A5011839955- Effects and risks of endocrine disrupting chemicals
- Meta-analysis and systematic reviews
- Neuroscience and Neuropharmacology Research
- Nuclear Receptors and Signaling
- Health Systems, Economic Evaluations, Quality of Life
- Animal testing and alternatives
- Coffee research and impacts
- Neuroinflammation and Neurodegeneration Mechanisms
- Macrophage Migration Inhibitory Factor
- Pesticide Residue Analysis and Safety
- Anesthesia and Neurotoxicity Research
- Potato Plant Research
- Microplastics and Plastic Pollution
- Toxic Organic Pollutants Impact
- Retinoids in leukemia and cellular processes
- Statistical Methods in Clinical Trials
- Genomics, phytochemicals, and oxidative stress
- Stress Responses and Cortisol
- Agricultural safety and regulations
- Coenzyme Q10 studies and effects
- Vitamin C and Antioxidants Research
- Research Data Management Practices
- Consumer Attitudes and Food Labeling
- Skin Protection and Aging
- Obesity and Health Practices
Norwegian Institute of Public Health
2023-2025
Norwegian Food Safety Authority
2018-2022
University of Oslo
2006-2016
Nordic Institute of Dental Materials
2012-2014
UiT The Arctic University of Norway
1987
Abstract In mice, prenatal exposure to low doses of bisphenol A has been shown affect neurogenesis and neuronal migration in cortex, resulting disturbance both positioning the network formation between thalamus cortex offspring brain. present study we investigated whether disturbs neurodevelopment cerebellum. Two different model systems were used; from two strains mice mothers receiving drinking water before mating, during gestation lactation, chicken embryos exposed (in egg) on embryonic...
Organising workshops that successfully address complex research problems is a challenge, especially when the involves interest-holders with diverse roles and expertise potentially conflicting values viewpoints. In this article, we describe reflect on approach took to organising CHANGE workshop, held in Oslo June 2024. 3-year project involving collecting, analysing, developing cross-sector consensus challenging topic. The approaches which include fundamental aspects of interest-holder...
This protocol describes the design and development of a tool for evaluation internal validity in vitro studies, which is needed to include data as evidence systematic reviews chemical risk assessments. The will be designed specifically applied cell culture including, but not restricted to, studies meeting new approach methodology (NAM) definition. called INVITES-IN (IN VITro Experimental Studies INternal validity).In this protocol, three four that performed create release version are...
Antioxidants (radical scavengers and 15-lipoxygenase inhibitors) in semipolar extracts of root bark from the Malian medicinal plant Lannea velutina have been investigated. A series proanthocyanidins with degree polymerization 2 to more than 12 have isolated, addition monomeric substance, catechin. The major constituents a ten or more. Most structures are proposed be derived common biosynthetic route which catechin is introduced as terminal unit epicatechin units extenders. Catechin, dimeric,...
The developing cerebellum is vulnerable to effects of glucocorticoids and cerebellar dysfunction associated with neurodevelopmental disorders (e.g. autism). Transcription factor PAX 6 matrix metalloproteinase‐9 ( MMP ‐9) are critical for normal development highly expressed in migrating neurones. Alterations ‐9 altered development. In the present study, we characterised growth rate cortical layers, further investigated how levels ‐9, as well glucocorticoid receptor GR ) proliferating cell...
4-Methylimidazole (4MeI) is a tremorogenic and convulsive agent of concern both in human veterinary toxicology. The vitro effects 4MeI (5 μM–20 mM) on cerebral glutamate decarboxylase (GAD) activity (in concentrations up to 50 binding [3H]GABA GABA receptors were tested brain tissue from B6D2 mice. 1-methylimidazole (1MeI), 2-methylimidazole (2MeI), 4-methylhydroxy-imidazole (4MeOHI), imidazole-4-acetic acid (4AcI) (all 5–20 imidazole (20 GAD also tested. In addition, the effect lethal dose...
Chemical contaminants are present in all foods. Data on the occurrence of foods that often consumed or contain high contaminant concentrations critical for estimation exposure and evaluation potential negative health effects. Due to limited resources monitoring other chemical substances foods, methods prioritisation needed. We have developed a straightforward semi-quantitative method rank as part risk-based food control. The is based considerations toxicity, level including both dietary...
During the last decades it has been shown that estrogen may have neuroprotective functions in CNS. However, we previously reported pretreatment with estradiol abolishes its protection of cultured cerebellar granule neurons from glutamate-induced cell death due to down-regulation endogenous glutathione. 17α-Estradiol is considered a hormonally inactive isomer 17β-estradiol still containing antioxidant potential. Here, demonstrate 17α-estradiol enhanced serum deprivation-induced rat...
The focus on implementation of systematic review (SR) principles in chemical risk assessments (CRAs) is growing as it has the potential to advance rigour and transparency CRAs. However, SR CRA communities use their own specific terminologies. Understanding meaning core terms where they overlap critical for application methods Moreover, will increase possibility cross-sectorial collaboration, avoid misunderstandings, improve communication among assessors, researchers, policy makers. We...
Risk and risk-benefit assessments of food are complex exercises, in which access to use several disconnected individual stand-alone databases is required obtain hazard exposure information. Data obtained from such ideally should be line with the FAIR principles, i.e. data must Findable, Accessible, Interoperable Reusable. However, often cases encountered when one or more these principles not followed. In this project, we set out assess if existing commonly used risk assessment principles. We...