A5065826467- Liver Disease Diagnosis and Treatment
- Gut microbiota and health
- Diet and metabolism studies
- Helicobacter pylori-related gastroenterology studies
- Diet, Metabolism, and Disease
- Nutrition, Genetics, and Disease
- Cardiovascular Disease and Adiposity
- Healthcare Systems and Public Health
- Pharmacological Effects of Natural Compounds
- Clostridium difficile and Clostridium perfringens research
- Nutritional Studies and Diet
- Digestive system and related health
- Gastrointestinal motility and disorders
- Pancreatitis Pathology and Treatment
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Microscopic Colitis
- Gastroesophageal reflux and treatments
- Diabetes and associated disorders
- Gastric Cancer Management and Outcomes
- Veterinary medicine and infectious diseases
- Apelin-related biomedical research
- Diabetes Treatment and Management
- Folate and B Vitamins Research
- Pharmacology and Obesity Treatment
L.T. Malaya National Therapy Institute of the National Academy of Medical Sciences of Ukraine
2015-2025
Kharkiv National Medical University
2012
The effect of continuing vs withdrawing treatment with semaglutide, a glucagon-like peptide 1 receptor agonist, on weight loss maintenance in people overweight or obesity is unknown.To compare continued once-weekly subcutaneous 2.4 mg, switch to placebo for (both lifestyle intervention) adults after 20-week run-in semaglutide titrated mg weekly.Randomized, double-blind, 68-week phase 3a withdrawal study conducted at 73 sites 10 countries from June 2018 March 2020 body mass index least 30 (or...
Glycerol phenylbutyrate (GPB) lowers ammonia by providing an alternate pathway to urea for waste nitrogen excretion in the form of phenylacetyl glutamine, which is excreted urine. This randomized, double-blind, placebo-controlled phase II trial enrolled 178 patients with cirrhosis, including 59 already taking rifaximin, who had experienced two or more hepatic encephalopathy (HE) events previous 6 months. The primary endpoint was proportion HE events. Other endpoints included time first...
Bismuth quadruple therapies (BQTs) including bismuth, a proton pump inhibitor (PPI) and two antibiotics have been shown to be highly effective for treating
Aim: To evaluate the prescriptions patterns, effectiveness, and safety of adding probiotics to Helicobacter pylori eradication therapy, in Europe. Design: International, prospective, non-interventional registry clinical practice European gastroenterologists. Data were collected quality reviewed until March 2021 at AEG-REDCap. The effectiveness was evaluated by modified intention-to-treat analysis, differentiating geographic areas. Adverse events (AE) categorized as mild, moderate, severe....
Objective — to determine butyrate metabolism (via the level of butyrateproducing bacteria) and assess qualitative quantitative changes in intestinal microbiota composition at major phyla patients with nonalcoholic fatty liver disease (NAFLD) under various stress factors during wartime. Materials methods. The study included 114 NAFLD metabolic disorders. 60 were examined wartime, 54 assessed prewar period. Solidphase enzymelinked immunosorbent assay using reagents «InsulinELISA»...
Low physical activity, high‑calorie diet due to the formation of a positive energy balance contribute development overweight and obesity and, according forecasts, their prevalence will increase rapidly worldwide. Excess adipose tissue has negative health consequences (the greatest risks relate visceral tissue) — type 2 diabetes, cardiovascular diseases, chronic kidney disease, oncology, diseases musculoskeletal system negatively affects psycho‑emotional social health. Therefore, problem...
ABSTRACT Background The influence of indications for Helicobacter pylori investigation on prescriptions and effectiveness is unknown. aim the study was to assess impact H. prescriptions, effectiveness, compliance, tolerance. Methods International, prospective, non‐interventional registry management infection by European gastroenterologists (Hp‐EuReg). Treatment‐näive patients registered from 2013 2023 at e‐CRF AEG‐REDCap were analyzed. assessed modified intention‐to‐treat analysis. Results...
The review of the history therapy is dedicated to outstanding scientists, jubilarians year 2024: L. T. Academicians Mala (1919—2003), V. Frolkis (1924—1999) and O. Korkushko (1929—2024). Their achievements considered in field cardiology, therapy, age‑related physiology, clinical gerontology, attention emphasized on their professional cooperation, personal relationships, fruitful activities related formation Academy Medical Sciences Ukraine, State Prize Ukraine Science Technology, jointly...
The article presents research data on the association of nonalcoholic fatty liver disease (NAFLD) with cardiovascular diseases, which determine main severity prognosis in this patients’ population. This indicates that NAFLD should be considered as a significant risk factor for fatal and nonfatal events due to its close relationship development atherosclerosis coronary heart disease. It is emphasized such factors insulin resistance dyslipidemia, has pronounced atherogenic nature, pro‑oxidant...
