A5027623641- Skin Protection and Aging
- Chemical Synthesis and Analysis
- Asymmetric Synthesis and Catalysis
- Antimicrobial Peptides and Activities
- Synthetic Organic Chemistry Methods
- Cyclopropane Reaction Mechanisms
- Advancements in Transdermal Drug Delivery
- Click Chemistry and Applications
- Olfactory and Sensory Function Studies
- Peptidase Inhibition and Analysis
- Asymmetric Hydrogenation and Catalysis
- Ferrocene Chemistry and Applications
- Organometallic Complex Synthesis and Catalysis
- Protein Hydrolysis and Bioactive Peptides
- Sensory Analysis and Statistical Methods
- Biochemical Analysis and Sensing Techniques
- Mast cells and histamine
- Science Education and Perceptions
- Signaling Pathways in Disease
- Silk-based biomaterials and applications
- Protease and Inhibitor Mechanisms
- Animal testing and alternatives
- Neurobiology and Insect Physiology Research
- Photochromic and Fluorescence Chemistry
- Collagen: Extraction and Characterization
Inserm
2000
Centre Paul Broca
2000
University College London
2000
Centre National de la Recherche Scientifique
1988-1992
Laboratoire de Chimie Organique
1991
Différenciation et Communication Neuronale et Neuroendocrine
1989
Small, biologically active peptides (short sequences of amino acids) were first described about 40 years ago: TRH, angiotensin, vasopressin, oxytocin, bradykinin. Since then, many more have been isolated from mammalian tissue and organs, their activity investigated. Essentially, these molecules play a hormonal (messenger) role: released at one point in the body, they act specific receptor sites different locations organism. Mostly are transported site release to biological through blood or...
Abstract Background Extracellular matrices play a critical role in tissue structure and function aberrant remodelling of these is hallmark many age-related diseases. In skin, loss dermal collagens disorganization elastic fibre components are key features photoageing. Although the application some small matrix-derived peptides to aged skin has been shown beneficially affect vitro cell behaviour and, vivo, molecular architecture clinical appearance, discovery new lacked guiding hypothesis....
Summary This study was conducted to establish a new methodology for evaluating elements of dermal extracellular matrix ( ECM ), epidermal–dermal junction EDJ and effects molecules which can modulate their synthesis. is based on matrix‐assisted laser desorption/ionization mass spectrometric imaging MALDI ‐ MSI ). In vivo reflectance confocal microscopy in RCM ) echography were also used. Using immunohistochemistry methods explants, age‐related modification data obtained selected proteins...
ABSTRACT Most animal experiments on cosmetics safety are prohibited and since March 2013, this obligation includes sensitization tests. However, until now there has been no validated alternative in vitro method. In work, 400 compounds used the cosmetic industry were selected to cover greatest diversity of structures, biological activities sensitizing potential. These molecules submitted a series tests aimed at reproducing essential steps distinguish between irritations, i.e., transcutaneous...
The cholecystokinin-8 (CCK-8)-inactivating peptidase is a serine which has been shown to be membrane-bound isoform of tripeptidyl II (EC 3.4.14.10). It cleaves the neurotransmitter CCK-8 sulfate at Met−Gly bond give Asp-Tyr(SO3H)-Met-OH + Gly-Trp-Met-Asp-Phe-NH2. In seeking reversible inhibitor this peptidase, enzymatic binding subsites were characterized using fluorimetric assay based on hydrolysis artificial substrate Ala-Ala-Phe-amidomethylcoumarin. A series di- and tripeptides having...
Skin extracellular matrix (ECM) is a dense and well-organized structure produced by fibroblasts. This ECM transduces environmental mechano-signals to cell nucleus through the integrin-actin complex, thus triggering protein syntheses. The aim of this study was discover novel peptide, structurally related dermal matrikines, that promotes syntheses components.Screening tests with 120 peptides were carried out using normal human fibroblasts (HF). As result, one candidate interest isolated,...
Summary The exogenous application of small peptides can beneficially affect clinical skin appearance (wrinkles) and architecture (collagen elastic fibre deposition epidermal thickness). However, the discovery new bioactive has not been underpinned by any guiding hypothesis. As endogenous extracellular matrix (ECM)-derived produced during tissue remodelling act as molecular signals influencing cell metabolism, we hypothesised that protease cleavage site prediction could identify putative...
Abstract The extracellular matrices (ECMs) of mammalian tissues play important roles in mediating and maintaining tissue function. However, aberrant progressive remodelling ECM components is a key feature the pathology ageing many organs, including skin. Crucially, these degradative processes not only impair function, but may also release peptide fragments, known as matrikines, with cell signalling capabilities. In addition to endogenously produced exogenously applied bioactive peptides,...
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Abstract Three possibilities are pointed out for amino acid synthesis using enantioselective electrophilic processes: 1. carboxylation is exemplified by the of optically enriched esters such as (IV) from Schiff base (I) and reagents (II) (III); 2. in an alkylation process, bases (V) converted to acids (VII) (VI) bearing a chiral leaving group with enantiodifferentiating ability; 3. protonation procedure used third method, i.e. aldimine (IX) (available racemate (VIII)) deprotonated means LDA;...