A5059049103- Advanced ceramic materials synthesis
- Advanced materials and composites
- RNA Interference and Gene Delivery
- Corneal surgery and disorders
- Advanced biosensing and bioanalysis techniques
- MXene and MAX Phase Materials
- Metal and Thin Film Mechanics
- Glaucoma and retinal disorders
- Corneal Surgery and Treatments
- Retinal and Optic Conditions
- Lipid Membrane Structure and Behavior
- Antimicrobial Peptides and Activities
- Cellular Mechanics and Interactions
- Silk-based biomaterials and applications
- Diamond and Carbon-based Materials Research
- Essential Oils and Antimicrobial Activity
- Ocular Surface and Contact Lens
- Advancements in Transdermal Drug Delivery
- Electrospun Nanofibers in Biomedical Applications
- Piperaceae Chemical and Biological Studies
- Nanoplatforms for cancer theranostics
- Toxin Mechanisms and Immunotoxins
- Marine Toxins and Detection Methods
- Healthcare Operations and Scheduling Optimization
- Retinopathy of Prematurity Studies
Sankara Nethralaya
2016-2025
Oil and Natural Gas Corporation (India)
2015-2024
Creative Commons
2023
Saveetha University
2023
The University of Texas at Arlington
2020
Nanobiotix (France)
2019
Anna University, Chennai
2012
Max Planck Institute for Intelligent Systems
2002-2009
Max Planck Society
2002-2009
Stockholm University
2006
Abstract Background Epithelial cell adhesion molecule (EpCAM) is overexpressed in solid tumors and regarded as a putative cancer stem marker. Here, we report that employing EpCAM aptamer (EpApt) siRNA (SiEp) dual approach, for the targeted delivery of to positive cells, efficiently inhibits proliferation. Results Targeted using polyethyleneimine one efficient methods gene delivery, thus, developed novel aptamer-PEI-siRNA nanocomplex targeting. PEI synthesized with showed 198 nm diameter...
Amorphous Si‐B‐C‐N ceramic powder samples obtained by thermolysis of boron‐modified polysilazane, {B[C 2 H 4 Si(H)NH] 3 } n , were isothermally annealed at different temperatures (1400–1800°C) and hold times (3, 10, 30, 100 h). A qualitative semiquantitative analysis the crystallization behavior materials was performed using X‐ray diffraction (XRD). The phase evolution additionally followed 11 B 29 Si MAS NMR as well FT‐IR spectroscopy in transmission diffuse reflection (DRIFTS) modes. Bulk...
Background: Fungal keratitis is a major cause of corneal blindness accounting for more than one-third microbiologically proven cases. The management fungal through topical or systemic antifungal medications alone in combination with surgical treatment. Topical such as natamycin and voriconazole pose challenges due to poor penetration across the epithelium. To address issue various carrier molecules like nanoparticles, lipid vesicles, cell penetrating peptides were explored. But drawback...
Preparation of hybrid exosom-like nanovesicles from turmeric and pepper with novel attributes.
Fuchs endothelial corneal dystrophy (FECD) is a progressive disorder characterized by excessive extracellular matrix (ECM) accumulation and cell death. CTG trinucleotide repeat expansion in the transcription factor 4 (TCF4) gene represents most significant genetic risk factor. This study aimed to elucidate role of TCF4 FECD pathogenesis through comprehensive proteomic analysis. Corneal cells isolated from patients with harboring were immortalized establish an model (iFECD)....
Abstract Keratoconus (KC) is a corneal dystrophy characterized by progressive ectasia that leads to severe visual impairment and remains one of the leading indications for transplantation. The etiology believed be multifactorial alterations have been documented in biomechanical, biochemical ultrastructural characteristics cornea. While exact site disease origin still debated, changes epithelium are occur even before clinically manifested. In this study we investigate possible role β-catenin...
Due to its numerous reported benefits, including biomimetic, immunomodulation, and compatibility with tissue microenvironment, natural bio composite nanomaterials are in demand as an effective replacement the field of engineering. As a result, this study, we investigated polysaccharides containing materials from Coriandrum sativum(CS) Trigonella foenum-graecum(TFG) create nanofiber matrix polyvinyl alcohol (PVA). Drug-free drug-containing versions have been developed. Zeta potential, Fourier...
The plastic deformation of the precursor‐derived Si–C–N ceramics during indentation at room temperature displays permanent densification and creep, former effect promoting strain hardening. This paper attempts to quantify above two phenomena in these materials using, (i) reverse analysis nanoindentation load–displacement curves terms yield stress (σ y ) hardening exponent ( n ), (ii) creep rate sensitivity m respectively. estimated values were commensurate with capacity for densification,...
Purpose: Age-related macular degeneration (AMD) is one of the leading causes irreversible central vision loss in elderly population. The current study aims to find non-invasive prognostic biomarkers urine specimens AMD patients. Methods: Peripheral blood and samples were collected from 23 controls 61 Genomic DNA was extracted buffy coat peripheral blood. Allele specific PCR used assay SNPs complement factor H (CFH), component 3 (C3). Comparative proteomic analysis early AMD, choroidal...
Purpose: To study the efficacy and safety profile of topical absolute ethanol in treatment Pythium insidiosum keratitis. Method: Microbiological, clinical, histopathological assessments were performed to effects on P. In addition, infrared spectroscopy was assess corneal penetration ethanol. Results: Microbiological tests revealed that inhibited growth at concentrations even as low 20% compared Candida albicans Aspergillus flavus , where minimal noted. However, 40%, 60%, 80%, 99.9% ethanol,...