A5045415621- Renal Diseases and Glomerulopathies
- Autoimmune Bullous Skin Diseases
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Head and Neck Surgical Oncology
- Urticaria and Related Conditions
- Chronic Kidney Disease and Diabetes
- Systemic Lupus Erythematosus Research
- Systemic Sclerosis and Related Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cell Adhesion Molecules Research
- Protease and Inhibitor Mechanisms
- Mast cells and histamine
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Cervical Cancer and HPV Research
- Pancreatic and Hepatic Oncology Research
- Platelet Disorders and Treatments
- Vasculitis and related conditions
- Cancer and Skin Lesions
- Peptidase Inhibition and Analysis
- Epigenetics and DNA Methylation
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Neuroendocrine Tumor Research Advances
- Drug-Induced Adverse Reactions
Medical University of Lodz
2014-2024
Central Clinical Hospital
2021
Memorial Hospital of South Bend
2013
Arkana Laboratories
2003-2012
Polish Mother’s Memorial Hospital Research Institute
2011
Morpho (United States)
2005
Jagiellonian University
1999
Head Office of Geodesy and Cartography
1994
Cadmium (Cd) is an environmental toxicant and endocrine disruptor in humans animals, recent studies have illustrated that the uterus exceedingly sensitive to Cd toxicity. The aim of study was investigate influence subchronic (90 days) oral exposure daily doses 0.09-4.5 mg/kg b.w. on balance sex hormones by estimating estradiol (E 2 ) progesterone (P) concentrations plasma comparison with effects 17 β -E . Additionally, uterine weight, histopathological changes ovaries, regularity estrous...
Cadmium (Cd) is regarded as a potential endocrine disruptor. However, the exact mechanism by which this metal may interfere with reproductive system has not yet been elucidated. The present study aimed to investigate effect of subacute Cd oral administration at daily doses 0.09, 1.8, and 4.5 mgCd/kg b.w. impact on sex hormones (estradiol (E2) progesterone (P)) in plasma uterus, well estrous cyclicity histopathological changes uterine ovary female rats after terminating exposure prolonged...
The immunoexpression of the PD-L1 and number immune infiltrating cells have been shown to be a significant prognostic factors in various human cancers. Immunohistochemical method was used examine Foxp3+, CD4+, CD8+ 78 cases oral squamous cell carcinomas (OSCCs): with better prognosis - OSCCBP (n = 37), poorer OSCCPP 41), 18 normal mucosa as control. mean Foxp3+ significantly increased group comparison control groups. CD4+ were more numerous group. In both groups there positive correlations...
This is the first report on epidemiology of biopsy-proven kidney diseases in Poland.The Polish Registry Renal Biopsies has collected information all (n = 9394) native renal biopsies performed Poland from 2009 to 2014. Patients' clinical data at time biopsy, and histopathological diagnoses were used for epidemiological clinicopathologic analysis.There was a gradual increase number per million people (PMP) year 2009-14, starting 36 PMP 44 A considerable variability between provinces mean...
A family of eleven proteins comprises the Janus kinases (JAK) and signal transducers activators transcription (STAT) signaling pathway, which enables transduction from cytokine receptor to nucleus activation target genes. Irregular functioning cascade may contribute pathogenesis autoimmune diseases; however, there are no reports concerning bullous diseases yet be published. The aim this study was evaluate expression constituting JAK/STAT pathway in skin lesions perilesional area dermatitis...
Overexpression of inhibitory checkpoint PD1/PD‐L1 plays an important role in carcinogenesis and patients prognosis. 70 cases oral squamous cell carcinoma (OSCC), 23 leukoplakia (OLK), 19 control were immunohistochemically stained with anti‐PD‐L1, ‐CD8, ‐CD163 antibodies. PD‐L1 was expressed on dysplastic subepithelial infiltrating cells OLK as well cancer tumor‐infiltrating OSCC. In OSCC, immunoexpression significantly increased comparison to OLK, groups. The correlative study showed...
Dermatitis herpetiformis (DH) and bullous pemphigoid (BP) are skin diseases associated with eosinophilic neutrophilic infiltrations. Although cytokines critical for the inflammatory process, there single findings concerning concentration of IL-17 in diseases. The goal this study was to assess expression DH BP patients. Skin biopsies were taken from 10 DH, 14 patients healthy subjects. localization studied by immunohistochemistry serum measured immunoassays. Expression epidermis influxed...
Background: Patients with aspirin‐hypersensitive rhinosinusitis/asthma suffer from a severe form of hyperplastic rhinosinusitis recurrent polyposis. We aimed to assess the presence apoptotic cells in nasal polyps (AH) and aspirin‐tolerant (AT) patients as related characteristics local inflammation. Methods: Nasal obtained 16 AH 36 AT (17 atopic 19 nonatopic) were stained for eosinophils metachromatic cells, parallel immunocytochemistry was performed detect CD45RO+, HLA‐DR+, CD8+ CD68+...
