A5013043572- Cholangiocarcinoma and Gallbladder Cancer Studies
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Pediatric Hepatobiliary Diseases and Treatments
- MicroRNA in disease regulation
- Cancer-related Molecular Pathways
- Molecular Biology Techniques and Applications
- Cervical Cancer and HPV Research
- Peptidase Inhibition and Analysis
- Cancer-related gene regulation
- Drug Transport and Resistance Mechanisms
- Cancer-related molecular mechanisms research
- Silk-based biomaterials and applications
- Tannin, Tannase and Anticancer Activities
- Osteoarthritis Treatment and Mechanisms
- Spectroscopy Techniques in Biomedical and Chemical Research
- Genetic factors in colorectal cancer
- Bacteriophages and microbial interactions
- Cancer Mechanisms and Therapy
- Biosensors and Analytical Detection
- Malaria Research and Control
- Advanced biosensing and bioanalysis techniques
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Periodontal Regeneration and Treatments
Khon Kaen University
2015-2025
Centre for Research and Development
2010-2016
Medical Diagnostic Laboratories (United States)
2010-2016
Faculty (United Kingdom)
2015
Imperial College London
2013
QIMR Berghofer Medical Research Institute
1990-1992
Mahidol University
1987
Cervical cancer (CxCa) is the most common in women and a prominent cause of mortality worldwide. The primary CxCa human papillomavirus (HPV). Radiation therapy chemotherapy have been used as standard treatments, but they undesirable side effects for patients. It was reported that gallic acid has antioxidant, antimicrobial, anticancer activities. Gold nanoparticles are currently being medicine biosensors drug delivery agents. This study aimed to develop agent using gold conjugated with acid....
Summary The nucleotide sequence of cosmid B1790, carrying the Rif‐Str regions Mycobacterium leprae chromosome, has been determined. Twelve open reading frames were identified in 36716bp sequence, representing 40% coding capacity. Five ribosomal proteins, two elongation factors and β β'subunits RNA polymerase have characterized novel genes found. One these encodes a member so‐called ABC family ATP‐binding proteins while other appears to encode an enzyme involved repairing genomic lesions...
Foodborne pathogens, including Plesiomonas shigelloides and Shigella flexneri B, are the major cause of diarrheal endemics worldwide. Antibiotic drug resistance is increasing. Therefore, bioactive compounds with antibacterial activity, such as gallic acid (GA), needed. Gold nanoparticles (AuNPs) used delivery agents. This study aimed to conjugate characterize AuNP-GA evaluate activity. AuNP was conjugated GA, core-shell structures were characterized by small-angle X-ray scattering...
Cholangiocarcinoma (CCA) is a fatal cancer of the bile duct epithelial cell lining. The misdiagnosis CCA and other biliary diseases may occur due to similarity clinical manifestations blood tests resulting in inappropriate or delayed treatment. Thus, an accurate less-invasive method for differentiating from inevitable. We quantified methylation OPCML, HOXA9, HOXD9 serum cell-free DNA (cfDNA) patients using methylation-sensitive high-resolution melting (MS-HRM). Their potency as differential...
Genetic changes have been widely reported in association with cholangiocarcinoma (CCA), while epigenetic are poorly characterised. We aimed to further evaluate CpG-island hypermethylation CCA at candidate loci, which may potential as diagnostic or prognostic biomarkers.We analysed methylation of 26 CpG-islands 102 liver fluke related-CCA and 29 adjacent normal samples using methylation-specific PCR (MSP). Methylation interest loci was confirmed pyrosequencing and/or combined bisulfite...
All p53 family members are expressed in several isoforms through alternative promoters and splicing. However, the significance of these is not yet well understood cholangiocarcinoma (CCA). In this study, we investigated expression p53, p63, p73 their at mRNA protein levels CCA. The overexpression ∆133p53 was observed CCA cell lines clinical specimens. Moreover, high ∆133p53/TAp53 correlated with short overall survival (p<0.001). Defective including mutant ∆Np53, associated poor prognosis...
