A5066689391- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Nutritional Studies and Diet
- Potato Plant Research
- Cardiovascular Health and Disease Prevention
- Cardiac pacing and defibrillation studies
- Autoimmune and Inflammatory Disorders Research
- Cardiac Imaging and Diagnostics
- Blood Pressure and Hypertension Studies
- Folate and B Vitamins Research
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac Health and Mental Health
- Adipose Tissue and Metabolism
- Antioxidant Activity and Oxidative Stress
- Nutrition and Health in Aging
- Effects and risks of endocrine disrupting chemicals
- Adolescent and Pediatric Healthcare
- Chronic Kidney Disease and Diabetes
- Cardiovascular Disease and Adiposity
- Acute Myocardial Infarction Research
- Heart Rate Variability and Autonomic Control
- Birth, Development, and Health
- Liver Disease Diagnosis and Treatment
- Cardiac Arrhythmias and Treatments
Nanjing Medical University
2019-2025
Jiangsu Province Hospital
2019-2024
Weatherford College
2020
Beijing Chao-Yang Hospital
2018
Capital Medical University
2018
Background Systemic oxidative stress is involved in the development of hypertension, whereas carotenoids are a group natural antioxidants. Our study aims to evaluate relationships between serum concentrations major and mortality hypertensive adults. Methods Results Data on 5 from National Health Nutrition Examination Survey (NHANES) III NHANES 2001-2006 were included. Outcome measures (all-cause cardiovascular mortality) identified Death Index through December 31, 2019. Multiple Cox...
Previous findings have indicated the potential benefits of Chinese traditional medicine Qiliqiangxin (QLQX) in heart failure. Here we performed a double-blind, randomized controlled trial to evaluate efficacy and safety QLQX patients with failure reduced ejection fraction (HFrEF). This multicenter trial, conducted 133 hospitals China, enrolled 3,110 HFrEF NT-proBNP levels ≥450 pg ml
Objective Systemic inflammation is associated with a poor prognosis in acute heart failure (AHF). This study was to assess the long-term prognostic value of combining accessible inflammatory markers relation all-cause mortality patients AHF. Methods Consecutive AHF who were hospitalized between March 2012 and April 2016 at Department Cardiology First Affiliated Hospital Nanjing Medical University enrolled this prospective study. The LASSO regression model used select most valuable biomarkers...
The nonlinear associations of serum perfluoroalkyl acids (PFAAs) with hypertension and blood pressure have not been addressed. Cross-sectional data from 6967 adults (age ≥ 20 years) the 2003-2012 National Health Nutrition Examination Survey (NHANES) were analyzed. Hypertension was defined as an average systolic above 140 mmHg, diastolic 90 mmHg or self-reported use prescribed medicine for diagnosed hypertension. After multivariable adjustment, compared lowest tertile, odds ratios (ORs) 95%...
Myocardial fibrosis is associated with clinical ventricular tachyarrhythmia (VTA) events in patients non-ischaemic dilated cardiomyopathy (DCM). Subepicardial or mid-wall ring-like late gadolinium enhancement (LGE) has received increasing attention recent years. The aim of this study was to investigate the relationship between LGE and VTAs DCM.Patients diagnosed DCM who underwent cardiac magnetic resonance imaging at baseline were investigated. composite outcome occurrence defined as...
Diabetic cardiomyopathy (DCM) is a pathophysiological condition induced by diabetes mellitus that often causes heart failure (HF). However, their mechanistic relationships remain unclear. This study aimed to identify immune gene signatures and molecular mechanisms of DCM. Microarray data from the Gene Expression Omnibus (GEO) database patients with DCM were subjected weighted co-expression network analysis (WGCNA) modules. Core expression modules intersected database. We analyzed mapped...
The effect of aldehyde exposure on the cardiovascular system remains unclear. objective this study was to determine whether is associated with prevalence disease (CVD). We analyzed associations between aldehydes and CVD using data from 1962 adult participants in National Health Nutrition Examination Survey (NHANES) 2013 2014. Multivariable logistic regression restricted cubic spline models were used examine association CVD. 10.3%. After adjusting for confounding factors, including age, sex,...
