A5005963923- Child and Adolescent Health
- Gut microbiota and health
- Maternal Mental Health During Pregnancy and Postpartum
- Tuberous Sclerosis Complex Research
- Research in Social Sciences
- Clostridium difficile and Clostridium perfringens research
- Child Abuse and Trauma
- Bariatric Surgery and Outcomes
- Gestational Diabetes Research and Management
- Probiotics and Fermented Foods
- Psychiatric care and mental health services
- Obesity and Health Practices
- Geriatric Care and Nursing Homes
- Obesity, Physical Activity, Diet
- Primary Care and Health Outcomes
- Bullying, Victimization, and Aggression
- Homelessness and Social Issues
- Nursing Roles and Practices
- Breastfeeding Practices and Influences
- School Health and Nursing Education
- Ethics in Clinical Research
- Counseling, Therapy, and Family Dynamics
- Youth Development and Social Support
- Interprofessional Education and Collaboration
- Mental Health and Patient Involvement
Cardiff University
2014-2024
University of Oxford
2016
University of York
2016
Primary Health Care
2016
University of South Wales
2016
University of Nottingham
2016
University of Bristol
2016
University of Wales
1999-2004
University Hospital of Wales
2002
Background Obesity has significant health and NHS cost implications. Relatively small reductions in weight have clinically important benefits, but long-term loss maintenance (WLM) is challenging. Behaviour change interventions been identified as key for WLM. Motivation crucial to supporting behaviour change, motivational interviewing (MI) a successful approach changing behaviours. The study was designed an adequately powered, pragmatic randomised controlled trial (RCT); however, owing...
The Nurse Family Partnership programme was developed in the USA where it is made available to pregnant young mothers some socially deprived geographic areas. related introduced England by Department of Health 2006 with aim improving outcomes for health, wellbeing and social circumstances first-time their children.This multi-centre individually randomised controlled trial will recruit 1600 participants from 18 Primary Care Trusts England, United Kingdom. evaluate effectiveness usual care...
Probiotics are frequently used by residents in care homes (residential or nursing that provide with 24-hour support for personal care), although the evidence on whether probiotics prevent infections and reduce antibiotic use these settings is limited.To determine a daily oral probiotic combination of Lactobacillus rhamnosus GG Bifidobacterium animalis subsp lactis BB-12 compared placebo reduces administration home residents.Placebo-controlled randomized clinical trial 310 residents, aged 65...
Abstract Background Childhood bullying is a public health priority. We evaluated the effectiveness and costs of KiVa, whole-school anti-bullying program that targets peer context. Methods A two-arm pragmatic multicenter cluster randomized controlled trial with embedded economic evaluation. Schools were to KiVa-intervention or usual practice (UP), stratified on school size Free School Meals eligibility. KiVa was delivered by trained teachers across one year. Follow-up at 12 months post...
The gene expression of a new group tumour antigens known as cancer/testis (CT) is now well-recognized in some solid tumours. However, their haematological malignancies remained unclear. In this study, we have used reverse transcription polymerase chain reaction and Southern blot analysis to examine the presence transcripts for three CT antigens, NY-ESO-1, SSX2 SCP1 malignant cells. We found that could be detected 10% myeloma, 5.7% acute myeloid leukaemia 23% chronic leukaemia. contrast,...
Approximately 1 in 5 pregnant women the United Kingdom are obese. In addition to being associated generally with poor health, obesity is known be a contributing factor pregnancy and birth complications retention of gestational weight can lead long term obesity. This paper describes protocol for cluster randomised trial evaluate whether management intervention obese effective reducing women's Body Mass Index at 12 months following birth. The study controlled involving 20 maternity units...
Aging is associated with changes to the immune system, collectively termed immunosenescence and inflammageing. However, relationships among age, frailty, parameters in older people resident care homes are not well described. We assessed inflammatory 184 United Kingdom home residents aged over 65 years how they relate frailty index, length of residence. Linear regression was used identify independent contribution residence various as dependent variables. Participants had a mean age (±SD) 85.3...
