A5079039649- Effects and risks of endocrine disrupting chemicals
- Per- and polyfluoroalkyl substances research
- Birth, Development, and Health
- Influenza Virus Research Studies
- Adipose Tissue and Metabolism
- Viral Infections and Outbreaks Research
- Respiratory viral infections research
- Diabetes and associated disorders
- Microplastics and Plastic Pollution
- SARS-CoV-2 and COVID-19 Research
- Pneumonia and Respiratory Infections
- Nuclear and radioactivity studies
- SARS-CoV-2 detection and testing
- IL-33, ST2, and ILC Pathways
- Vitamin D Research Studies
- Agricultural safety and regulations
- Food Allergy and Anaphylaxis Research
- Substance Abuse Treatment and Outcomes
- Gestational Diabetes Research and Management
- Marine Bivalve and Aquaculture Studies
- Liver Diseases and Immunity
- Criminal Justice and Corrections Analysis
- Electrolyte and hormonal disorders
- Hepatitis Viruses Studies and Epidemiology
- Vitamin C and Antioxidants Research
Norwegian Institute of Public Health
2013-2024
University of Oslo
2012-2022
Norwegian University of Life Sciences
2022
Oslo University Hospital
2012-2020
Cosmetics Europe
2013
Medical University of Vienna
2012
Bærum Sykehus
2012
Diabetes mellitus type 1 is an autoimmune disease with a genetic predisposition that triggered by environmental factors during early life. Epidemiological studies show bisphenol A (BPA), endocrine disruptor, has been detected in about 90% of all analyzed human urine samples. In this study, BPA was found to increase the severity insulitis and incidence diabetes female non obese diabetic (NOD) mice offspring after transmaternal exposure through dams' drinking water (0, 0.1, 1, 10mg/l). Both...
Exposure to the endocrine disruptor (ED) bisphenol A (BPA) used in polycarbonate plastic and epoxy resins appears ubiquitous since BPA can be found over 90% of analyzed urine samples from all age groups. There is a parallel occurrence increased prevalence type 1 diabetes mellitus (T1DM) an exposure EDs last decades. T1DM caused by insulin deficiency due autoimmune destruction producing pancreatic beta cells has been suggested induced various environmental factors acting together with genetic...
Type 1 diabetes mellitus (T1DM) is an autoimmune destruction of insulin producing pancreatic beta-cells due to a genetic predisposition and can be triggered by environmental factors. We have previously shown that bisphenol A (BPA) accelerates the spontaneous development in non-obese diabetic (NOD) mice. Here, we hypothesized oral exposure mixture endocrine disruptors BPA phthalates, relevant for human exposure, would accelerate compared alone. NOD mice were exposed (1 mg/l), phthalates (DEHP...
In the last decade, increasing incidence of type 1 diabetes (T1D) stabilized in Finland, a phenomenon that coincides with tighter regulation perfluoroalkyl substances (PFAS). Here, we quantified PFAS to examine their effects, during pregnancy, on lipid and immune-related markers T1D risk children. mother-infant cohort (264 dyads), high exposure pregnancy associated decreased cord serum phospholipids progression T1D-associated islet autoantibodies offspring. This PFAS-lipid association...
We studied the secondary attack rate (SAR), risk factors, and precautionary practices of household transmission in a prospective, longitudinal study. further compared between Alpha (B.1.1.7) variant non-Variant Concern (non-VOC) viruses. From May 2020 throughout April 2021, we recruited 70 confirmed COVID-19 cases with 146 contacts. Participants donated biological samples eight times over 6 weeks answered questionnaires. SARS-CoV-2 infection was detected by real-time RT-PCR. Whole genome...
Interleukin (IL)-33 is a nuclear protein that released from stressed or damaged cells to act as an alarmin. We investigated the effects of IL-33 on endothelial cells, using prototype IL-1 family member, IL-1β, reference.Human umbilical vein were stimulated with showing highly similar phosphorylation signaling molecules, induction adhesion and transcription profiles. However, intradermally injected elicited significantly less proinflammatory activation when compared IL-1β led us observe...
Abstract In mice, prenatal exposure to low doses of bisphenol A has been shown affect neurogenesis and neuronal migration in cortex, resulting disturbance both positioning the network formation between thalamus cortex offspring brain. present study we investigated whether disturbs neurodevelopment cerebellum. Two different model systems were used; from two strains mice mothers receiving drinking water before mating, during gestation lactation, chicken embryos exposed (in egg) on embryonic...
