A5102982584- Sinusitis and nasal conditions
- Asthma and respiratory diseases
- Cardiac Imaging and Diagnostics
- Nasal Surgery and Airway Studies
- Head and Neck Surgical Oncology
- Allergic Rhinitis and Sensitization
- Coronary Interventions and Diagnostics
- Olfactory and Sensory Function Studies
- Infectious Diseases and Mycology
- Advanced X-ray and CT Imaging
- Advanced MRI Techniques and Applications
- Cystic Fibrosis Research Advances
- Advanced Chemical Sensor Technologies
- Lipoproteins and Cardiovascular Health
- Protist diversity and phylogeny
- Biochemical Analysis and Sensing Techniques
- Atomic and Subatomic Physics Research
- Venous Thromboembolism Diagnosis and Management
- Radiomics and Machine Learning in Medical Imaging
- Aortic Thrombus and Embolism
- Cancer, Lipids, and Metabolism
- Ultrasound in Clinical Applications
- Nitric Oxide and Endothelin Effects
- Radiation Dose and Imaging
- Infective Endocarditis Diagnosis and Management
China Medical University
2025
Beijing Tongren Hospital
2013-2024
Capital Medical University
2015-2024
Beijing Anzhen Hospital
2014-2024
Beijing Municipal Education Commission
2023-2024
Beijing Institute of Neurosurgery
2013-2023
Capital University
2014
Industrial Research Institute of Ishikawa
2014
NGM Biopharmaceuticals (United States)
2012
Ministry of Education of the People's Republic of China
2011
Chronic rhinosinusitis with nasal polyps (CRSwNP), a mainly Th2 cytokine-mediated disease, often involves mucus secretion. Recent evidence suggests that transmembrane protein 16A (TMEM16A), calcium-activated Cl- channel (CaCC), can regulate secretion from airway epithelium by transepithelial electrolyte transport and hydration. However, the role of TMEM16A in mucin production/secretion is not clear. This study was conducted to determine mediating human polyp epithelial cells (HNPECs) induced...
Gastrointestinal bypass surgeries that result in rerouting and subsequent exclusion of nutrients from the duodenum appear to rapidly alleviate hyperglycemia hyperinsulinemia independent weight loss. While mechanism(s) responsible for normalization glucose homeostasis remains be fully elucidated, this rapid coupled with well-known effects vagal inputs into suggests a neurohormonally mediated mechanism. Our results show duodenal surgery on obese, insulin-resistant Zucker fa/fa rats restored...
Background Allergic rhinitis(AR) is an increasing challenge to public health worldwide. Exposure environmental black carbon (BC) associated with increased risk of allergic rhinitis, but the molecular mechanisms underlying its toxicity have not been fully elucidated. The aims present study were therefore determine effect BC on expression interleukin 1β (IL‐1β) and investigate mechanism BC‐induced IL‐1β production in pollen‐sensitized human nasal epithelial cells (hNECs). Methods Nasal mucosal...
Inflammation induced by activated macrophages within vulnerable atherosclerotic plaques (VAPs) constitutes a significant risk factor for plaque rupture. Translocator protein (TSPO) is highly expressed in macrophages. This study investigated the effectiveness of TSPO radiotracers, 18F-FDPA, detecting VAPs and quantifying inflammation rabbits. 18 New Zealand rabbits were divided into 3 groups: sham group A, VAP model B, evolocumab treatment C. 18F-FDPA PET/CTA imaging was performed at 12, 16,...
<b><i>Background:</i></b> The aim of this study was to investigate the effect corticosteroids, antihistamines, and preservatives benzalkonium chloride (BKC) potassium sorbate (PS) in intranasal medications on human nasal epithelial ciliary beat frequency (CBF). <b><i>Methods:</i></b> Primary ciliated cell cultures from mucosa chronic sinusitis patients were established. Changes CBF treated/untreated with or assessed using high-speed digital...
Magnetocardiography (MCG) is a novel non-invasive technique that detects subtle magnetic fields generated by cardiomyocyte electrical activity, offering sensitive detection of myocardial ischemia. This study aimed to assess the ability MCG predict impaired perfusion using single-photon emission computed tomography (SPECT).
Background Nasal irrigation (NI) is commonly used to treat several sinonasal diseases, including chronic rhinosinusitis with nasal polyps (CRSwNP); however, the effects of NI on epithelium are not fully known. The aim this study was investigate solutions epithelial mucociliary and barrier functionality in primary cultured human cells (HNECs). Methods HNECs from control subjects patients CRSwNP were established as air‐liquid interface (ALI) cultures. Differentiated cultures treated different...
Mucus hypersecretion and goblet cell upregulation are common features of chronic rhinosinusitis with nasal polyps (CRSwNP). Although epidermal growth factor (EGF) has been reported to stimulate the expression MUC5AC, major macro-molecular constituent airway mucus, precise mechanisms underlying regulation MUC5AC still not fully understood. The aim this study therefore was investigate role EGF in mucin define involvement transmembrane protein 16A (TMEM16A) mediating EGF-induced mucus...
Abstract Background Studies have independently indicated that eosinophils and histone deacetylases (HDACs) may compromise the integrity of epithelial barrier in nasal polyps; however, underlying mechanisms are not clear. In this study, we aimed to investigate role eosinophilia HDACs regulation tight junctions (TJs) chronic rhinosinusitis with polyps (CRSwNP) patients. Methods Expression mRNAs proteins TJs biopsy specimens air‐liquid interface (ALI) human cell cultures (HNECs) from...
Abstract Background This study was performed to determine whether there any association between abnormal DNA methylation of a thymic stromal lymphopoietin (TSLP) locus and pathogenesis chronic rhinosinusitis (CRS). Methods A total 48 CRS patients with nasal polyps (CRSwNP), 28 without (CRSsNP) 21 control subjects were enrolled into the study; evaluated for serum IgE level, olfactory score resistance. Samples obtained from CRSwNP patients, ethmoid mucosae CRSsNP inferior turbinate (IT) mucosa...
<i>Objectives:</i> Our purpose was to investigate the role of nitric oxide (NO) synthase substrate <i>L</i>-arginine (<i>L</i>-arg) in regulation airway ciliary beat frequency (CBF). <i>Methods:</i> We studied effects <i>L</i>-arg on CBF rabbit tracheal epithelial cells by using high-speed digital microscopy and determined expression distribution neuronal (nNOS), inducible (iNOS) endothelial (eNOS) intact mucosa isolated cilia...
Abstract Age-related decline in olfactory function affects the quality of life elderly people and also potentially represents an early clinical symptom neurodegenerative disorder. Olfactory bulb (OB) plays a central role information transmitting signal processing. The mechanisms underlying this impairment remain unclear. In current study, microarray was used to investigate differentially expressed protein coding genes (PCGs) long non-coding RNAs (lncRNAs) OBs from three groups mice different...