A5049229865- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Protein purification and stability
- 3D Printing in Biomedical Research
- Gastrointestinal motility and disorders
- Additive Manufacturing and 3D Printing Technologies
- Pharmaceutical studies and practices
- Injection Molding Process and Properties
- Hydrogels: synthesis, properties, applications
- Advancements in Transdermal Drug Delivery
- biodegradable polymer synthesis and properties
- Granular flow and fluidized beds
- Innovative Microfluidic and Catalytic Techniques Innovation
- Microencapsulation and Drying Processes
- Polysaccharides Composition and Applications
- Dysphagia Assessment and Management
- Drug-Induced Hepatotoxicity and Protection
- Nanoparticle-Based Drug Delivery
- Field-Flow Fractionation Techniques
- Inhalation and Respiratory Drug Delivery
- Powder Metallurgy Techniques and Materials
- Food composition and properties
- Crystallization and Solubility Studies
- Textile materials and evaluations
- Biosimilars and Bioanalytical Methods
University of Milan
2014-2024
Massachusetts College of Pharmacy and Health Sciences
2009-2010
Boston University
2010
The pulsatile-release Chronotopic™ system was conceived of as a drug-containing core surrounded by coat made swellable/soluble hydrophilic polymers, the latter being able to provide programmable lag phase prior drug liberation. This also proposed in colon-targeting configuration, entailing gastroresistant film prevent early interaction inner with gastric fluids and enabling attainment matching small intestinal transit time. Over years, various multiple-step manufacturing processes have been...
The use of co-processed materials for Orally Disintegrating Tablets (ODT) preparation by direct compression is well consolidated. However, the evaluation their potential ODT 3D printing technology remains almost unexplored. present study aimed to estimate commercially available excipients, conventionally applied in protocols, ODTs with binder jetting-3D technology. latter was selected among techniques because deposition multiple powder layers allows obtaining highly porous and easily...
One of the goals pharmaceutical sciences is amelioration targeted drug delivery. In this context, nanocarrier-dependent transportation represents an ideal method for confronting a broad range human disorders. study, we investigated possibility improving selective release anti-cancer paclitaxel (PTX) in gastro-intestinal tract by encapsulating it into biodegradable nanoparticles made FDA-approved poly(lactic-co-glycolic acid) (PLGA) and coated with polyethylene glycol to improve their...
Oral colon delivery systems based on a dual targeting strategy, harnessing time- and microbiota-dependent release mechanisms, were designed in the form of drug-containing core, swellable/biodegradable polysaccharide inner layer gastroresistant outer film. High-methoxyl pectin was employed as functional coating polymer applied by spray-coating or powder-layering. Stratification powder required use low-viscosity hydroxypropyl methylcellulose water solution binder. These coatings exhibited...
In order to minimize the impact of systemic toxicity drugs in treatment local acute and chronic inflammatory reactions, achievement reliable efficient delivery therapeutics in/through skin is highly recommended. While use nanoparticles now an established practice for drug intravenous targeted delivery, their transdermal penetration still poorly understood this important administration route remains almost unexplored. present study, we have synthesized magnetic (iron oxide) (MNP) coated with...