A5065892487- Medicinal Plant Research
- Agricultural and Biological Research
- Probiotics and Fermented Foods
- Food and Agricultural Sciences
- Protein Hydrolysis and Bioactive Peptides
- Dengue and Mosquito Control Research
- Natural Antidiabetic Agents Studies
- Electrochemical sensors and biosensors
- Natural product bioactivities and synthesis
- Gout, Hyperuricemia, Uric Acid
- Microbial Metabolic Engineering and Bioproduction
- Microbial metabolism and enzyme function
- Insect Pest Control Strategies
- Pharmacological Effects of Natural Compounds
- Insect Utilization and Effects
- Microfluidic and Capillary Electrophoresis Applications
- Moringa oleifera research and applications
- Plant tissue culture and regeneration
- Natural Products and Applications
- Natural Compound Pharmacology Studies
- Phytoestrogen effects and research
- Medicinal Plants and Neuroprotection
- Pharmacology and Obesity Treatment
- Enzyme Catalysis and Immobilization
- Ginger and Zingiberaceae research
IPB University
2004-2025
University of Nusa Cendana
2021
Institut Teknologi Kalimantan
2017
Kyoto University
1998-2002
Fermented milk can be used to produce antihypertensive peptides. Lactic acid bacteria (LAB) with its proteolytic system hydrolyze protein during fermentation several peptides, which include bioactive This study aimed investigate the ability of indigenous LAB for production angiotensin-I-converting enzyme inhibitory (ACE-I) peptides in fermented and characterize ACEI peptides.Reconstituted (11%) inoculated ten isolates, then incubated at 37°C until it reaches pH 4.6. The evaluation was...
Zingiber cassumunar Roxb. (Bangle), Guazuma ulmifolia Lamk. (Jati belanda), and Murraya paniculata (Kemuning) have been used as slimming agents in jamu. A few researches performed studies on their potency antiobesity. The aim of this research was to investigate the Z. rhizome, G. ulmifolia, M. leaf extracts antiobesity agent based vitro inhibition activity pancreatic lipase activity. In research, water content determination, phytochemical assay, toxicity assay were toward single mixture...
In this study, angiotensin-I-converting enzyme inhibitory (ACEI) activity was evaluated in fermented goat milk by lactic acid bacteria (LAB) from foods and breast milk. Furthermore, the potential for ACEI peptides identified with highest activity. The proteolytic specificity of LAB also evaluated. 2% isolate inoculated into reconstituted (11%, w/v), then incubated at 37°C until pH 4.6 reached. supernatant produced centrifugation analyzed total peptide. Viable cell counts titratable acidity...
Objective: Andrographis paniculata has long been a traditional medicinal plant in Indonesia. This study is intended to evaluate the anti-pro-inflammatory cytokines of 98% ethanol extract A. by vitro and silico approaches. Inhibition pro-inflammatory also one therapies treating COVID-19. Methods: The molecular docking approach was utilized as first screening potential for suppression macrophage cell activation; an ADMET prediction test performed determine pharmacological, pharmacokinetic,...
Indonesia is a tropical country with mega-biodiversity. Several medicinal plants locally have been recognized for their anti-inflammatory properties and are traditionally used to help treat respiratory diseases. Chronic obstructive pulmonary disease (COPD) one of the diseases known as high cause death globally, treatment efforts by using drugs. In developing alternative remedies COPD, this review summarizes potential Indonesian ingredients an activity develop COPD. Primarily, we focus on...
Apo-glucose dehydrogenase existing in Escherichia coli is converted to the holoenzyme with exogenous pyrroloquinoline quinone (PQQ) and Mg(2+). Catalytic behaviour of E. cells characterized by a Michaelis-Menten-type equation catalytic constant cell apparent Michaelis constants for D-glucose an artificial electron acceptor added suspension. The expressed as product number molecules enzyme contained (z) (k(cat)), which were determined be 2.2x10(3) 6.8+/-0.8x10(3) s(-1) (phenazine...
Abstract Efforts to isolate compounds from an Indonesian member of the ginger family, Kaempferia angustifolia, yielded three known molecules, identified as (+)-crotepoxide (1), (+)-pipoxide chlorohydrin (2), and flavokawain A (FKA, 3). All strongly inhibited triglyceride accumulation in 3T3-L1 murine pre-adipocytes at 10 µg/mL, 1 2 were both cytotoxic this concentration. To determine biological activities natural 3, flavokawains (3), B (4) C (5) synthesized. While 4 was cytotoxic, 3 5...
