A5056170090- Renal Transplantation Outcomes and Treatments
- Cytomegalovirus and herpesvirus research
- Urinary Tract Infections Management
- Diet and metabolism studies
- Cancer, Lipids, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Cancer Genomics and Diagnostics
- Gallbladder and Bile Duct Disorders
- Bariatric Surgery and Outcomes
- Genetic factors in colorectal cancer
- Healthcare cost, quality, practices
- Polyomavirus and related diseases
- Esophageal and GI Pathology
- Growth Hormone and Insulin-like Growth Factors
- Drug-Induced Adverse Reactions
- T-cell and B-cell Immunology
- Global Health Care Issues
- Thyroid Disorders and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Chronic Kidney Disease and Diabetes
- COVID-19 and Mental Health
- Health Systems, Economic Evaluations, Quality of Life
- Pancreatic and Hepatic Oncology Research
- Immune Cell Function and Interaction
- Innovations in Medical Education
Gdańsk Medical University
2015-2024
Medical University of Warsaw
2015-2024
University Clinical Centre
2020
Polish Academy of Sciences
2019-2020
Institute of Immunology
2019-2020
Male sex is a risk factor for colorectal cancer (CRC) with higher illness burden and earlier onset. Thus, we hypothesized that loss of chromosome Y (LOY) in the tumor micro-environment (TME) might be involved oncogenesis. Previous studies show LOY circulating leukocytes aging men was associated shorter survival non-hematological cancer, as well CD4 + T-lymphocytes prostate vs. controls. However, nothing known about infiltrating TME address this aspect here. We studied frequency functional...
Abstract We would like to demonstrate the difficulty of treatment in a patient after kidney transplantation (KTX) who developed chronic urinary tract infection (UTI) with multi‐drug resistant ESBL‐producing Klebsiella pneumoniae . The underwent several interventions including supportive therapy bacteriophages. This article presents case 60‐year‐old KTX repeatedly admitted hospital recurrent UTIs caused by showing variable susceptibility carbapenems and full colistin only. was performed due...
Subjects with morbid obesity have low levels of serum branched-chain fatty acids (BCFAs), which correlate inversely insulin resistance, hypertriglyceridemia, and inflammation. Recent evidence suggests BCFAs are produced during amino acid (BCAA) catabolism in human adipose tissue. Elevated concentrations BCAAs associated resistance.In this single-center study, we evaluated the effect one anastomosis gastric bypass (OAGB) on circulating BCFA BCAA. Moreover, determined expression genes involved...
This is the first report on epidemiology of biopsy-proven kidney diseases in Poland.The Polish Registry Renal Biopsies has collected information all (n = 9394) native renal biopsies performed Poland from 2009 to 2014. Patients' clinical data at time biopsy, and histopathological diagnoses were used for epidemiological clinicopathologic analysis.There was a gradual increase number per million people (PMP) year 2009-14, starting 36 PMP 44 A considerable variability between provinces mean...
Longer life expectancy is associated with an increasing prevalence of kidney disease. Aging itself may cause renal damage, but the spectrum disorders that affect elderly patients diverse. Few studies, mostly form US, Asia and West Europe found differences in some types diseases between younger based on biopsy findings, varied proportion glomerulopathies arterionephrosclerosis as a dominant injury found. Here, for first time Eastern we analyzed native findings their relationship to clinical...
Fatty acid synthase (FASN) provides palmitate for cell membrane formation in colorectal cancer (CRC) cells, however, is also available the blood of CRC patients. The aim this study was to examine whether orlistat, a FASN inhibitor, able attenuate growth despite availability extracellular palmitate.Palmitate concentrations were measured serum from patients and healthy controls. HT-29 cells treated with orlistat palmitate.Treatment caused dose-dependent inhibition proliferation. In turn,...
Vaccination is one of the most useful preventive interventions in healthcare. The purpose our study was to gain overview opinions, knowledge, and engagement vaccination practices among medical students (MS) junior doctors (JD) Europe. survey distributed from March 2016 until August via e-mail social media European Medical Students’ Association. In total, 1821 responses MS JD 34 countries region were analysed. majority respondents agreed that vaccines are (98.7%) effective (97.2%). Although...
Accumulating evidence indicates alterations in lipid metabolism and composition neoplastic tissue. Earlier nuclear magnetic resonance studies showed that the contents of major groups, such as triacylglycerols, phospholipids cholesterol, are changed colon cancer tissue.In this study, a more detailed analysis lipids tumor adjacent tissues from colorectal patients, using liquid chromatography-mass spectrometry, allowed for comparison 199 different between tissue principal component...
Cold ischemia time (CIT), the interval between tissue excision and preservation, is a critical preanalytical variable that profoundly impacts gene expression profiles. Variability in CIT can lead to inconsistent transcriptomic results, making study interpretation challenging undermining reproducibility biomedical research. Our aimed evaluate impact of on cancer-related genes, particularly these involved hypoxia, apoptosis, epithelial-to-mesenchymal transition (EMT). We performed RNA...
