A5101786694- Adipose Tissue and Metabolism
- Diabetes and associated disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Cutaneous Melanoma Detection and Management
- Metabolism, Diabetes, and Cancer
- Syphilis Diagnosis and Treatment
- Diabetes Management and Research
- melanin and skin pigmentation
- Pancreatic function and diabetes
- Skin and Cellular Biology Research
- Sexuality, Behavior, and Technology
- Asthma and respiratory diseases
- Nonmelanoma Skin Cancer Studies
- Diet and metabolism studies
- Cancer-related molecular mechanisms research
- Genetic and rare skin diseases.
- Lipid metabolism and biosynthesis
- Genetic Associations and Epidemiology
- Atherosclerosis and Cardiovascular Diseases
- Cancer Diagnosis and Treatment
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cancer, Hypoxia, and Metabolism
- Vasculitis and related conditions
- Phagocytosis and Immune Regulation
- Mindfulness and Compassion Interventions
First Affiliated Hospital of Wannan Medical College
2022-2025
Leshan Normal University
2025
Peking Union Medical College Hospital
2008-2024
Wannan Medical College
2023-2024
Wuxi No.2 People's Hospital
2022
Nanjing Medical University
2022
Southern Medical University
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2008-2021
Institute of Hematology & Blood Diseases Hospital
2021
First Affiliated Hospital of Anhui Medical University
2020-2021
This study aimed to investigate biological markers in subacute cutaneous lupus erythematosus (SCLE). The tandem mass tag (TMT)-labelling proteomics method was used explore differentially expressed proteins between SCLE lesions and normal skin tissues. differences transcriptomic data tissues were analysed from the GEO database (GSE81071, GSE109248 GSE112943). peripheral blood mononuclear cells (PBMCs) of patients with systemic (SLE) controls (GSE81622 GSE154851). 35 healthy controls, 30...
Cyberbullying victimization (CV) has been linked to numerous adverse psychological outcomes among adolescents. While previous research established associations between CV and negative including depression, diminished self-esteem, academic burnout, the potential protective mechanisms in these relationships remain underexplored. This longitudinal study investigated mediating role of mindfulness Chinese A sample 1,421 high school students participated this study. The participants were asked...
To explore the chemical constituents of Ecballium elaterium and their cytotoxicity, this study employed multiple chromatographic techniques including normal-phase silica gel, MCI, octadecylsilyl(ODS), Sephadex LH-20 semi-preparative liquid chromatography for compound isolation from its active fraction. A total 12 compounds were obtained, they identified according to analysis a variety spectral data literature comparison as...
To investigate effects of metformin on the regulation proteins white adipose tissue (WAT) and brown (BAT) in obesity explore underlying mechanisms energy metabolism.C57BL/6J mice were fed with normal diet (ND, n = 6) or high-fat (HFD, 12) for 22 weeks. HFD-induced obese treated (MET, 6). After treatment 8 weeks, oral glucose tolerance test (OGTT) hyperinsulinemic-euglycemic clamp performed to evaluate improvement insulin sensitivity. Protein expressions WAT BAT among ND, HFD, MET group...
Bowen's disease is a cutaneous squamous cell carcinoma (CSCC) in situ. If left untreated, BD may progress to invasive CSCC. CSCC one of the most common elderly and advanced, metastasis usually have poor outcomes. However, mechanisms invasion from complicated still unclear.The aim this study was explore biomarkers molecular alterations development process via analyzing proteomics changes tissues CSCC, Bowen healthy skin.A total 7 individuals with (5 for 2 validation), validation) controls...
Background The pathogenesis of vitiligo remains elusive. Emerging evidence suggests that is an immune-mediated disorder, in which a plethora immune cells play pivotal roles. However, the association between circulating and continues to be enigmatic. Materials methods We extracted single nucleotide polymorphisms (SNPs) associated with at genome-wide significance level from BLOOD CELL CONSORTIUM’s study (GWAS) dataset. Summary data for 385,801 cases were obtained large-scale Finnish...
High-fat diet (HFD) leads to the development of obesity accompanied by insulin resistance, which increases risk type 2 diabetes mellitus and cardiovascular disease. Brown adipose tissue (BAT) plays an essential role in energy metabolism, thus it will give us promising treatment targets through elucidating underlying mechanisms BAT obesity. In this study, female C57BL/6J mice were fed HFD or normal (ND) for 22 weeks. Hyperinsulinemic-euglycemic clamp was performed evaluate sensitivity,...
