A5052570472- vaccines and immunoinformatics approaches
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Cancer Immunotherapy and Biomarkers
- Advanced Biosensing Techniques and Applications
- Immune Cell Function and Interaction
- Dermatology and Skin Diseases
- CAR-T cell therapy research
- Hematopoietic Stem Cell Transplantation
- Vector-borne infectious diseases
- Viral Infections and Vectors
- Cutaneous lymphoproliferative disorders research
- Computational Drug Discovery Methods
- Eosinophilic Disorders and Syndromes
- Mesenchymal stem cell research
- HIV Research and Treatment
- IL-33, ST2, and ILC Pathways
- Medicine and Dermatology Studies History
- Wound Healing and Treatments
- Extracellular vesicles in disease
- Toxin Mechanisms and Immunotoxins
- Hair Growth and Disorders
- Reproductive tract infections research
- Cytokine Signaling Pathways and Interactions
- S100 Proteins and Annexins
Medical University of Vienna
2016-2025
CeMM Research Center for Molecular Medicine
2019-2025
Austrian Academy of Sciences
2019-2025
Universitätszahnklinik Wien
2020-2024
Wellcome Sanger Institute
2023-2024
FH Campus Wien
2021-2022
University Dermatology
2021-2022
Fred Hutch Cancer Center
2014-2015
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
2015
Cancer Research Center
2015
Semen contains relatively ill-defined regulatory components that likely aid fertilization, but which could also interfere with defense against infection. Each ejaculate trillions of exosomes, membrane-enclosed subcellular microvesicles, have immunosuppressive effects on cells important in the genital mucosa. Exosomes general are believed to mediate inter-cellular communication, possibly by transferring small RNA molecules. We found seminal exosome (SE) preparations contain a substantial...
GVHD includes an autoinflammatory host-versus-graft component from recipient-derived skin-resident memory T cells.
Tenofovir gel is being evaluated for vaginal and rectal pre-exposure prophylaxis against HIV transmission. Because this a new prevention strategy, we broadly assessed its effects on the mucosa. In MTN-007, phase-1, randomized, double-blinded microbicide trial, used systems genomics/proteomics to determine effect of tenofovir 1% gel, nonoxynol-9 2% placebo or no treatment biopsies (15 subjects/arm). We also treated primary epithelial cells from four healthy women with in vitro. After seven...
Emigration of tissue-resident memory T cells (TRMs) was recently introduced in mouse models and may drive systemic inflammation. Skin TRMs patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) can coexist beside donor cells, offering a unique human model system to study migration. By genotyping, mathematical modeling, single-cell transcriptomics, functional analysis patient blood skin we detected small consistent population circulating skin-derived with TRM phenotype...
Adaptive features of natural killer (NK) cells have been reported in various species with different underlying mechanisms. It is unclear, however, which NK cell populations are capable mounting antigen-specific recall responses and how such functions regulated at the molecular level. Here, we identify characterize a discrete population CD49a+CD16- human liver that displays increased epigenetic potential to elicit memory has functional properties exert immunity skin as an effector site....
Background Tumor-associated macrophages (TAM) constitute the most abundant immune cells in tumor stroma initiating pro-inflammatory (M1) or immunosuppressive (M2) responses depending on their polarization status. Advances immunotherapy call for a detailed understanding of potential immunogenic mechanisms irradiation routinely applied rectal cancer patients. Methods To test effects radiotherapy TAM, we ex vivo irradiated tissue samples human and assessed phenotype by flow cytometry. We...
Abstract Purpose: Despite high clinical need, there are no biomarkers that accurately predict the response of patients with metastatic melanoma to anti-PD-1 therapy. Experimental Design: In this multicenter study, we applied protein depletion and enrichment methods prior various proteomic techniques analyze a serum discovery cohort (n = 56) three independent validation cohorts 80, n 12, 17). Further analyses by literature survival analysis followed. Results: We identified several...
During cutaneous tick attachment, the feeding cavity becomes a site of transmission for salivary compounds and tick-borne pathogens. However, immunological consequences human skin remain unclear. Here, we assessed blood samples upon bite developed explant model mimicking Ixodes ricinus bites pathogen infection. Following observed rapidly occurring patterns immunomodulation, including increases in neutrophils B T cells. cells upregulated tissue residency markers, while lymphocytic cytokine...
Patients with polymorphic light eruption (PLE) develop lesions upon the first exposure to sun in spring/summer, but usually subside during season due natural (or medical) photohardening. However, these tend reappear following year and continue do so most patients, suggesting presence of a disease memory. To study potential role skin resident memory T cells (Trm), we investigated functional phenotype Trm expression IL-15 PLE. is known drive proliferation survival. Multiplex immunofluorescence...
Cutaneous T cell lymphoma (CTCL) is a potentially fatal clonal malignancy of cells primarily affecting the skin. The most common form CTCL, mycosis fungoides, can be difficult to diagnose, resulting in treatment delay. We performed single-cell and spatial transcriptomics analysis skin from patients with fungoides-type CTCL an integrated comparative human atlas datasets healthy inflamed revealed co-optation helper 2 (T
Abstract Background Graft-versus-host disease (GvHD) is a major life-threatening complication of allogeneic haematopoietic stem cell transplantation (HSCT), limiting the broad application HSCT for haematological malignancies. Cutaneous GvHD described as post-transplant inflammatory reaction by skin-infiltrating donor T cells and remaining recipient tissue-resident memory cells. Despite influence lymphocytes on pathogenesis, complex role mononuclear phagocytes (MNPs) in tissues affected...
Aluminium salts have been used in vaccines for decades. However, the mechanisms underlying their adjuvant effect are still unclear. Neutrophils, first immune cells at injection site, can release cellular DNA together with granular material, so-called neutrophil extracellular traps (NETs). In mice, NETs apparently play a role aluminium hydroxide (alum)-adjuvant response to vaccines. Although no experimental data exist, this is assumed be operative also humans. As step verify knowledge humans,...
Chemokine receptors and their ligands have been identified as playing an important role in the development of diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, Richter syndrome (RS). Our aim was to investigate different expression profiles de novo DLBCL, transformed (tFL), RS. Here, we profiled mRNA levels 18 chemokine (CCR1–CCR9, CXCR1–CXCR7, CX3CR1 XCR1) using RQ-PCR, well immunohistochemistry seven (CCR1, CCR4–CCR8 CXCR2) RS, tFL biopsy-derived tissues. Tonsil-derived germinal...