To compare the effect of RYGB and OAGB on patients after failed treatment obesity by laparoscopic sleeve gastrectomy (LSG). A case–control study based a prospectively maintained database reoperated LSG, which included 33 who underwent conversion 47 conversion. The mean %EBWL 5-year follow-up for RYGBc vs OAGBc was 84.04% 72.95% (p = 0.2176), respectively. Complete long-term diabetes remission observed significantly more frequently in than group (97.3% 33%; p 0.035). There were no other...
BACKGROUND Electronic nicotine delivery systems, including electronic cigarettes (e-cigarettes) are gaining popularity. The objectives of this study were to assess the knowledge and beliefs about e-cigarettes among physicians in Poland. MATERIAL AND METHODS A questionnaire-based survey was conducted attending mandatory courses delivered at School Public Health, Centre Postgraduate Medical Education (Warsaw, Poland). questionnaire included 24 questions concerning attitudes e-cigarettes....
Obesity is associated with alterations in serum fatty acid profiles. One-anastomosis gastric bypass a type of bariatric surgery used the treatment morbid obesity. The aim this study was to establish if, between 6 and 9 months after procedure, composition patients normalizes values similar healthy, lean population.The included 46 that underwent surgical for obesity one-anastomosis bypass. determined using gas chromatography-mass spectrometry. Principal component analysis conducted detect...
Corynebacterium coyleae is part of the commensal microflora skin, urethra, mucous membranes, and genital tract. Isolates from patients with urinary tract infection (UTI) were reported, but pathogenic potential this species has not been defined yet. The aim study to determine whether C. could be etiological agent UTI analyze its antibiotic susceptibility. Urine samples cultured quantitatively according accepted laboratory procedures. identification bacterial isolates was carried out using...
Background: Urinary tract infections (UTIs) are the most common bacterial among kidney transplant (KTX) recipients. The purpose of this study was to analyze antimicrobial resistance (AMR) in four pathogens responsible for UTIs KTX recipients and determine risk factors (RF) same group. Methods: Analyzed antibiograms were based on urine samples positive growth 105 colony-forming units (CFU)/mL obtained from hospitalized adult presenting with UTI symptoms upon admission center years 2011-2018....
Colorectal cancer (CRC) is often diagnosed at an advanced stage due to the invasiveness of colonoscopy; thus, non-invasive CRC diagnostics are desirable. associated with lipid alterations. We aimed verify whether fatty acid (FA) profiles in patients may serve as a potential diagnostic tool for diagnosis. FA were assayed by GC-MS tissue, paired normal mucosa and serum from healthy controls. The levels very long FAs – VLCFAs (26:0, 28:0 26:1) most highly increased tissue compared colon mucosa....
Background Vitamin D deficiency occurs in as much 90-95% of the Polish population, although this condition is known to cause negative long-term health implications. The role medical doctors advising proper supplementation, monitoring and correcting levels 25-hydroxyvitamin individuals great importance should be used help mitigate its common deficits. aim study was evaluate knowledge, attitudes practices physicians regarding vitamin supplementation order identify areas for improvement...
The progress in translational cancer research relies on access to well-characterized samples from a representative number of patients and controls. rationale behind our biobanking are explorations post-zygotic pathogenic gene variants, especially non-tumoral tissue, which might predispose cancers. targeted diagnoses carcinomas the breast (via mastectomy or conserving surgery), colon rectum, prostate, urinary bladder cystectomy transurethral resection), exocrine pancreatic carcinoma as well...
BACKGROUND:Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare hypersensitivity involving the skin various visceral organs; kidneys are second most affected organ. Many drugs reported to be associated DRESS, particularly antiepileptic agents allopurinol. Certain human leukocyte antigen (HLA) haplotypes, in combination particular drug, can further contribute an increased risk of DRESS. Symptoms often develop 2 8 weeks after drug initiation. If diagnosis delayed,...
Antimicrobial resistance (AMR) is an urgent public health issue. The role of medical doctors in proper antibiotic use crucial. aim this study was to evaluate the knowledge and practices Polish antimicrobial prescribing resistance. group consisted 504 with average age 32.8 ± 5.9 years, mostly women (65%). paper questionnaire developed on basis a survey tool by European Centre for Disease Prevention Control (ECDC) Public Health England (PHE). According our study, physicians were aware that:...
BACKGROUND:The study aim was to assess the prevalence of depression, anxiety, stress, and insomnia among resident doctors in Poland during COVID-19 pandemic. MATERIAL AND METHODS:The online anonymous survey conducted Polish attending obligatory specialization courses organized by Center Postgraduate Medical Education between 2020 2021. The psychological impact measured using Depression, Anxiety, Stress Scale (DASS-21). sleep problems were assessed Insomnia Severity Index (ISI). RESULTS:Among...