A5085531650- Cerebrovascular and Carotid Artery Diseases
- Phagocytosis and Immune Regulation
- Intracranial Aneurysms: Treatment and Complications
- Moyamoya disease diagnosis and treatment
- Glioma Diagnosis and Treatment
- Renal and Vascular Pathologies
- Urticaria and Related Conditions
- Immunotherapy and Immune Responses
- Vascular Malformations Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Neurological Complications and Syndromes
- Drug-Induced Adverse Reactions
- Asthma and respiratory diseases
- Meta-analysis and systematic reviews
- Health Systems, Economic Evaluations, Quality of Life
- Cancer Cells and Metastasis
- Immune cells in cancer
- Congenital Heart Disease Studies
- Statistical Methods in Clinical Trials
- Spinal Dysraphism and Malformations
- Chronic Kidney Disease and Diabetes
- Food Allergy and Anaphylaxis Research
- Head and Neck Surgical Oncology
- Nanoplatforms for cancer theranostics
- Cerebral Venous Sinus Thrombosis
New York University
2018-2023
NYU Langone Health
2021-2023
Bellevue Hospital Center
2022
Stanford Medicine
2022
Stanford University
2015-2019
Lucile Packard Children's Hospital
2017-2019
Protein Metrics (United States)
2017
California Institute for Regenerative Medicine
2017
Universidad de Navarra
2004
Mexican Social Security Institute
2001
Anti-CD47 antibody is effective for treating malignant pediatric brain tumors without detectable toxicity in patient-derived xenograft models.
Summary Background Hypersensitivity reactions to non‐steroidal anti‐inflammatory drugs (NSAIDs), manifested by cutaneous symptoms and/or airway manifestations represent 20–25% of all hypersensitivity drugs. Today, it is still claimed that no in vitro diagnostic tests exist for condition and the only way confirm diagnosis a provocation challenge. Objective The objective this study was assess whether NSAIDs may provoke blood basophil activation such patients, as detected flowcytometric...
Medulloblastoma is the most common malignant brain tumor of childhood. Group 3 medulloblastoma, aggressive molecular subtype, frequently disseminates through leptomeningeal cerebral spinal fluid (CSF) spaces in and cord. The mechanism dissemination CSF remains poorly understood, pathways involved medulloblastoma metastasis self-renewal are largely unknown. Here we show that NOTCH1 signaling pathway regulates both initiation medulloblastoma. We identify a which activates BMI1 activation...
Irradiation and temozolomide (TMZ) chemotherapy are the current standard treatments for glioblastoma multiforme (GBM), but they associated with toxicity limited efficacy. Recently, these therapies have been used to enhance immunotherapy against GBM. Immunotherapy using anti-CD47 (immune checkpoint inhibitor) treatment has shown promise in treating multiple tumor types, including The goal of this work was test whether irradiation or TMZ could Our results showed that each significantly...
OBJECTIVE The carotid web (CW) is an underrecognized source of cryptogenic, embolic stroke in patients younger than 55 years age, with up to 37% these found have CW on angiography. Currently, there are little data detailing the best treatment practices reduce risk recurrent patients. authors describe their institutional surgical experience treated via endarterectomy (CEA) for a symptomatic internal artery web. METHODS A retrospective, observational cohort study was performed including all...
OBJECTIVE The post-bypass stroke risk factors and long-term outcomes of moyamoya patients are not well documented. Therefore, the authors studied 30-day risks patients’ physical, functional, social well-being. METHODS This was a single-institution combined disease (MMD) database interrogation questionnaire study. From 1991 to 2014, 1250 revascularization procedures (1118 direct bypasses, 132 indirect bypasses) were performed in 769 patients. Completed questionnaires received from available...
OBJECT Metastatic disease to the craniovertebral junction (CVJ) is rare but presents unique management challenges. To date, studies on using stereotactic radiosurgery (SRS) for CVJ metastases have been limited case reports and small series. The aim of this analysis was evaluate utility SRS in these secondary lesions. METHODS Clinical radiological information from charts 25 patients with metastatic who were treated between 2005 2013 at Stanford CyberKnife Center retrospectively reviewed....
Revascularization surgery is a safe and effective surgical treatment for symptomatic moyamoya disease (MMD) has been shown to reduce the frequency of future ischemic events improve quality life in affected patients. The authors sought investigate occurrence acute perioperative occlusion contralateral internal carotid artery (ICA) with stroke following revascularization surgery, rare complication that not previously reported.
BACKGROUND: The new sonolucent cranioplasty implant (clear polymethyl methacrylate, PMMA) adds functionality besides surgical reconstruction. One possible application uses the transcranioplasty ultrasound (TCUS) technique after PMMA to assess graft patency of extracranial-intracranial (EC-IC) bypass procedures. OBJECTIVE: To report our early multicenter experience. METHODS: This is a analysis consecutive EC-IC patients from 5 US centers (2019-2022) with closure postbypass using implant....
<i>Background/Aims:</i> During the first 10 years, two thirds of patients with type 2 diabetes mellitus (DM) have microalbuminuria (MA). Functional renal reserve (FRR) and its relationship proteinuria metabolic control are unknown at early phases disease. We investigated frequency MA in recently diagnosed DM patients, association FRR. <i>Methods:</i> studied 181 less than 6 months since diagnosis. Renal volume, MA, glomerular filtration rate (GFR) plasma flow (ERPF)...
The presence, characteristics, and potential clinical relevance of neural progenitor populations within the placodes myelomeningocele patients remain to be studied. Neural stem cells are known reside adjacent ependyma-lined surfaces along central nervous system axis.Given such neuroanatomic correlation regenerative capacity in fetal development, we assessed myelomeningocele-derived placode tissue as a potentially novel source cells.Nonfunctional was harvested from infants during surgical...
INTRODUCTION: DIPG is the most common malignant brainstem tumor in children. The resistance of to standard treatments along with inoperability this because anatomical location leave patients dismal prognosis. Multiple studies revealed that have only a few months survival after detection cranio-spinal metastasis. Our previous work showed humanized anti-CD47 antibody (anti-huCD47 mAb), an immune-modulatory drug increases phagocytic activity macrophages against cancer cells, has therapeutic...
Currently combinations of surgery, chemotherapy, and irradiation are utilized to treat pediatric malignant brain tumors; resulting in significant permanent morbidity. Recently we published the effect a humanized anti-CD47 antibody, Hu5F9-G4, on five aggressive etiologically distinct tumors: Group 3 medulloblastoma (primary metastatic), atypical teratoid rhabdoid tumor, primitive neuroectodermal glioblastoma, diffuse intrinsic pontine glioma. Hu5F9-G4 demonstrated therapeutic efficacy vitro...
Sangwon, Karl L. BS*; Esparza, Rogelio MD*; Sharashidze, Vera Dastagirzada, Yosef Shapiro, Maksim MD*,‡; Riina, Howard A. Lieberman, Seth MD§; Pacione, Donato Raz, Eytan MD, PhD*,‡; Nossek, Erez MD* Author Information