehabilitation tools in clinical settings. However, several critical issues need addressed before using neurorehabilitation, ranging from signal acquisition and selection of proper paradigm evaluation affective state, cognitive load system acceptability users....