Mast cells constitute a significant proportion of infiltrating nasal polyp tissue, and epithelial may release stem cell factor (SCF), cytokine with chemotactic survival activity for mast cells. We aimed to assess the expression SCF in human (NPECs) as related patients’ clinical phenotypes. Nasal tissues were obtained from 29 patients [including nine aspirin (ASA)‐hypersensitivity 12 bronchial asthma] undergoing polypectomy obstruction. Epithelial following 6‐week culture polyps explants. The...
The pathogenesis of rhinosinusitis in aspirin-exacerbated airway disease is closely linked to the disequilibrium arachidonic acid metabolism. Although considerable amounts data concerning impaired eicosanoid production are available, precise mechanism and still unknown. aim present study was assess expression enzymes belonging cascade receptors for arachidonate derivative metabolites nasal polyps from aspirin- hypersensitive (AH) aspirin-tolerant (AT) patients with rhinosinusitis.Cells...
Cancer stem cells (CSC) play an important role in pancreatic carcinogenesis and prognosis. The study aimed at examining the expression of CD24, CD44, CD133 human PDAC CP order to evaluate its clinicopathological correlations clinical significance. Surgical specimens from 23 patients with 15 chronic pancreatitis after resection were stained antibodies. intensity staining was scored 0 (negative) 3 (strongly positive). Results . Mean CD24 score 1.38 ± 0.76 significantly higher than that CP:...
<i>Background:</i> There is a paucity of epidemiological data on biopsy-proven glomerulonephritis (GN) in Poland. The aim this study was to assess the epidemiology renal diseases based histological diagnosis region Central Poland over last two decades. <i>Methods:</i> Retrospective analysis results 746 consecutive native kidney biopsies performed Caucasian adults from 1990 2010 single tertiary nephrology center serving an area <i>Results:</i> Primary GN...
Background The prognosis of human malignancies has been shown to depend on immunological parameters, such as macrophage polarization (M1 and M2). In this study, we identify the phenotype macrophages, investigate an involvement infiltrated T cells that participate in oral leukoplakia (OLK), squamous cell carcinoma (OSCC). Methods Immunohistochemical method was used examine number CD68 + , CD163 (M2), iNOS (M1) CD4 CD8 CCR4 (Th2), CCR5 (Th1) 102 cases OSCC: without metastases—OSCC M(−) (n =...
Bullous pemphigoid (BP) and dermatitis herpetiformis (DH) are skin diseases associated with inflammation. However, few findings exist concerning the role of mast cells in autoimmune blistering disease. Skin biopsies were taken from 27 BP 14 DH patients, as well 20 healthy individuals. Immunohistochemistry was used to identify localization cell expression TNF α MMP9 lesions perilesional skin. The serum concentrations , MMP9, chymase, tryptase, PAF, IL-4 measured by immunoassay. epidermis...
We studied the effects of size and time after rabbit supraspinatus tenotomy (group A - small tenotomy, group B large tenotomy) on muscle morphometric changes in 48 rabbits. Animals were killed 6 (subgroups A1 B1), 12 A2 B2) 24 weeks A3 B3) tendon detachment. Statistically significantly greater increases interstitium volume noted subgroups A1-A3 B1-B3 than controls. Reductions type I II fiber diameters mainly due to length observation. However, statistically significant differences comparison...
The clinical significance of the immunoexpression survivin in prostate cancer and its correlation with biological aggressiveness remains unclear. Therefore, present study was undertaken to compare (PCa) benign prostatic hyperplasia (BPH) as well determine whether this could correlate Gleason score, proliferation activity specific antigen (PSA) levels. needle biopsies from 28 patients elevated serum PSA levels were studied. As a control, 12 diagnosed BPH used. evaluated semiquantitatively,...
Recent investigations have taken into account the role of mast cells in prostate cancer formation, analyzing their dual functions (as tumour growth promoters and inhibitors). The aim our study was to compare cell infiltration microvessel density benign hyperplasia. We also attempted find possible relationships among density, Gleason score, as well serum levels prostate-specific antigen (PSA).The investigation confined evaluations material from needle biopsies, carried out 26 patients with...
Inverted papillomas are a unique group of locally aggressive benign epithelial neoplasms in the nasal cavity and paranasal sinuses arising from Schneiderian mucosa. Metallothioneins sulfhydryl-rich heavy metal-binding proteins required for metal toxicity protection regulation biological mechanisms including proliferation invasion. The goal this study was to identify three SNPs at loci -5 A/G (rs28366003) -209 (rs1610216) core promoter region locus +838 C/G (rs10636) 3'UTR MT2A gene with IP...