A5015545602- Cutaneous lymphoproliferative disorders research
- Nonmelanoma Skin Cancer Studies
- Cutaneous Melanoma Detection and Management
- Pneumocystis jirovecii pneumonia detection and treatment
- Eosinophilic Disorders and Syndromes
- HIV Research and Treatment
- Psoriasis: Treatment and Pathogenesis
- T-cell and B-cell Immunology
- Dermatology and Skin Diseases
- Lymphoma Diagnosis and Treatment
- T-cell and Retrovirus Studies
- Genetic and rare skin diseases.
- Tuberculosis Research and Epidemiology
- Virus-based gene therapy research
- Plant and Fungal Interactions Research
- Cancer Cells and Metastasis
- Dermatological and COVID-19 studies
- Reproductive tract infections research
- Hedgehog Signaling Pathway Studies
- Mast cells and histamine
- Ophthalmology and Visual Impairment Studies
- Wound Healing and Treatments
- Fungal Infections and Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- AI in cancer detection
Medical University of Vienna
2012-2025
Goethe Institut
2025
Goethe University Frankfurt
2025
Universitätszahnklinik Wien
2020-2021
We present a single-arm, phase II, neoadjuvant trial with the oncolytic virus talimogene laherparepvec (T-VEC) in 18 patients difficult-to-resect cutaneous basal cell carcinomas. The primary end point, defined as proportion of patients, who after six cycles T-VEC (13 weeks), become resectable without need for plastic reconstructive surgery, was already achieved stage I (9 patients; 50.0%); thus study discontinued early success. objective response rate 55.6% and complete pathological 33.3%....
Background. The sensitivity of whole-blood interferon-γ release assays to detect or predict active tuberculosis in individuals infected with human immunodeficiency virus type 1 (HIV-1) has as yet not been determined.
Diagnosis of skin cancer requires medical expertise, which is scarce. Mobile phone-powered artificial intelligence (AI) could aid diagnosis, but it unclear how this technology performs in a clinical scenario. Our primary aim was to test the clinic whether there equivalence between AI algorithms and clinicians for diagnosis management pigmented lesions.In multicentre, prospective, diagnostic, trial, we included specialist novice patients from two tertiary referral centres Australia Austria....
Targeting of the proinflammatory cytokine interleukin 17A (IL-17A) or tumor necrosis factor alpha (TNFα) with monoclonal antibodies (mAbs) ixekizumab adalimumab, respectively, is a successful therapy for chronic plaque psoriasis. The effects these treatments on immune cell populations in skin are largely unknown. In this study, we compared composition cutaneous, lesional and non-lesional cells blood ixekizumab- adalimumab-treated patients Our data reveal that both efficiently downregulate T...
Large-scale screening programs for vision impairments can incur substantial costs. Computer-based methods, which combine different measurements within a single system, facilitate and reduce the costs of such programs. Here, we present virtual reality (VR) software, includes tests assessment visual acuity, stereo eye misalignments interocular suppression as well games targeting functions that may serve treatment methods. The software be easily extended to incorporate new games. We proof...
Mycosis fungoides (MF) and Sézary syndrome (SS) are primary cutaneous T-cell lymphomas (CTCL) with not yet fully understood etiology pathogenesis. Conceptually, MF SS classified as distinct entities arising from different T helper cell subsets. is the most common CTCL entity, while very rare. presents clinically patch, plaque and/or tumor stages, but can also evolve erythroderma, which in turn pathognomonic for SS. characterized by a detectable tumor-cell burden (Sézary cells) peripheral...
ABSTRACT In this prospective, longitudinal study on 948 HIV-1-infected patients, subjects with an indeterminate IFN-γ (gamma interferon) release assay (IGRA) result at baseline were significantly higher risk of developing AIDS-defining manifestations other than tuberculosis (TB) irrespective CD4 + T cell count. Thus, in patients advanced quantitative depletion, IGRA might indicate additional loss global function, warranting detailed clinical evaluation and careful follow-up.
