A5101436289- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Multiple Sclerosis Research Studies
- Radiomics and Machine Learning in Medical Imaging
- Peripheral Neuropathies and Disorders
- Metastasis and carcinoma case studies
- RNA modifications and cancer
- Tracheal and airway disorders
- Brain Metastases and Treatment
- Cancer Research and Treatments
- HER2/EGFR in Cancer Research
- Drug-Induced Hepatotoxicity and Protection
- Dysphagia Assessment and Management
- Immune Response and Inflammation
- Thyroid Cancer Diagnosis and Treatment
- Immune cells in cancer
- Rheumatoid Arthritis Research and Therapies
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Medical Imaging and Pathology Studies
- Neurofibromatosis and Schwannoma Cases
- Cardiac, Anesthesia and Surgical Outcomes
- NF-κB Signaling Pathways
- Tendon Structure and Treatment
- Genetic factors in colorectal cancer
Biogen (United States)
2022-2025
Southwest Medical University
2024
Shanghai Jiao Tong University
2018-2023
Weifang Medical University
2021-2023
Shanghai Chest Hospital
2018-2023
Chongqing Medical University
2022
Shanghai Clinical Research Center
2018
This study aims to give a new perspective the biomarkers in lung adenocarcinoma (LUAD) brain metastasis, pathways involved and potential therapeutics. We performed comprehensive single-cell level transcriptomic analysis on one LUAD patient with circulating tumor cells (CTCs), primary tissue metastatic using scRNA-seq approach identify metastasis related biomarkers. Further were 7 patients validate cancer hallmark. single collected from either or tissues. Pathological functional studies also...
Both acute and chronic tendon injuries are the most frequently occurring musculoskeletal diseases in human veterinary medicine, with a limited repertoire of successful evidenced-based therapeutic strategies. Inflammation has been suggested as key driver for formation scar adhesion tissue following injury, well pathological alternations degenerative tendinopathy. However, prior efforts to completely block this inflammatory process have yet be largely successful. Recent investigations...
To analyze the perioperative indexes of 389 patients with non-small cell lung cancer in single center after robot-assisted thoracoscopic (RATS) lobectomy, and to summarize surgical key points robotic lobectomy.The clinical data stage I who underwent RATS lobectomy from May 2013 December 2016 were retrospectively analyzed. Among them, there 261 females (67.1%) 128 males (32.9%); aged 20-76 years old, a mean age 55.01 years; ASA 106 cases, II 267 cases III 16 cases; BMI 16.87-34.05, averaged...
With widely use of computed tomography (CT) screening, an increasing number early-stage lung cancers appearing as ground glass opacity (GGO) have been detected. Therefore, attempts made to investigate the feasibility segmentectomy instead lobectomy for those patients with GGO. However, two recently released phase III trials failed distinguish between GGO-containing lesions from pure solid nodules in inclusion criteria, and surgical methods did not minimally invasive surgery open thoracotomy....
To report the first and largest series of robotic-assisted mediastinal surgeries performed in a single center by same surgical team mainland China.From May 2009 to June 2017, 167 patients (100 males, 67 females), with mean age 50.2 years (range, 12-78 years), underwent robotic surgery for treatment mass. Data regarding operation time, docking blood loss, conversion rate, morbidity, mortality survival follow-up were collected analyzed.The time 70.01±29.49 10.12±2.77 min. There 56 thymomas, 52...
Besides the two main histologic types of papillary thyroid carcinoma (PTC), classical PTC (CL-PTC) and follicular variant (FV-PTC), several other variants are described. The encapsulated FV-PTC was recently reclassified as noninvasive neoplasm with papillary-like nuclear features (NIFTP) due to its similarities benign lesions. Specific molecular signatures, however, still unavailable. It is well known that improper DNA repair dysfunctional telomeres may cause telomere-related genome...
Background Vagus nerve and recurrent laryngeal (RLN) injury are not rare complications of lung cancer surgery can cause lethal consequences. Until now, no optimal method other than paying greater attention during has been available. Methods Four patients underwent that involved RLN or vagus injury. The left was cut off then reconstructed immediately surgery. Two direct anastomosis, while the remaining two phrenic replacing tension‐relieving anastomosis. Results All were able to speak after...
Objective: Xeroderma Pigmentosum Complementation Group C (XPC) is a protein involving in nucleotide excision repair (NER). XPC also plays an important role the lung cancer occurrence with mechanism remian unclear up to date. Studies showed that increased stemness of cells related recurrence and metastasis cancer. This study aimed analyze correlation stem cell biomarkers expression overall survival (OS) adenocarcinoma patients. Methods: 140 cases clinical tissue samples 48 paired...
Epidermal growth factor receptor (EGFR) mutations and EGFR overexpression have become the key to occurrence of non-small cell lung cancer (NSCLC).EGFR tyrosine-protein kinase inhibitors (EGRR-Tyrosine Kinase Inhibitors, EGFR-TKIs) were used in clinic treat NSCLC by blocking signaling pathway.Due existence rare secondary under drug load, first generation, second third generation TKIs been clinical practice.In addition, mutation abnormal activation downstream molecules or bypass pathways are...
In STRIVE, natalizumab treatment demonstrated effectiveness in clinical, magnetic resonance imaging (MRI), and patient-reported outcomes (PROs) patients with early relapsing–remitting multiple sclerosis (RRMS). This post hoc analysis examined the safety of who self-identified as either Black/African American (AA) or Hispanic/Latino. Clinical, MRI, PROs were assessed for Black/AA subgroup (n = 40) compared non-Hispanic White 158). As a result very small sample size, Hispanic/Latino 18)...
Mucin 1 belongs to the membrane-binding mucoprotein subfamily, which is normally a highly O-glycosylated polymer protein that mainly expressed in epithelial cells and some hematopoietic cells. was overexpressed many cancer tissues compared normal tissue with lower degree of glycosylation. weakly tumor cells, core site exposed, it widely distributed on surface making an important marker. has wide range applications diagnosis, drug targeted delivery, immunodeficiency therapy. Animal studies...
The immunomodulatory effects of disease-modifying therapies for multiple sclerosis might affect the immune response to vaccines severe acute respiratory syndrome coronavirus 2. We analyzed 2-specific antibody and lymphocyte profile before after Ad26.COV2.S (Johnson & Johnson) vaccination in natalizumab-treated patients with sclerosis. There was a 72-fold increase mean anti-severe 2 spike immunoglobulin G levels 4 weeks 137-fold 6 months. Other signals were within normal ranges....
Objective To analyze the perioperative parameters of non-small cell lung cancer patients who underwent robotic assisted lobectomy and summarize surgical experience. Methods Retrospective review was conducted on 389 consecutive robotic-assisted for clinical stage Ⅰ to Ⅲa at Shanghai Tumor Clinical Medical Center, Chest Hospital between May 2013 December 2016. The maximum diameter tumor preoperative chest CT scan was(1.3±0.6)cm; 153 cases were in Ⅰa, 148 Ⅰb, 32 Ⅰc, 6 Ⅱb, 30 Ⅲa; position...
Introduction Lymphopenia is a known adverse event of dimethyl fumarate (DMF) with treatment dis- continuation recommended for patients severe prolonged (≥6 months) lymphopenia. Because the COVID-19 pandemic burden on healthcare systems, we retrospectively examined impact absolute lymphocyte count (ALC) monitoring frequency (every-3-months vs every-6-months) lym- phopenia detection. Methods Samples from enrolled in phase 3 trials (DEFINE/CONFIRM) and extension study (ENDORSE) were analysed...