Alveolar macrophages (AMs) are pivotal for maintaining lung immune homeostasis. We demonstrated that deletion of liver kinase b1 (Lkb1) in CD11c+ cells led to greatly reduced AM abundance the due impaired self-renewal AMs but not impeded pre-AM differentiation. Mice with Lkb1-deficient exhibited deteriorated diseases during airway Staphylococcus aureus (S. aureus) infection and allergic inflammation, excessive accumulation neutrophils more severe pathology. Drug-mediated depletion...
• FPZ alleviated hyperglycemia in STZ-induced diabetic mice. increased antioxidant response and protected pancreatic islet against damage. inhibited Atrogin-1 Trim63 expression prevented muscle atrophy. To explore the effects of Chinese raspberry (Fu-Pen-Zi) on diabetes, a polyphenol-enriched extract (FPZ) was prepared. Streptozotocin (STZ)-induced mice were daily administered (30 mg/kg body weight) for 18 days, anti-diabetic evaluated. Compared to STZ alone mice, FPZ-treatment ameliorated...
White adipose tissue (WAT) plays a significant role in energy metabolism and the obesity epidemic. In this study, we sought to (1) profile mouse WAT proteome with advanced 2DLC/MS/MS approach, (2) provide insight into function based on protein functional annotation, (3) predict potentially secreted proteins. A label-free proteomic approach was used identify from female WAT. total of 6,039 proteins were identified, among which 5,160 quantified (spanning magnitude 106) using an intensity-based...
Type 1 diabetes is classified as either autoimmune (type 1A) or idiopathic 1B) diabetes.1 Recently, fulminant type has been identified a new subtype of diabetes.2,3 It characterized by an abrupt onset diabetic ketoacidosis within short period time (4 days on average), complete destruction pancreatic β cells, remarkably elevated plasma glucose level, and near-normal HbA1c level. The patients often have flu-like abdominal symptoms at level exocrine enzymes. Their diabetes-related...
Knowledge about the mouse brown adipose tissue (BAT) proteome can provide a deeper understanding of function mammalian BAT. Herein, comprehensive analysis interscapular BAT from C57BL/6J female mice was conducted by 2DLC and high-resolution mass spectrometry to construct dataset proteins. A total 4949 nonredundant proteins were identified, 4495 quantified using iBAQ method. According values, divided into high-, middle- low-abundance The functions high-abundance mainly related glucose fatty...
Vitiligo is a multifactorial polygenic disorder, characterized by acquired depigmented skin and overlying hair resulting from the destruction of melanocytes. Genome-wide association studies (GWASs) vitiligo have identified approximately 100 genetic variants. However, identification functional genes their regulatory elements remains challenge. To prioritize putative DNAm sites, we performed Summary data-based Mendelian Randomization (SMR) heterogeneity in dependent instruments (HEIDI) test to...
Abstract Background Verrucous epidermal naevi (VEN) are benign skin tumours, considered keratinocytic naevi, that appear at birth or early childhood. VEN may display a range of appearances, depending on patient age. Although the number studies regarding is increasing, exact mechanism still unknown. Objectives The aim this study was to analyse changes in expression protein factors lesions children by TMT labelling‐based quantitative proteomics. Methods A total 8 with (5 for experiment and 3...
Psoriasis is a multifactorial immune-mediated skin disease with strong genetic background. Previous studies reported that psoriasis family history (PFH) and sporadic (SP) have distinct manifestation predisposition. However, the heterogeneity of PFH SP in major histocompatibility complex (MHC) region has not been fully elucidated. To explore variants MHC drive aggregation psoriasis, we included total 8,127 cases 9,906 healthy controls from Han Chinese divided into two subtypes, (n = 1,538)...
Extreme insulin resistance is caused by genetic defects intersecting with the action pathway or receptor antibodies. Insulin autoimmune syndrome (IAS) not considered one of causes extreme resistance.This work aimed to expand current knowledge and propose diagnostic criteria management strategy a novel type resistance.A patient IAS never experienced hypoglycemia but had persistent hyperglycemia treatment 200 U intravenous per day. Immunoreactive (IRI), free insulin, total were measured. The...
<title>Abstract</title> <bold>Background:</bold> Attentional Network Test (ANT), was widely used to evaluate the performance of three attentional networks, i.e., alerting, orienting and executive attention networks. This study aimed<bold> </bold>to explore characteristics functions in HIV-negative patients with early forms NS their association brain magnetic resonance imaging (MRI) abnormalities. <bold>Methods</bold>: 31 without NS, 30 35healthy controls enrolled from September 2020 November...