For the treatment of early infectious syphilis, enhanced therapy with three dosages benzathine penicillin G has been under consideration, particularly in human immunodeficiency virus type 1 infected population (HIV-1). The serological outcome 249 patients primary and secondary syphilis treated standard or was analyzed retrospectively; 98% (139/142) achieved cure a single dosage 92% (P=0.033). In HIV-1 individuals, rates were 88% after compared to 97% (P=0.18). A fourfold decrease Venereal...
To assess the association of smoking with interferon-gamma (IFN-γ) release assay and tuberculin skin test (TST) results in a comparative study on detection latent tuberculous infection (LTBI) human immunodeficiency virus (HIV) 1-infected individuals.In this cross-sectional study, 305 HIV-1-infected subjects were tested by QuantiFERON-TB Gold In-Tube (QFT-GIT) TST. We evaluated impact other LTBI risk factors QFT-GIT TST results. RESULTS The concordance both tests was 93% (κ = 0.71, P <...
The implications of infiltrative compared to non-infiltrative growth cutaneous basal cell carcinoma (BCC) on the tumor stroma and immune landscape are unknown. This is clinical importance, because BCCs, in contrast other BCC subtypes, more likely relapse after surgery radiotherapy.This descriptive cross-sectional study analyzed 38 BCCs collected from 2018 2021. In first cohort (n = 28), cells were characterized by immunohistochemistry multiplex immunofluorescence staining for CD3, CD8, CD68,...
Zusammenfassung Die Mycosis fungoides (MF) und das Sézary‐Syndrom (SS) sind primär kutane T‐Zell‐Lymphome (CTCL), deren Ätiologie Pathogenese noch nicht vollständig geklärt sind. MF SS werden konzeptionell als eigenständige Entitäten angesehen, mit unterschiedlichen T‐Helferzell‐Subtypen Ursprung. Während die den häufigsten Subtyp der CTCL darstellt, ist hingegen sehr selten. Klinisch bei Patch ‐, Plaque‐ Tumor‐Stadium unterschieden, wobei sich auch eine Erythrodermie manifestieren kann,...
Zusammenfassung Wir berichten über ein 20 Monate altes Mädchen mit teils anulären, urtikariellen Hautveränderungen am gesamten Integument, die bis zu 1 Woche persistierten und dann an neuen Stellen auftraten. Die histologische Aufarbeitung zeigte urtikarielles Entzündungsmuster interstitiellem Ödem einem Infiltrat Lymphozyten, Neutrophilen vielen eosinophilen Granulozyten ohne Flammenfiguren. Das Labor war unauffällig. In Zusammenschau stellten wir Diagnose eines anulären Erythems (EAE) im...
Summary The polymorphic presentation of annular dermatoses in the pediatric population renders them a diagnostic challenge to clinician. They include various distinct disease entities that can be vaguely categorized according age onset. Herein, we report on young girl with clinical characteristics Wells’ syndrome, while histological findings favored diagnosis erythema infancy (AEI). Although morphological and similarities do exist, AEI eosinophilic (EAE) childhood are considered as...
Abstract Targeting of the pro-inflammatory cytokines interleukin 17A (IL-17A) or tumor necrosis factor alpha (TNFα) with monoclonal antibodies (mAbs) ixekizumab adalimumab, respectively, are successful therapies in chronic plaque psoriasis. The effects these treatments on immune cell populations skin largely unknown. In this study, we compared composition cutaneous, lesional as well non-lesional, and blood cells adalimumab treated patients Our data reveal that both efficiently down-regulate...
Background: Early diagnosis of skin cancer requires specialised medical expertise, which is limited. However, there hope that mobile phone-powered artificial intelligence (AI) can bridge this gap, but it unclear how technology will perform in a realistic clinical scenario. Methods: We conducted multinational prospective trial to compare the accuracy expert and novice diagnostic management decisions with two types AI incorporating simple optical attachment; novel 7-class algorithm ISIC...