A5016475460- Pituitary Gland Disorders and Treatments
- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Adrenal and Paraganglionic Tumors
- Head and Neck Surgical Oncology
- Growth Hormone and Insulin-like Growth Factors
- Neuroblastoma Research and Treatments
- Neuroendocrine Tumor Research Advances
- Spinal Fractures and Fixation Techniques
- Adrenal Hormones and Disorders
- Spine and Intervertebral Disc Pathology
- Neurofibromatosis and Schwannoma Cases
- Traumatic Brain Injury and Neurovascular Disturbances
- Brain Metastases and Treatment
- Congenital Diaphragmatic Hernia Studies
- Management of metastatic bone disease
- Cerebrospinal fluid and hydrocephalus
- Cancer, Hypoxia, and Metabolism
- MRI in cancer diagnosis
- Spinal Dysraphism and Malformations
- Neurosurgical Procedures and Complications
- Ovarian cancer diagnosis and treatment
- Intracranial Aneurysms: Treatment and Complications
- Retinoids in leukemia and cellular processes
- Spinal Hematomas and Complications
Sorbonne Université
2021-2025
Assistance Publique – Hôpitaux de Paris
2021-2025
Pitié-Salpêtrière Hospital
2021-2025
Centre National de la Recherche Scientifique
2006-2025
Inserm
2022-2025
Université Paris Cité
2022-2025
Institut Cochin
2022-2025
Institut du Cerveau
2022-2024
Hôpital Lariboisière
2024
Hôpital Foch
2007-2022
Mutations in the isocitrate dehydrogenase (IDH) enzyme affect 40% of gliomas and represent a major diagnostic prognostic marker. The goals this study were to evaluate performance noninvasive magnetic resonance spectroscopy (MRS) methods determine IDH status patients with brain through detection oncometabolite 2-hydroxyglutarate (2HG) compare these DNA sequencing tissue 2HG analysis.Twenty-four subjects suspected diagnosis low-grade glioma included prospectively study. For all subjects, MRS...
Abstract Context Aggressive pituitary tumors (APTs) are characterized by unusually rapid growth and lack of response to standard treatment. About 1% 2% develop metastases being classified as carcinomas (PCs). For unknown reasons, the corticotroph overrepresented among APTs PCs. Mutations in alpha thalassemia/mental retardation syndrome X-linked (ATRX) gene, regulating chromatin remodeling telomere maintenance, have been implicated development several cancer types, including neuroendocrine...
After temozolomide failure, no evidence-based treatment is available for pituitary carcinomas (PCs) and aggressive tumors (APTs). To date, only 12 cases treated with immune-checkpoint inhibitors (ICIs) have been published, showing encouraging efficacy. Predictive factors of response are lacking. Here, we aimed to assess the real-life efficacy predictors ICIs in PCs APTs.This study a multicentric, retrospective, observational cohort study, including all APTs France up March 2022. PD-L1...
Abstract Objective Targeted therapy (TT) with BRAF/MEK inhibitors has emerged as a potential treatment in papillary craniopharyngiomas (PCPs). However, standardized data on large cohorts are lacking. Our study aimed to assess real-life efficacy and safety of inhibition patients PCPs. Design Retrospective French multicenter involving BRAF V600E–mutated PCP patients, treated inhibitor combination dabrafenib trametinib, from April 2019 July 2023. Methods response clinical outcomes were assessed...
Summary Objective Silent corticotroph adenomas ( SCA s) present as nonfunctional pituitary tumours in routine pre‐operative evaluation. The objective of this study was to evaluate the diagnostic accuracy MRI T 2‐weighted sequences for detecting subtype pre‐operatively. Design were retrospectively evaluated patients with and two control groups: clinically manifest macroadenomas CSM gonadotroph NFGM s). All selected from a registry 1096 whom transsphenoidal surgery performed same tertiary...
Microprolactinomas are currently treated with dopamine agonists. Outcome information on microprolactinoma patients by surgery is limited. This study reports the first large series of consecutive non-invasive pituitary and evaluates efficiency safety this treatment.Follow-up a cohort surgery.Between January 2008 October 2020, 114 adult pure microprolactinomas were operated in single tertiary expert neurosurgical department, using an endoscopic endonasal transsphenoidal approach. Eligible...
Introduction Pituitary adenomas (PAs) are common, usually benign tumors of the anterior pituitary gland which, for most part, have no known genetic cause. PAs associated with major clinical effects due to hormonal dysregulation and tumoral impingement on vital brain structures. PAM encodes a multifunctional protein responsible essential C-terminal amidation secreted peptides. Methods Following identification loss-of-function variant (p.Arg703Gln) in peptidylglycine a-amidating monooxygenase...
Abstract Objective A somatic mutational hotspot in the SF3B1 gene was reported lactotroph tumours. The aim of our study to examine prevalence driver variants a multicentre independent cohort patients with tumours and correlate clinical data. Design methods This retrospective, involving 282 (including 6 metastatic tumours) from 8 European centres. We screened exon 14 for using Sanger sequencing correlated clinicopathological Results detected seven tumours: c.1874G > (p.Arg625His) (n =...
Abstract Context Outcome of craniopharyngioma is related to its locoregional extension, which impacts resectability and the risk surgical complications. To maximize resection minimize complications, optic tract localization, temporal lobe hypothalamic involvement are essential factors for management. Objective assess outcome craniopharyngiomas depending on their relation hypothalamus location. Methods We conducted a retrospective analysis 79 patients with who underwent surgery from 2007...
OBJECTIVE The present study evaluates the effectiveness of 2 surgical procedures, shunting and untethering, for posttraumatic syringomyelia. METHODS We retrospectively reviewed medical charts all patients with syringomyelia in our department. Shunting was performed before 1997; after 1997, we used arachnoidolysis untethering. RESULTS 15 patients, 19 underwent arachnoidolysis. Statistical analysis found that groups did not differ age or initial clinical radiological presentation. All suffered...
D-2-hydroxyglutarate (2HG) characterizes
Bacterial meningitis is still associated with a high mortality, mainly because of cerebral herniation as result increased intracranial pressure. Published data stress the necessity an early diagnosis and immediate start antibiotic therapy. Nevertheless, there are only few reports in which therapeutic strategy was based on monitoring reduction pressure (ICP). We report one case bacterial caused by Neisseria meningitidis initial ICP value 60 mmHg, treated large hemicraniectomy ventriculostomy,...
Effective strategies are required to ensure optimal management of the crucial closure step in endoscopic pituitary surgery. Many surgical techniques have been reported but no significant consensus has defined.Between January 2006 and March 2022, 3015 adult patients with adenomas were operated on by a single expert neurosurgical team, using mononostril endonasal approach. Based preoperative risk factors operative findings, detailed strategy was used. Body mass index >40, sellar floor lysis,...