A5100456058- Genomics and Phylogenetic Studies
- Chromosomal and Genetic Variations
- Geology and Paleoclimatology Research
- RNA modifications and cancer
- Plant and Fungal Species Descriptions
- Genetic diversity and population structure
- Isotope Analysis in Ecology
- Genetic Mapping and Diversity in Plants and Animals
- Plant Ecology and Taxonomy Studies
- Identification and Quantification in Food
- Epigenetics and DNA Methylation
- Plant Molecular Biology Research
- Cancer Genomics and Diagnostics
- CRISPR and Genetic Engineering
- Plant Disease Resistance and Genetics
- Advanced biosensing and bioanalysis techniques
- RNA and protein synthesis mechanisms
- RNA Interference and Gene Delivery
- Pleistocene-Era Hominins and Archaeology
- Cancer-related molecular mechanisms research
- Ginseng Biological Effects and Applications
- Plant and Fungal Interactions Research
- Cholinesterase and Neurodegenerative Diseases
- Botanical Studies and Applications
- DNA and Nucleic Acid Chemistry
Zhejiang University
2024-2025
First Affiliated Hospital Zhejiang University
2025
North Sichuan Medical University
2025
East China Normal University
2022-2024
Changchun University
2024
Institute of Geology and Geophysics
2020-2023
Chinese Academy of Sciences
2015-2023
Institute of Botany
2023
Institute of Zoology
2016-2022
State Key Laboratory of Integrated Management of Pest Insects and Rodents
2021-2022
Seasonal biases (the warm-season contribution) of Holocene mean annual temperature (MAT) reconstructions from geological records were proposed as a possible cause the mismatch with climate simulated temperature. Here we analyze terrestrial mollusk assemblages that best reflect seasonal signals and provide quantitative MAT four-season for northern China during past 20,000 years. The estimated temperatures four-season-mean based on mollusks shows peak ~9000-4000 years ago, followed by cooling...
Efficient optical clearance is fundamental for whole brain imaging. In particular, of the without membrane damage required imaging lipophilic tracer-labeled neural tracts. Relying on an ascending gradient fructose solutions, SeeDB can achieve sufficient transparency mouse while ensuring that plasma remains intact. However, it challenging to extend this method larger mammalian brains due extremely high viscosity saturated solution. Here we report a SeeDB-derived clearing method, termed FRUIT,...
5hmC, 6mA, and 4mC are three common DNA modifications involved in various of biological processes. Accurate genome-wide identification these sites is invaluable for better understanding their functions. Owing to the labor-intensive expensive nature experimental methods, it urgent develop computational methods detection sites. Keeping this mind, current study was devoted construct a method identify 4mC. We initially used K-tuple nucleotide component, chemical property frequency,...
The course, tempo and mode of chloroplast genome evolution remain largely unknown, resulting in limited knowledge about how plant plastome gene evolve during the process recent speciation. Here, we report complete plastomes 22 closely related
In a broad range of taxa, genes can duplicate through an RNA intermediate in process mediated by retrotransposons (retroposition). mammals, L1 drive retroposition, but the elements responsible for retroposition other animals have yet to be identified. Here, we examined young retrocopies from various that still retain sequence features indicative underlying mechanism. Drosophila melanogaster, identified and de novo assembled 15 polymorphic found all retroposed loci are chimeras internal...
Tea is the most popular non-alcoholic caffeine-containing and oldest beverage in world. In this study, we de novo assembled chloroplast (cp) mitochondrial (mt) genomes of C. sinensis var. assamica cv. Yunkang10 into a circular contig 157,100 bp two complete scaffolds (701719 177329 bp), respectively. We correspondingly annotated total 141 cp genes 71 mt genes. Comparative analysis suggests repeat-rich nature genome compared to genome, for example, with characterization 37,878 149 long repeat...
Eutrema is a genus in the Brassicaceae, which includes species of scientific and economic importance. Many are montane and/or alpine that arose very recently, making them ideal candidates for comparative studies to understand both ecological speciation high-altitude adaptation plants. Here we provide de novo whole-genome assemblies pair recently diverged perennials with contrasting altitude preferences, E. heterophyllum from eastern Qinghai-Tibet Plateau its lowland congener yunnanense. The...
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder, but no drugs can cure this disease. Chalcones possess good antioxidant activity, anti-neuroinflammatory neuroprotective effects, inhibitory effects on Aβ aggregation, and disaggregation ability. Therefore, chalcones are ideal lead compounds, discovery of novel anti-AD agent-based necessary. Hydroxy groups aryl benzyl ether were introduced into chalcone scaffolds to obtain a series 2-hydroxyl-4-benzyloxy derivatives....
