Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of global mortality, primarily driven by an abnormal inflammatory response to harmful particles and gases. This review explores the epigenetic mechanisms underlying COPD pathogenesis their therapeutic implications. A comprehensive literature was conducted, analyzing recent findings on DNA methylation, histone modifications, noncoding RNAs (ncRNAs) in COPD. Key studies highlighting impact these changes inflammation, cellular...

Recent studies have highlighted that chest CT scans are crucial for accurately diagnosing COVID-19. However, in rural areas of Indonesia, people may difficulty assessing scans, leading to increased undetected cases. To address this issue, we investigated whether X-rays (CXR) could replace COVID-19 patients. A diagnostic cross-sectional-based study was conducted at Fatmawati General Hospital from January September 2021. The included suspected patients isolation wards and ICU who were over 18,...

Risk of chronic pulmonary emphysema from exposure to tobacco smoke varies widely person person, depending in part on the status particular genes and acquired susceptibilities. Certain determine how cells activate and/or detoxify products. We aimed whether any genetic susceptibility exists development emphysematous changes confirmed by chest computed tomography (CT). Genotypes various enzymes involved activation or detoxification smoke, epoxide hydrolase (EPHX1), cytochrome P450s (CYP1A1...

Objective: Andrographis paniculata has long been a traditional medicinal plant in Indonesia. This study is intended to evaluate the anti-pro-inflammatory cytokines of 98% ethanol extract A. by vitro and silico approaches. Inhibition pro-inflammatory also one therapies treating COVID-19. Methods: The molecular docking approach was utilized as first screening potential for suppression macrophage cell activation; an ADMET prediction test performed determine pharmacological, pharmacokinetic,...

Genetic factors contribute as major determinants in the pathophysiological mechanisms of chronic obstructive pulmonary disease (COPD). Therefore, identification candidate genes and various gene polymorphisms have improved our understanding COPD.Clarify genes, including HIF1A, that to development COPD.We compared genotype frequencies 12 seven detoxification-related (GSTM1, GSTT1, GSTP1 exon 5, CYP1A1 7, 3'-flanking, CYP2E1 intron 6, 5'-flanking, EPHX1 3, 4 HMOX1 promoter) hypoxia-related...

Coronavirus disease-2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) manifests in a broad clinical spectrum. COVID-19 survivors report various symptoms up to several months after being infected. The purpose of this study was determine prevalence persistent Indonesia, factors that influence incidence, and quality life.This cross-sectional with an online questionnaire conducted January 2021. Inclusion criteria were: adult Indonesian citizens who had...

Andrographis paniculata Burm. F Nees used to treat COVID-19 in several Asian countries because it has metabolites with pharmacological activity that may decrease the pathogenesis features of COVID-19. The extraction solvent significantly affected composition and concentration metabolites. Therefore, inhibitory effects nitric oxide A. extract based on differences concentrations were investigare also identified its metabolite profile. leaves extracted three different solvents like water...

BACKGROUND Indonesia forest fire in 2015 emitted a huge amount of pollutants into the air. This study was aimed to assess health consequences smoke healthy residents Riau during disaster 2015.
 METHODS cross-sectional performed who lived Pekanbaru, Province, Sumatera, for at least 6 months 2015, and data were taken October 2015. Questionnaires consisting respiratory non-respiratory symptoms collected. Lung function assessed by spirometry (MIR II Spirolab™ spirometer, Medical...

Over 43 million Indonesian children who are exposed to cigarette smoke at risk of having health hazard and morbidities.The aim this study is identify the correlation between exposure respiratory complaints, hospitalization, as well school absence due complaints in elementary school-aged children.A cross-sectional was conducted nonsmoking children. Participants were categorized into unexposed groups based on report their parents. Questionnaire-retrieved data analyzed total 128 participants...

Background: Obstructive sleep apnea (OSA) is closely associated with metabolic diseases such as hypertension and dyslipidemia. OSA also frequently found in patients heart failure. This study aims to determine the prevalence factors which affect incidence of Methods: cross-sectional was conducted on 70 samples failure cardiac outpatient clinic inpatient ward Persahabatan Hospital, Jakarta, Indonesia. Results: Using Berlin Questionnaire, 42 (60%) were be at high risk OSA. Chi-square test, it...

The increasing prevalence of drug user in Indonesia is affecting the health sectors. lungs were affected by use illicit drug. However, lung function among users still unclear.This descriptive-analytic study involves 144 who met inclusion criteria. Chest X-ray was performed to identify subject with pulmonary tuberculosis exclude from study. Subjects then undergone spirometry test and interviewed using questionnaires.One hundred forty-four subjects included this One twenty-one (84.03%) male...

Pedoman yang dikeluarkan oleh World Health Organization dibuat untuk mengurangi pengaruh buruk polusi udara.Polutan utama terdapat di udara yatiu PM, O3, NO2, SO2 . Polutan tersebut paling besar bersumber dari aktivitas industry dan asap kendaraan bermotor.Polusi mempunyai hubungan dengan eksaserbasi pada asma, peningkatan reaktivitas bronkus, bertambahnya gejala rawat inap kunjungan ke unit gawat darurat.Beberapa penelitian menyatakan bahwa peranan dalam terjadinya asma.Prevalens derajat...

Background: Cytokine storm or hyperinflammation condition in COVID-19 patients could result fatal outcomes. Inflammation also coagulation disorders. The Neutrophil-Lymphocyte Ratio (NLR) and Platelet-lymphocyte ratio (PLR) have been known as inflammation markers several diseases. D-dimer value can be used to assess a patient's status. Further study on thromboinflammation biomarkers is needed. Therefore, we conducted the association between NLR, PLR, d-dimer clinical outcome of confirmed at...

Background: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. Most these deaths are related to cardiovascular disease. This due systemic inflammation that causes increased vascular stiffness and hypertension. These comorbidities lead poor quality life, low exercise tolerance, an risk hospitalization. study aims report proportion hypertension among stable COPD patients in Indonesian population.Methods: cross-sectional was conducted at National...

Background: Environmental tobacco smoking exposure increased the level of urine cotinine and exhaled carbon monoxide (COex). Evidence suggests that there is an association between nicotine dependence COex. The purpose this study to elucidate correlation urinary cotinine, COex, among Indonesian individuals with a history substance use undergoing rehabilitation program. Materials Methods: This cross-sectional recruited participants who undergone at unit in Lido, aged >18 years old, current...

Diagnosis of a pneumothorax in some cases the can be difficult. Traditional gold-standard modalities may not available or feasible to institute. In this situation, thoracic sonography for especially helpful, allowing method quickly ruling out potentially life-threatening complication. Its sensitivity dan specificity ultrasound is higher than conventional chest x-ray. The four sonograms useful diagnose and their usefulness condition are lung sliding, pulse, B-lines point. (J Respir Indo....

Pulmonary emphysema is part of pathological condition in chronic obstructive pulmonary disease (COPD) which characterized by lung parenchymal destruction. Morphology classification had been made according to histologic structure pathology. There were some causes known be the culprit emphysema; one that caught most attention protease-antiprotease activity from cigarette smoke exposure. Destructive effect gives disturbance function expiration (obstruction). The primary mechanism elastic recoil...