Perfluoralkylated substances (PFAS) are classified as persistent, bioaccumulative and toxic widespread environmental contaminants. Humans exposed through food, drinking water air. We have previously reported that bisphenol A accelerates spontaneous diabetes development in non-obese diabetic (NOD) mice observed the present study perfluoroundecanoic acid, PFUnDA, increased insulitis development, a prerequisite for NOD mice. to PFUnDA (3, 30 300 μg/l) at mating, during gestation lactation until...
Bisphenol A (BPA) and phthalates are common environmental contaminants that have been proposed to influence incidence development of types 1 2 diabetes. Thus, effects BPA three phthalate metabolites (monoisobutyl (MiBP), mono-n-butyl (MnBP), mono-(2-ethylhexyl) (MEHP)) were studied in the pancreatic β-cell line INS-1E, after 2-72 h exposure 5-500 μM. Three endpoints relevant accelerated or diabetes investigated: viability, glucose-induced insulin secretion, susceptibility cytokine-induced...
Exposure to Per- and polyfluoroalkyl substances (PFAS) has been linked multiple undesirable health outcomes across a full lifespan, both in animal models as well human epidemiological studies. Immunosuppressive effects of PFAS have reported, including increased risk infections suppressed vaccination responses early childhood, association with immunotoxicity diabetes. On mechanistic level, exposure metabolic disturbances, particularly lipid metabolism, but the underlying mechanisms are poorly...
In genetically modified (GM) crops there is a risk that the inserted genes may introduce new allergens and/or adjuvants into food and feed chain. The MON810 maize, expressing insecticidal Cry1Ab toxin, grown in many countries worldwide. animal models, intranasal intraperitoneal immunisations with purified proteins have induced immune responses, feeding trials Cry1Ab-containing revealed some altered responses. Previous investigations primarily measured antibody responses to protein, while of...
The 2009 “swine flu” pandemic outbreak demonstrated the limiting capacity for egg-based vaccines with respect to global vaccine supply within a timely fashion. New platforms that efficiently can quench influenza emergences are urgently needed. Since 2009, there has been profound development of new platform technologies prophylactic use in population, including DNA vaccines. These particularly well suited responses as format is temperature stable and production process cheap rapid. Here, we...
Abstract Introduction Autoimmune disorders such as type 1 diabetes (T1D) are believed to be caused by the interplay between several genetic and environmental factors. Elucidation of role factors in metabolic immune dysfunction leading autoimmune disease is not yet well characterized. Objectives Here we investigated impact exposure a mixture persistent organic pollutants (POPs) on metabolome non-obese diabetic (NOD) mice, an experimental model T1D. The contained organochlorides,...
Preschool children in Addis Ababa, Ethiopia, are highly exposed to influenza viruses. Factors related infections, nutrition, and environmental conditions that might explain the burden of among these were investigated. Ninety-five preschool children, 48 girls 47 boys, followed clinically for 12 months. Illness immune responses influenza; three other respiratory viruses; five airway pathogenic bacteria; levels vitamins D, A, B12 assessed. Most had antibodies numerous viral bacterial agents at...
Abstract In the last decade, increasing incidence of type 1 diabetes (T1D) stabilized in Finland, a phenomenon that coincides with tighter regulation perfluoroalkyl substances (PFAS). Here, we quantified PFAS to examine their effects, during pregnancy, on lipid and immune-related markers T1D risk children. mother-infant cohort (264 dyads), high exposure pregnancy associated decreased cord serum phospholipids progression T1D-associated islet autoantibodies offspring. This PFAS-lipid...
Exposure to chlorinated (Cl), brominated (Br) and perfluoroalkyl acid (PFAA) persistent organic pollutants (POPs) is associated with immunotoxicity other adverse effects in humans animals. Previous studies on POPs have mainly focused single chemicals, while complex mixtures are limited. Using DCF luminol assays we examined ROS generation isolated human neutrophils, monocytes lymphocytes, after vitro exposure a total mixture sub-mixtures of 29 compounds (Cl, Br, PFAA). The were based...
Seasonal influenza causes substantial numbers of hospitalizations annually. We have characterized the clinical picture and treatment practice in hospitalized adult patients assessed whether risk scores on admission or type were associated with severe outcomes.Clinical characteristics (CRB65, CRB, SIRS quick Sequential Organ Failure Assessment [qSOFA]), outcomes (defined as: stay intensive care unit (ICU), receiving oxygen supplementation staying ≥5 days hospital), recorded at Oslo University...