A5008430586- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Muscle metabolism and nutrition
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Dietary Effects on Health
- TGF-β signaling in diseases
- Adrenal and Paraganglionic Tumors
- Adrenal Hormones and Disorders
- Neurological disorders and treatments
- Exercise and Physiological Responses
- Silk-based biomaterials and applications
- Circadian rhythm and melatonin
- Studies on Chitinases and Chitosanases
- Genetics, Aging, and Longevity in Model Organisms
- GDF15 and Related Biomarkers
- Parkinson's Disease Mechanisms and Treatments
- Nuclear Receptors and Signaling
- Glioma Diagnosis and Treatment
- Nutrition and Health in Aging
- Muscle Physiology and Disorders
- Coffee research and impacts
- Invertebrate Immune Response Mechanisms
- Neuroblastoma Research and Treatments
Oslo University Hospital
2019-2025
University of Oslo
2020-2025
Charles University
2011-2015
National Institute of Occupational Health
2010
GDF15 is an established biomarker of cellular stress. The fact that it signals via a specific hindbrain receptor, GFRAL, and mice lacking manifest diet-induced obesity suggest may play physiological role in energy balance. We performed experiments humans, mice, cells to determine if how nutritional perturbations modify expression. Circulating levels very modest changes response moderate caloric surpluses or deficits differentiating from classical intestinally derived satiety hormones leptin....
Glycogen is the storage form of carbohydrates in mammals. In humans majority glycogen stored skeletal muscles (∼500 g) and liver (∼100 g). Food supplied larger meals, but blood glucose concentration has to be kept within narrow limits survive stay healthy. Therefore, body cope with periods excess without supplementation. Healthy persons remove rapidly when excess, insulin-stimulated disposal reduced insulin resistant type 2 diabetic subjects. During a hyperinsulinemic euglycemic clamp,...
Abstract Context Aggressive pituitary tumors (APTs) are characterized by unusually rapid growth and lack of response to standard treatment. About 1% 2% develop metastases being classified as carcinomas (PCs). For unknown reasons, the corticotroph overrepresented among APTs PCs. Mutations in alpha thalassemia/mental retardation syndrome X-linked (ATRX) gene, regulating chromatin remodeling telomere maintenance, have been implicated development several cancer types, including neuroendocrine...
Caffeine and theophylline inhibit phosphatidylinositol 3-kinase (PI3-kinase) activity insulin-stimulated protein kinase B (PKB) phosphorylation. Insulin-stimulated glucose uptake involves PI3-kinase/PKB, the aim of present study was to test hypothesis that caffeine in skeletal muscles.Rat epitrochlearis muscles soleus strips were incubated with insulin different concentrations for measurement uptake, force development PKB The effect also investigated stimulated electrically.Caffeine...
Epinephrine increases glycogen synthase (GS) phosphorylation and decreases GS activity but also stimulates breakdown, low content normally activates GS. To test the hypothesis that directly regulates phosphorylation, breakdown was stimulated in condition with decreased activation. Saline or epinephrine (0.02 mg/100 g rat) injected subcutaneously Wistar rats (∼130 g) (24-h-fasted), normal (normal diet), high (fasted-refed), epitrochlearis muscles were removed after 3 h incubated ex vivo,...
Aim Chitinase-3-like protein 1 (CHI3L1) is involved in tissue remodelling and inflammatory processes. Plasma levels are elevated patients with insulin resistance T2DM. We recently showed that CHI3L1 its receptor protease-activated 2 (PAR-2) expressed skeletal muscle. Activation of PAR-2 by protects against TNF-α-induced inflammation resistance. However, the effect exercise on signalling remains unknown. The aim this work was to study impact production CHI3L1/PAR-2 muscle growth repair....
Abstract Humans have, throughout history, faced periods of starvation necessitating increased physical effort to gather food. To explore adaptations in muscle function, 13 participants (7 males and 6 females) fasted for seven days. They lost 4.6 ± 0.3 kg lean 1.4 0.1 fat mass. Maximal isometric isokinetic strength remained unchanged, while peak oxygen uptake decreased by 13%. Muscle glycogen was halved, expression electron transport chain proteins unchanged. Pyruvate dehydrogenase kinase 4...
Long-standing growth hormone (GH) excess causes the skeletal clinical signs of acromegaly with typical changes in bone geometry, including increased cortical thickness (CBT). However, a high prevalence and incidence vertebral fractures has been reported. The aim this study was to assess course dimensions hip by comparing patients clinically nonfunctioning pituitary adenomas (NFPAs) at baseline 1 year after surgery (1-year PO) longitudinal cohort study. DXA performed (n = 56) NFPA 47). CBT...
Abstract Context Gonadotroph pituitary neuroendocrine tumors (PitNETs) can express follicle-stimulating hormone (FSH) and luteinizing (LH) or be negative, but they rarely secrete hormones. During tumor development, epithelial cells develop a mesenchymal phenotype. This process is characterized by decreased membranous E-cadherin translocation of to the nucleus. Estrogen receptors (ERs) regulate both FSH expression secretion. Whether status patients with gonadotroph PitNETs regulated...
Background: Generally, food intake occurs in a three-meal per 24 h fashion with in-between meal snacking. As such, most humans spend more than ∼ 12-16 day the postprandial state. It may be reasoned from an evolutionary point of view, that human body is physiologically habituated to less frequent meals. Metabolic flexibility (i.e., reciprocal changes carbohydrate and fatty acid oxidation) characteristic metabolic health reduced by semi-continuous feeding. The effects time-restricted feeding...
Here, we report the investigation of transforming growth factor beta-receptor 3 like (TGFBR3L), an uncharacterised pituitary specific membrane protein, in non-neoplastic anterior gland and neuroendocrine tumours. A polyclonal antibody produced within Human Protein Atlas project (HPA074356) was used for TGFBR3L staining combined with SF1 FSH a 3-plex fluorescent protocol, providing more details about cell lineage specificity expression. cohort 230 tumours were analysed. In subgroup previously...
Transforming growth factor-beta receptor 3-like (TGFBR3L) is a pituitary enriched membrane protein selectively detected in gonadotroph cells. TGFBR3L named after transforming 3 (TGFBR3), an inhibin A co-receptor mice, due to sequence identity the C-terminal region. We aimed characterize detection well-characterized, prospectively collected cohort of non-functioning neuroendocrine tumours (NF-PitNETs) and correlate it clinical data.144 patients operated for clinically NF-PitNETs were...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)