Adult chondrocytes are surrounded by a protein- and glycosaminoglycan-rich extracellular matrix subjected to dynamic mechanical compression during daily activities. The stimuli play an important role in chondrocyte biosynthesis homeostasis. In this study, we aimed develop scaffold compressive loading conditions that mimic the native cartilage micro-environment enable enhanced chondrogenesis for tissue engineering applications. Towards aim, fabricated porous scaffolds based on silk fibroin...
Cholangiocarcinoma (CCA) is a rare malignancy of the biliary tract with extremely poor clinical outcomes due to lack effective therapies improve disease management. The emerging green synthesis gold nanoparticles (AuNPs) has extensively provided their use in biomedical applications. In this study, we developed AuNPs via reducing salts apigenin (4',5,7-trihydroxyflavone). synthesized apigenin-conjugated (api-AuNPs) were physicochemically characterized by various techniques before evaluation...
Abstract A limited self‐healing ability of injured articular cartilage results in osteoarthritis and a joint dysfunction afterward. Cartilage tissue engineering is promising approach to increase the treatment efficiency. Moreover, host response implanted biomaterial has been increasingly concerned. Thus, this study aimed establish three‐dimensional (3D) scaffold that could support reduce inflammatory. The various ratios silk fibroin (SF), gelatin (G), chondroitin sulfate (C), hyaluronic acid...
AIM:To investigate trefoil factor (TFF ) gene copy number, mRNA and protein expression as potential biomarkers in cholangiocarcinoma (CCA).METHODS: TFF levels, number were determined respectively by quantitative reverse transcription polymerase chain reaction (PCR), PCR immunohistochemistry bile duct epithelium biopsies collected from individuals with CCA, precancerous dysplasia disease-free controls.The functional impact of recombinant human (rh)TFF2 peptide treatment on proliferation...
Cervical cancer (CxCa) is a major health problem globally and associated with the presence of human papillomavirus infection. Cisplatin (CDDP) platinum-based chemotherapeutic agent. Owing to its side effects drug-resistance, novel anticancer agents lower toxicity, including caffeic acid (CFC), are interest. However, CDDP CFC in combination are, best our knowledge, uninvestigated. The present study investigated effectiveness mechanism action on four cervical cell lines, which were compared...
Cholangiocarcinoma (CCA) is a rare and highly aggressive cancer of the biliary tract, associated with poor clinical outcomes due to late diagnosis, extensive metastasis, drug resistance, limited treatment options. Apigenin, natural flavonoid, has been found exhibit anticancer properties in several types human cells. Therefore, apigenin may be relevant developing chemotherapeutic agents for treatment. In this study, we examined effects on cell viability, cycle distribution, apoptosis,...
A major limiting factor in stem cell therapy is the accurate identification of differentiation state cells destined for transplantation. This study aimed to evaluate potential synchrotron radiation Fourier transform infrared (SR-FTIR) microspectroscopy as a novel technique probe human mesenchymal (hMSCs) chondrocytes over period 7, 14 and 21 days induction. The chondrogenic markers were determined using reverse transcription polymerase chain reaction, histology immunohistochemistry. changes...
Extracts of Caesalpinia mimosoides Lamk has been reported to possess anticancer effects, but the active ingredients and anti-cancer mechanisms are still unknown.The effects a C extract on cell proliferation apoptosis induction in human cervical carcinoma lines, namely HeLa, SiHa, C33A, as well normal Vero cells, were investigated.Treatment with 5 fractions (F17-F21) methanol extracts inhibited viability dose- time- dependent manner. Neutral red assays indicated that treatment F21...
Cholangiocarcinoma (CCA) is a malignancy of the bile duct epithelium which caused by liver fluke infection. The clinical symptoms CCA were revealed as disease progresses to advanced stage. Thus, specific diagnostic biomarkers are important for this fatal disease. We applied methylation-sensitive high-resolution melting (MS-HRM) quantify DNA methylation levels opioid binding protein/cell adhesion molecule-like gene (OPCML) and Secreted frizzled-related protein 1 (SFRP1) in 73 primary 10...