Two new bis(benzimidazole)aryl derivatives have been prepared and one of them has shown to induce stabilize formation a G-quadruplex.
Zizania latifolia (Griseb.) Turcz. ex Stapf was once utilized as an important grain in ancient China and has been cultivated aquatic vegetable. Here, we report the complete Z. chloroplast genome sequence obtained through de novo assembly of Illumina paired-end reads generated by directly purified (cp) DNA sequencing. The cp is 136,501 bp length, comprising a pair 20,878-bp inverted repeat regions (IR) separated small large single copy (SSC LSC) 12,590 82,155 bp, respectively. encodes 110...
The accurate and prompt diagnosis of infections is essential for improving patient outcomes preventing bacterial drug resistance. Host gene expression profiling as an approach to infection holds great potential in assisting early infection. To improve the precision diagnosis, we developed InfectDiagno, a rank-based ensemble machine learning algorithm via host patterns. Eleven data sets were used training method development, InfectDiagno was optimized by multi-cohort samples. Nine independent...
Abstract African wild rice Oryza longistaminata , one of the eight AA‐ genome species in genus possesses highly valued traits, such as rhizomatousness for perennial breeding, strong tolerance to biotic and abiotic stresses, high biomass production on poor soils. To obtain high‐quality reference O. we employed a hybrid assembly approach through incorporating Illumina PacBio sequencing datasets. The final comprised only 107 scaffolds was approximately ∼363.5 Mb, representing ∼92.7% estimated...
A Gram-negative, aerobic, neutrophilic, rod-shaped bacterium, designated strain CN85(T), was isolated from a sediment sample collected the East China Sea and subjected to polyphasic taxonomic characterization. This isolate grew in presence of 0.5-6.0 % (w/v) NaCl at 20-40 degrees C; optimum growth observed with 3 35 C. Chemotaxonomic analysis showed that Q-8 predominant respiratory quinone iso-C(15 : 0), iso-C(11 0) 3-OH, iso-C(17 1)omega9c, C(16 were major fatty acids. The G+C content...
Abstract Panax notoginseng is one of the most widely used traditional Chinese herbs with particularly valued roots. Triterpenoid saponins are mainly specialized secondary metabolites, which medically act as bioactive components. Knowledge ginsenoside biosynthesis in P. , great importance industrial and genetic breeding program, remains largely undetermined. Here we combined single molecular real time (SMRT) Second-Generation Sequencing (SGS) technologies to generate a widespread...
Despite having been extensively studied, it remains largely unclear why humans bear a particularly high risk of cancer. The antagonistic pleiotropy hypothesis predicts that primate-specific genes (PSGs) tend to promote tumorigenesis, while the molecular atavism PSGs involved in tumors may represent recently derived duplicates unicellular genes. However, these predictions have not tested.
The Professional Committee of Microbiology the National Pharmacopoeia Commission organized drafting Technical Guidelines for Microbial Whole Genome Sequencing (WGS), aiming to standardize method process and technical indicators microbial WGS ensure accuracy sequencing identification. On basis Guidelines, we developed an integrated identification source tracking (MIST) system, which could meet needs contamination investigation in food drug quality control. MIST integrates three analysis...
Heterophylly is regard as an important adaptive mechanism in response to different environments within plants. However, the genetic mechanisms responsible for heterophylly woody plants are still poorly understood. Herein, divergence of heterophyllous leaves was investigated at morphogenesis and using microdissection physiological indexes paper mulberry, basis further revealed combined with genome-wide association study (GWAS), transcriptome analysis weighted gene coexpression network...
Studies in the Xenopus model system have provided considerable insight into developmental role of intracellular Ca2+ signals produced by activation IP3Rs (inositol 1,4,5-trisphosphate receptors). However, unlike mammalian systems where three IP3R subtypes been well characterized, our molecular understanding that underpin signalling during embryogenesis relate solely to original characterization ‘Xenopus IP3R’ cloned and purified from laevis oocytes several years ago. In present study, we...
We report complete nucleotide sequence of the Panax notoginseng chloroplast genome using next-generation sequencing technology. The consists 156 324 bp containing a pair inverted repeats (IRs) 26 105 bp, which was separated by large single-copy region and small 86 082 18 032 respectively. P. cp encodes 114 unigenes (80 protein-coding genes, 4 rRNA 30 tRNA genes), in are duplicated IR regions. genic regions account for 51.1% whole genome, GC content plastome 38.1%. A phylogenomic analysis 10...