The aim: To study the state of intestinal microbiota (ІМ) in patients with Nonalcoholic fatty liver disease (NAFLD) and to determine changes its composition at level basic phylotypes.Materials methods: included 114 NAFLD metabolic disorders 64 control group. Determination ІМ major phylotypes was performed by identifying total bacterial DNA Bacteroidetes, Firmicutes Actinobacteria quantitative polymerase chain reaction (PCR) real time (qRT-PCR) using universal primers for 16S rRNA gene...
Objective — to analyze the risk factors of disease course, evaluate metabolic and biochemical markers inflammation in patients with non‑alcoholic fatty liver (NAFLD) who were affected by stress during martial law. Materials methods. Examinations involved 42 NAFLD military operations, 20 subjects control group. Investigations included questionnaire survey, determination quantitative qualitative state visceral lipid tissue (VLT) use OMRON BF‑511 body composition monitor scales. Levels...
Nonalcoholic fatty liver disease (NAFLD) is the most common that can progress to fibrosis, cirrhosis, and cancer. The interacts with other organs by releasing hepatokines — hormone‑like proteins are mainly secreted hepatocytes. first identified hepatokine regulates human metabolic homeostasis through multiorgan interactions fetuin‑A a multifunctional α2‑glycoprotein belongs family of cystatin protease inhibitors. Experimental clinical studies have demonstrated significant increase in...
Kontext a cíl výzkumu: Nealkoholické ztukovatění jater (nonalcoholic fatty liver disease, NAFLD) má závažné ekonomické dopady na zdravotnictví celosvětově Ukrajině obzvláště. Hlavní příčinou mortality pacientů s NAFLD jsou kardiovaskulární onemocnění (KVO). Za potenciální mechanismus rozvoje ischemické choroby srdeční (ICHS) u lze považovat změny ve složení střevní mikrobioty. Cílem našeho výzkumu bylo zjistit koncentrací hlavních fylotypů mikrobioty, kmenů Bacteroidetes, Firmicutes...
The resent investigations demonstrate the key role of human microbiome in formation homeostasis, highlight microbiota effects on a immune system, its development and physiology, including organo- morphogenesis, as well metabolism. According to current data obtained with use metagenomic, metatranscriptomic, metaproteomic metabolic approaches, number microorganisms that inhabit body is 10 times greater than cells body. total contains more 5 million genes, which ten genome. billions bacteria...
Objective — to assess the state of affairs in diagnosis and treatment Helicobacter pylori infection Ukraine their conformity with modern international recommendations.Materials methods. The performed analysis included data 500 patients H. pylori-associated gastrointestinal diseases, registered period year 2013 26.10.2018 Ukrainian Registry «gfadeenko» within frameworks multicentre prospective trial Hp-EuReg UKRAINE, initiated by European Group on investigation microbiota (EHMSG). All were...
Objective — to study the nature of changes in carbohydrate and lipid metabolism, depending on distribution activity visceral adipose tissue (VAT), degree liver steatosis patients with nonalcoholic fatty disease (NAFLD) against background a metabolic syndrome (MS).Materials methods. Were examined 62 NAFLD: 26 men (40 %) 36 women (60 %). The mean age was 57.3 ± 9.2 years. control group consisted 30 healthy donors same males females. All were assessed parameters an objective examination...
Coronavirus disease 2019 (COVID‑19) began in December Wuhan, Hubei, People's Republic of China. On March 11, 2020, COVID‑19 was recognized by the World Conservation Organization (WHO) as a pandemic. As May 31, more than 6 million cases were recorded almost all countries. The etiological factor is new coronavirus severe acute respiratory syndrome‑2 (SARS‑CoV‑2), which belongs to genus β‑coronaviruses, well other already known pathogens this family — SARS and Middle Eastern syndrome (MERS)....
The aim: To analyze the status of Gut microbiota (GM) at level main phylotypes in patients with NAFLD, depending on body mass index (BMI) and gender comparison a group practically healthy individuals. Materials methods: study involved 120 who were divided into two groups BMI control containing 20 Results: In NAFLD comorbid obesity, statistically significant increase relative amount Firmicutes (52.12 [42.38; 67.39]%) Firmicutes/Bacteroidetes ratio (3.75 [1.7; 9.5]) against background decrease...
The paper presents analysis of publications devoted to the use cytoprotectant Doctovit at acid‑dependent gastroduodenal diseases and prospects its inflammatory erosive injuries esophagus, stomach duodenum. A pathogenetic substantiation expediency using (a complex vitamins U (methylmethionine) B5 (dexpanthenol)) is presented for cases ulcerative (Helicobacter pylori‑associated) lesions NSAID‑gastropathy, as well preservation changes in gastric mucosa after antihelicobacter therapy...
Objective — to determine the role of adding tetracycline bismuth‑containing quadrotherapy in increasing eradication effectiveness. Helicobacter pylori (H. pylori) is recognized as main pathogen humankind more than 40 years ago. Despite treatment H. positive individuals and reduction infection transmission populations with improved socio‑economic standards living, it remains most widespread bacterial humankind, infecting almost half Earth’s population. As a result, this continues be...