Early-life cardiovascular risk factors (CVRFs) are known to be associated with target organ damage during adolescence and premature morbidity mortality adulthood. However, contemporary data describing whether the prevalence of CVRFs treatment control rates have changed limited. This study aimed examine temporal trends in prevalence, treatment, among US adolescents over past 2 decades.
BackgroundThere are strong association between remnant cholesterol (RC)/non-high density lipoprotein (NHDL-C) and increase cardiovascular (CV) risk. The aim of present study was to investigate the target lipid parameters (RC NHDL-C) risk CV mortality in general population.MethodsData set from an open database—National Health Nutrition Examination Surveys (NHANES) 2003–2014 were extracted (n = 14992). Kaplan-Meier, multivariable COX regression, restricted cubic spline (RCS)...
Ethylene oxide (EO) has been shown to associate with increased cardiovascular risk. This study aimed explore the relationship and its meditating factors between EO exposure major risk factor of obesity among general adult population.Cross-sectional data 3,220 participants from National Health Nutritional Examination Survey (NHANES) 2013-2016 were enrolled. Obesity was defined as body mass index (BMI) ≥30 kg/m2, abdominal waist circumference (WC) ≥102 cm in men ≥88 women. The association...
Abstract Background The influence of sarcopenic obesity (SO) on overall survival in older adults with hypertension has not been addressed. aim this study was to investigate the prevalence and mortality predictive value various body composition phenotypes, focusing mainly SO, hypertension. Methods We included 1105 hypertensive patients aged ≥ 60 years from National Health Nutrition Examination Survey 1999–2004. Sarcopenia broadly defined based low lean mass (LLM; as measured by dual-energy...
This study aimed to analyze immune-related genes and immune cell components in the peripheral blood of patients with acute myocardial infarction (AMI).Six datasets were obtained from GEO repository comprising 88 healthy samples 215 AMI samples. We performed weighted gene co-expression analysis (WGCNA) five machine learning (ML) methods identify construct diagnostic models. CIBERSORT algorithm was adopted for assessment degree infiltration. Finally, RT-PCR, immunofluorescence double...
Asymptomatic cerebral emboli (ACE) are commonly seen on magnetic resonance imaging (MRI) after atrial fibrillation ablation, but the incidence in previous studies varies widely. No data exists to compare effects of different diffusion-weighted (DWI) settings detecting ablation-related ACE. This self-control study sought and characteristics ACE between high-resolution DWI conventional DWI.A total 55 consecutive patients referred for ablation December 2017 September 2018 were enrolled....
This study was designed to investigate the cardioprotective role of β-hydroxybutyrate (BHB) in heart failure with preserved ejection fraction (HFpEF) and underlying mechanism.A two-hit model a high-fat diet (HFD) Nω-nitrol-arginine methyl ester (L-NAME) used as an HFpEF model. The treatment group received weekly intraperitoneal injection (BHB). Cardiac function, inflammation, fibrosis were evaluated. CD3+CD4+Foxp3+ positive cells within myocardium quantified by flow cytometry. NADPH oxidase...
Inflammation is one of the major pathways in progression hypertension (HTN), and related inflammatory markers have demonstrated certain predictive values. The current study aimed to integrate these construct an prognostic scoring (IPS) system assess values IPS patients with HTN.A total 9846 adult participants HTN from NHANES 1999-2010 were enrolled followed up. Demographic characteristics laboratory results for 12 collected. LASSO-COX regression, Kaplan-Meier, restricted cubic spline COX...
The aim of present study was to investigate the association acrylamide (AA) hemoglobin biomarkers and serum lipids level in a general population. Data set our were extracted from an open database - National Health Nutrition Examination Surveys (NHANES) 2013–2016. In total 2899 participants enrolled. associations between AA parameters [hemoglobin adducts (HbAA) glycidamide (HbGA), HbAA HbGA (HbAA+HbGA), ratio (HbGA/HbAA)] lipid levels [total cholesterol (TC), triglyceride (TG), low-density...