Background. Several different models of out-of-hours primary care now exist in the UK. Important outcomes include users' satisfaction and enablement to manage their illness or condition, but determinants these unscheduled domain are poorly understood.
Aging is associated with a decline in many components of the immune system (immunosenescence). Probiotics may improve response older people. The objective was to determine effect combination two probiotic organisms [Lacticaseibacillus (previously known as Lactobacillus) rhamnosus GG (LGG) and Bifidobacterium animalis subsp. lactis, BB-12 (BB-12)] on range biomarkers measured blood people resident care homes UK. In randomized controlled trial, [aged 67-97 (mean 86) years] received LGG+BB-12...
Tuberous sclerosis complex (TSC) is a genetic disorder affecting about 1 in 6000 people and characterised by the development of tumours many organs, including skin kidneys, range neurological neuropsychiatric manifestations. TSC-associated disorders (TAND) occur majority those with TSC, they have significant impact on patients their families, given everyday TAND education, employment, family social life. The potential benefits better treatment for therefore include reduction health care...
Objectives Measure effectiveness of family nurse partnership (FNP) home-visiting programme in reducing maltreatment and improving maternal health child health, developmental educational outcomes; explore effect moderators, mediators; describe costs. Design Follow-up BB:0–2 trial cohort (ISRCTN:23019866) up to age 7 years England using record linkage. Participants 1618 mothers aged 19 or younger their firstborn child(ren) recruited at less than 25 weeks gestation not mandatorily withdrawn...
Background The short-term effectiveness (to 24 months post partum) of a preventative home-visiting intervention, the Family Nurse Partnership, was previously assessed in Building Blocks trial (BB:0–2). Objectives objectives were to establish medium-term Partnership reducing maltreatment and improving maternal health (second pregnancies) child health, developmental educational outcomes (e.g. early attendance, school readiness); explore effect moderators mediators; describe costs enhancing...
Abstract Objective To assess whether a weight management intervention for pregnant women with obesity was effective in reducing body mass index (BMI) 12 months after giving birth. Methods Pragmatic, cluster randomised controlled trial (RCT) embedded cost-effectiveness analysis. 598 BMI of ≥30 kg/m 2 (between and 20 weeks gestation) were recruited from secondary care maternity units England Wales. at postpartum the primary outcome. A range clinical behavioural outcomes examined. Interventions...
Child maltreatment involves acts of omission (neglect) or commission (abuse) often by caregivers that results in potential actual harm to a child. The Building Blocks trial (ISRCTN23019866) assessed the short-term impact an intensive programme antenatal and postnatal visiting specially trained nurses support young pregnant women England. Blocks: 2-6 Study will assess medium-term impacts for mothers children (n=1562), through linkage routinely collected data data, with particular emphasis on...
Introduction Care home residents are at increased risk of infections and antibiotic prescription. Reduced use from fewer would improve quality life. The P robiotics to R educe I nfections i N C ar E re S ident (PRINCESS) trial aims determine the efficacy investigate mechanisms daily probiotics on incidence in care residents. Methods analysis PRINCESS is a double-blind, individually randomised, placebo-controlled that will assess effect oral probiotic combination Lactobacillus rhamnosus, GG...
Background. Considerable changes have occurred over the last 5 years in organization of out-of-hours care UK. Users' experiences their are an important part 'quality care' and valuable for identifying areas improvement.
Abstracted from Lancet 2016;387:146–155 Individual, social, and economic circumstances faced by teenage mothers can challenge a successful start for children interrupt mothers' long-term socioeconomic stability. The Family-Nurse Partnership (FNP) is licensed intensive home-visiting intervention developed in the United States introduced into practice England.
Building Blocks is a randomised controlled trial evaluating the effectiveness of Family Nurse Partnership (FNP) programme in 18 sites England. FNP home visiting intervention aiming to address social exclusion and health disadvantage. Participants were 1600 teenage mothers, living often challenging circumstances. Recruitment usually followed an initial approach by community midwife but also other local or care professionals.