A5041052516- Cell Adhesion Molecules Research
- Angiogenesis and VEGF in Cancer
- Cancer Cells and Metastasis
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Metastasis and carcinoma case studies
- Protease and Inhibitor Mechanisms
- Eosinophilic Esophagitis
- Breast Cancer Treatment Studies
- Viral Infections and Vectors
- Renal cell carcinoma treatment
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Cerebrovascular and Carotid Artery Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Caveolin-1 and cellular processes
- RNA regulation and disease
- TGF-β signaling in diseases
- Influenza Virus Research Studies
- Cancer Diagnosis and Treatment
- COVID-19 Clinical Research Studies
University of Bergen
2018-2023
Uppsala University
2022
Haukeland University Hospital
2022
Karolinska Institutet
2022
Oslo University Hospital
2012-2018
University of Oslo
2012-2018
University of Münster
2018
Max Planck Institute for Molecular Biomedicine
2018
University of Oxford
2018
Medical University of Vienna
2012
Interleukin (IL)-33 is a nuclear protein that released from stressed or damaged cells to act as an alarmin. We investigated the effects of IL-33 on endothelial cells, using prototype IL-1 family member, IL-1β, reference.Human umbilical vein were stimulated with showing highly similar phosphorylation signaling molecules, induction adhesion and transcription profiles. However, intradermally injected elicited significantly less proinflammatory activation when compared IL-1β led us observe...
Endothelial upregulation of adhesion molecules serves to recruit leukocytes inflammatory sites and appears be promoted by NOTCH1; however, current models based on interactions between active NOTCH1 NF-κB components cannot explain the transcriptional selectivity exerted in this context.Observing that Cre/Lox-induced conditional mutations endothelial Notch modulated inflammation murine contact hypersensitivity, we found IL (interleukin)-1β stimulation induced rapid recruitment RELA (v-rel...
Abstract Cancer‐associated fibroblasts are essential modifiers of the tumor microenvironment. The collagen‐binding integrin α11β1 has been proposed to be upregulated in a pro‐tumorigenic subtype cancer‐associated fibroblasts. Here, we analyzed expression and clinical relevance large breast cancer series using novel antibody against human α11 chain. Several monoclonal antibodies subunit were tested for use on formalin‐fixed paraffin‐embedded tissues, Ab 210F4B6A4 was eventually selected...
Angiogenesis is crucial for tumor growth and one of the hallmarks cancer. In this study, we analyzed microvessel density, vessel median size, perivascular a-SMA expression as prognostic biomarkers in breast cancer.Dual IHC staining was performed where alpha-SMA antibodies were used together with against endothelial cell marker CD34. Digital images stainings to extract quantitative data on status.The analyses discovery cohort (n = 108) revealed a statistically significant relationship between...
Predictive biomarkers are needed to aid the individualization of radiotherapy (RT) in breast cancer. Cancer-associated fibroblasts have been implicated tumor radioresistance and can be identified by platelet-derived growth factor receptor-beta (PDGFRb). This study aims analyze how PDGFRb expression affects RT benefit a large randomized trial.PDGFRb was assessed immunohistochemistry on tissue microarrays from 989 tumors SweBCG91RT trial, which enrolled lymph node-negative, stage I/IIA cancer...
Clear cell renal carcinoma (ccRCC) is the most common type of carcinoma, and anti-angiogenic treatment currently first line therapy for metastatic ccRCC (mccRCC). Response rates duration response show considerable variation, adverse events have a major influence on patient quality life. The need predictive biomarkers to select responders receptor tyrosine kinase inhibitors upfront urgent. We investigated value immunohistochemical associated with angiogenesis systemic inflammation in mccRCC....
IL-33, required for viral clearance by cytotoxic T cells, is generally expressed in vascular endothelial cells healthy human tissues. We discovered that IL-33 expression was stimulated as a response to adenoviral transduction. This dependent on MRE11, sensor of DNA damage can also be activated DNA, and IRF1, transcriptional regulator cellular responses invasion damage. Accordingly, we observed responded phosphorylation ATM CHK2 depletion or inhibition but not ATM, abrogated stimulation. In...
Abstract Background: Although preclinical studies have indicated that stroma cells can modulate the radiosensitivity of tumor cells, non-leukocytic not yet been explored as potential predictive markers for radiotherapy (RT) through systematic analyses clinical samples. Platelet-derived growth factor receptor beta (PDGFRb) is a key regulator fibroblasts, pericytes and smooth muscle cells. A high expression PDGFRb in tumor-associated has previously associated with worse recurrence free breast...
Abstract Background Angiogenesis is crucial for tumor growth and one of the hallmarks cancer. In this study, we analyzed microvessel density, vessel median size, perivascular a-SMA expression as prognostic biomarkers in breast Methods A set dual IHC staining was performed where alpha-SMA antibodies were used together with against endothelial cell marker CD34. Digital images stainings to extract quantitative data on size status. Results The analyses discovery cohort (n = 108) revealed a...
Abstract Angiogenesis is crucial for tumor growth and one of the hallmarks cancer. In this study, we analyzed microvessel density, vessel median size, perivascular a-SMA expression as prognostic biomarkers in breast Dual IHC staining was performed where alpha-SMA antibodies were used together with against endothelial cell marker CD34. Digital images stainings to extract quantitative data on size status. The analyses discovery cohort (n = 108) revealed a statistically significant relationship...