A5102787602- COVID-19 Clinical Research Studies
- Immune Cell Function and Interaction
- Long-Term Effects of COVID-19
- COVID-19 and healthcare impacts
- HIV-related health complications and treatments
- HIV Research and Treatment
- IL-33, ST2, and ILC Pathways
- Carcinogens and Genotoxicity Assessment
- Sepsis Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
Oslo University Hospital
1999-2024
University of Oxford
2021
University of Oslo
1999-2017
The Research Council of Norway
1999
In-Q-Tel
1999
Objective: To study the progression of HIV infection in relation to immunological and virological variables with emphasis on role CD8+ lymphocytes. Design: Prospective follow-up from October 1991 patients observed for at least 18 months allowing nucleoside analogue monotherapy. Peripheral CD4+ lymphocyte counts, RNA, soluble CD8 were analysed by statistics evaluation serial data, avoiding time points concurrent infections. Setting: Tertiary university clinic. Patients: Forty-nine followed...
IL-33, required for viral clearance by cytotoxic T cells, is generally expressed in vascular endothelial cells healthy human tissues. We discovered that IL-33 expression was stimulated as a response to adenoviral transduction. This dependent on MRE11, sensor of DNA damage can also be activated DNA, and IRF1, transcriptional regulator cellular responses invasion damage. Accordingly, we observed responded phosphorylation ATM CHK2 depletion or inhibition but not ATM, abrogated stimulation. In...