A5074349580- Neurotransmitter Receptor Influence on Behavior
- Cannabis and Cannabinoid Research
- Neuroscience and Neuropharmacology Research
- Nonlinear Partial Differential Equations
- Hormonal and reproductive studies
- Growth Hormone and Insulin-like Growth Factors
- Nonlinear Differential Equations Analysis
- Receptor Mechanisms and Signaling
- Neuroscience of respiration and sleep
- Nicotinic Acetylcholine Receptors Study
- Pancreatic function and diabetes
- Cyclopropane Reaction Mechanisms
- Stress Responses and Cortisol
- Regulation of Appetite and Obesity
- Adrenal Hormones and Disorders
- Sleep and Wakefulness Research
- Advanced Mathematical Modeling in Engineering
- Diet and metabolism studies
- Advanced Banach Space Theory
- Estrogen and related hormone effects
- Thyroid Disorders and Treatments
- Advanced Topics in Algebra
- Neuropeptides and Animal Physiology
- Prenatal Substance Exposure Effects
- Catalytic C–H Functionalization Methods
Hospital Universitario 12 De Octubre
2023-2025
Universidad Complutense de Madrid
2001-2025
University of Minho
2022
Universidad de Los Andes
2022
Universidade da Coruña
2022
Applied Energetics (United States)
2021
Universidade de Santiago de Compostela
2010-2020
Complejo Hospitalario de Salamanca
2018
University of Almería
1998-2016
Universidad de Granada
2012-2016
Corticotropin-releasing factor (CRF) has been implicated in the mediation of stress-like and negative affective consequences withdrawal from drugs abuse, such as alcohol, cocaine, opiates. This study sought to determine whether brain CRF systems also have a role cannabinoid dependence. Rats were treated daily for 2 weeks with potent synthetic HU-210. Withdrawal, induced by antagonist SR 141716A, was accompanied marked elevation extracellular concentration distinct pattern Fos activation...
Abstract: This study was designed to determine the possible role of brain glucagon‐like peptide‐1 (GLP‐1) receptors in feeding behavior. In situ hybridization showed colocalization mRNAs for GLP‐1 receptors, glucokinase, and GLUT‐2 third ventricle wall adjacent arcuate nucleus, median eminence, supraoptic nucleus. These areas are considered contain glucose‐sensitive neurons mediating Because GLUT‐2, glucokinase proteins involved multistep process glucose sensing pancreatic β cells, specific...
We characterized the pharmacological properties of anandamide transport inhibitor N-(4-hydroxyphenyl)-arachidonamide (AM404) in rats and investigated effects this drug on behavioral responses associated with activation dopamine D(2) family receptors. Rat brain slices accumulated [(3)H]anandamide via a high-affinity mechanism that was blocked by AM404. When administered alone vivo, AM404 caused mild slow-developing hypokinesia significant 60 min after intracerebroventricular injection...
The present study evaluated the modulatory role of central corticotropin-releasing factor (CRF) systems in mediation effects acute exposure to brain cannabinoid receptor agonist HU-210 [3-(1,1-dimethylheptyl)-(-)-11-hydroxy-delta 8-tetrahydrocannabinol] on defensive withdrawal behavior male rats. apparatus used for test consisted a small chamber, set one side one-square meter open field. actions potent CRF antagonist [D-Phe12,Nle21,38,C alpha MeLeu37]CRF (D-Phe CRF12-41) were examined under...
Article AbstractBackground: The onset of diabetes and impaired glucose metabolism among schizophrenic patients has been the topic numerous recently published articles, with research implicating weight gain, use antipsychotic medication, history mellitus in family members, diagnosis schizophrenia itself as risk factors. Therefore, it was aim this study to determine parameters noncompliant unmedicated (antipsychotic-free) first-episode antipsychotic-naive investigate whether there is a...
Leptin secretion is influenced by many factors and the GH/IGF axis plays an important role in regulation of body composition, but physiological interactions between leptin IGF-I system remain unknown. In this study we investigated relationship leptin, system, sex, age, anthropometric composition variables a group healthy adults randomly selected.A cross-sectional study.The included 268 subjects, representative whole population city L'Hospitalet de Llobregat sex age distribution: 134 men aged...
The endogenous cannabinoid acylethanolamide AEA (arachidonoylethanolamide; also known as anandamide) participates in the neuroadaptations associated with chronic ethanol exposure. However, no studies have described acute actions of on production and degradation. In present study, we investigated time course effects intraperitoneal administration (4 g/kg body mass) levels central peripheral tissues. Acute decreased cerebellum, hippocampus nucleus accumbens ventral striatum, well plasma...
Now with nickel: [3C+2C+2C] cycloadditions involving non-activated alkylidenecyclopropanes provide a practical entry to variety of interesting 6,7-fused bicyclic systems (see scheme; cod=1,5-cyclooctadiene). DFT calculations, combined experimental data, suggest that the catalytic cycle involves initial formation 1-alkylidenenickelacyclobutane intermediates, such as 1.
Serotonin 5-HT2A and 5-HT4 binding parameters their second messengers 1,4,5-inositol triphosphate (IP<sub>3</sub>) cyclic adenosyl monophosphate (cAMP) were studied in the frontal cortex, hippocampus, caudate nucleus amygdala of 19 control subjects antidepressant-free, violent suicide victims. A significantly higher number receptors messenger cAMP concentrations found cortex depressed victims as compared with group. Furthermore, increased sites IP<sub>3</sub> noted...
Abstract The endocannabinoid system mediates in the pharmacological actions of ethanol and genetic studies link signaling to alcoholism. Drugs activating cannabinoid CB1 receptors have been found promote alcohol consumption but their effects on self‐administration are less clear because interference with motor performance. To avoid this problem, a novel approach study contribution alcoholism may be use drugs that locally amplify endogenous cannabinoids. In present we addressed model by...