Asam gelugur fruits of Garcinia often used to reduce body weight. Lengkuas and kencur are traditional herbal that potential for antiobesity because they could the level phospholipids, triglycerides, cholesterol. The aim research was evaluate potencies these as by measurement their water ethanol extracts capabilities in vitro inhibitor pancreatic lipase activity. asam contained saponins alkaliods, respectively. extract lengkuas rhizomes alkaloids, flavonoids, saponins, quinones, while...
The traditional medicine has been used in Indonesia since the days of Ancient Mataram Kingdom (about 12 centuries ago). is rich medicinal plants. For this reason, it necessary to inform broader community regarding plants that have potential as antigout. prevalence gout range 1.6−13.6 per 100,000 people and will increase with age. There are 25 species Indonesian more than 50% xanthine oxidase (XO) enzyme inhibitory activity. XO responsible for catalyzing hypoxanthine then producing uric acid,...
Hyperuricemia is a condition characterized by levels of blood's uric acid that higher than its normal levels. If left unchecked, hyperurecemia will trigger gout, an accumulation mononosodium urate crystals caused disruption purine metabolism in the joints, periarticular tissues, bones and other organs. Xantine oxidase (XO) enzyme plays role reaction hypoxantine oxidation to xantine becomes acid. Therefore, inhibition XO activity main focus treatment gout. Some medicinal plants are known...
Galangal is widely cultivated for the multifunctional plant. This study analyzed essential oil chemical components, metabolite profiles, and idioblast cell densities in seven galangal accession grown at two different altitudes (locations A B). The accessions included: Purbalingga, Cilacap, Purworejo, Karanganyar, Pacitan, Madiun, Galesia 2 which was used as control. results showed that highest content obtained from MAD (3.22%) location A. levels of ethyl-p-methoxycinnamate (EPMC) were PBG...
Abstract. Rubak YT, Nuraida L, Iswantini D, Prangdimurti E, Sanam MUE. 2021. Peptide profiling of goat milk fermented by Lactobacillus delbrueckii ssp. BD7: Identification potential biological activity. Biodiversitas 22: 3136-3145. This study investigated the angiotensin-converting enzyme (ACE) inhibitory activity in BD7, characterizing peptide and its as a bioactive peptide. The starter culture (2%) was inoculated into pasteurized skim (11%), then incubated at 37 °C until it reached pH 4.6....
<p>Endophytic <em>Streptomyces </em>sp. AEBg12 isolated from <em>Zingiber</em><em> </em><em>cassumunar</em><em> </em>(Bangle) is known to produce pancreatic lipase inhibitory compound. However, the characteristics of this active compound has not been reported yet. This study aimed determine pancreatics produced by and assess role endophytic actinobacteria in producing inhibitor using endophytic-free bangle tissue culture, wild...
Andrographis paniculata Burm. F Nees used to treat COVID-19 in several Asian countries because it has metabolites with pharmacological activity that may decrease the pathogenesis features of COVID-19. The extraction solvent significantly affected composition and concentration metabolites. Therefore, inhibitory effects nitric oxide A. extract based on differences concentrations were investigare also identified its metabolite profile. leaves extracted three different solvents like water...
This work describes the development of an electrochemical biosensor method based on bacterial consortia to determine antioxidant capacity. The consortium used is a combination bacteria from genera Bacillus and Pseudomonas which can produce enzymes tyrosinase laccase. were immobilized surface screen-printed carbon electrode (SPCE) form biofilm. Biofilms selected highest current response evaluated electrochemically using cyclic voltammetry analysis techniques. Optimum biofilm conditions...
Gout is a joint disease caused by the accumulation of uric salt crystals that causes an acute inflammatory response, or these in soft tissue (cartilage).Cat's whiskers leaves (Orthosiphon aristatus), bitter herbs (Andrographis paniculata), and snake fruit (Salacca zalacca) are native Indonesian plants commonly used to reduce acid levels body.This study tested bioactive potency xanthine oxidase enzyme inhibition vitro water ethanol extracts from three evaluate their as antigout.The...
<abstract> <p>The modification of Takari natural sand‑based silica with bovine serum albumin/BSA (SiO<sub>2</sub>@BSA) as an adsorbent for biogenic amines compounds has been successfully synthesized. The SiO<sub>2</sub>@BSA was synthesized by using the batch method, then characterized FTIR and SEM. Here, A typical BSA group identified new formed namely C–N C–H, N–H. SEM image shows surface morphology in granular, non‑uniform, rough, agglomerated forms....