Objective — to determine butyrate metabolism (via the level of butyrate­­producing bacteria) and assess qualitative quantitative changes in intestinal microbiota composition at major phyla patients with non­­alcoholic fatty liver disease (NAFLD) under various stress factors during wartime. Materials methods. The study included 114 NAFLD metabolic disorders. 60 were examined wartime, 54 assessed pre­­war period. Solid­­phase enzyme­­linked immunosorbent assay using reagents «Insulin­­ELISA»...

The impact of fatty liver disease on public health and the economics has raised an increased interest in studying this disease. In year 2020, experts international consensus group proposed to rename non‑alcoholic (NAFLD) metabolic dysfunction‑associated (MAFLD), change diagnostic criteria for disease, because they did not correspond recent concepts. previous name NAFLD fully reflect pathogenesis which excessive attention was paid alcohol, important risk factors that significantly affect...

The aim: To study the state of intestinal microbiota (ІМ) in patients with Nonalcoholic fatty liver disease (NAFLD) and to determine changes its composition at level basic phylotypes.Materials methods: included 114 NAFLD metabolic disorders 64 control group. Determination ІМ major phylotypes was performed by identifying total bacterial DNA Bacteroidetes, Firmicutes Actinobacteria quantitative polymerase chain reaction (PCR) real time (qRT-PCR) using universal primers for 16S rRNA gene...

Objective — to analyze the risk factors of disease course, evaluate metabolic and biochemical markers inflammation in patients with non‑alcoholic fatty liver (NAFLD) who were affected by stress during martial law. Materials methods. Examinations involved 42 NAFLD military operations, 20 subjects control group. Investigations included questionnaire survey, determination quantitative qualitative state visceral lipid tissue (VLT) use OMRON BF‑511 body composition monitor scales. Levels...

Nonalcoholic fatty liver disease (NAFLD) is the most common that can progress to fibrosis, cirrhosis, and cancer. The interacts with other organs by releasing hepatokines — hormone‑like proteins are mainly secreted hepatocytes. first identified hepatokine regulates human metabolic homeostasis through multiorgan interactions fetuin‑A a multifunctional α2‑glycoprotein belongs family of cystatin protease inhibitors. Experimental clinical studies have demonstrated significant increase in...

Non-alcoholic fatty liver disease (NAFLD) is a characterized by steatosis and the ability to progress more serious pathological conditions, including non-alcoholic steatohepatitis (NASH), fibrosis cirrhosis of liver. The progression inflammatory process, activation fibrogenesis collagen deposition cause process create prerequisites for occurrence liver, hepatocellular carcinoma. appearance considered most important histological change that determines subsequent course NASH. puncture biopsy...

Objective — to study the nature of changes in carbohydrate and lipid metabolism, depending on distribution activity visceral adipose tissue (VAT), degree liver steatosis patients with nonalcoholic fatty disease (NAFLD) against background a metabolic syndrome (MS).Materials methods. Were examined 62 NAFLD: 26 men (40 %) 36 women (60 %). The mean age was 57.3 ± 9.2 years. control group consisted 30 healthy donors same males females. All were assessed parameters an objective examination...

Nonalcoholic fatty liver disease (NAFLD) is a common with steadily increasing incidence. Clinical and experimental studies of recent years testify to the key role intestinal microbiota (IM) imbalance in development progression NAFLD. Objective — determine effects combined therapy on state prevent Materials methods. Investigation involved 108 patients NAFLD metabolic disorders 30 people control group, who were examined basis Department Gastroenterology Therapy, out‑patient ward L. T. Malaya...

Objective — to analyze levels of chronic stress hormones in patients with non‑alcoholic fatty liver disease (NAFLD), who were exposed psychogenic factors wartime. Materials and methods. Examinations involved 88 NAFLD, form them 38 subject examined the pre‑war period (comparison group), 50 under influence during hostilities (main group). Control group consisted 20 practically healthy subjects. Patients’ groups matched by age. The main 28 men 22 women, comparison included 17 21 women. mean age...

Objective — to determine changes in the qualitative and quantitative composition of intestinal microbiota (IM) at level main phyla patients with non‑alcoholic fatty liver disease (NAFLD) who were affected by various negative stress factors war period. Materials methods. The study involved 114 NAFLD metabolic disorders, including 54 pre‑war period (comparison group) 60 that exposed (main group). Both groups comparable terms gender age. content chronic hormones brain‑derived neurotrophic...

Non-alcoholic fatty liver disease (NAFLD) is the worldwide most common disease. The modern pathogenesis of NAFLD associated with disorders in regulation cellular processes by microRNAs at post-transcriptional level, particular, miRNA-34a and miRNA-122.Objective — to study levels miRNA-34a, microRNA-122 expression determine their role development progression combined metabolic syndrome.Materials methods. examinations involved 78 patients components syndrome. control group consisted 30 healthy...

Nonalcoholic fatty liver disease (NAFLD) pathogenesis displays a close relation with intestinal dysbiosis. Thus, the aim of this study was to investigate microbiota (IM) composition and determine correlation changes in its main phylotypes amount activity adipose tissue NAFLD patients. Methods. The prospective enrolled 114 patients metabolic disorders 30 healthy subjects as control group. Along routine examination, authors assessed by identifying total bacterial DNA Bacteroidetes, Firmicutes,...

The functional diseases of gastrointestinal tract, including irritable bowel syndrome and constipation, are great interest for physicians various specialties. Resent investigations enabled to reveal the new etiological factors mechanisms development these diseases. Rome criteria have been developed as a standard definition chronic constipation; first version was published in year 1994. Currently 4th revision Rome, adopted 2016, is used. understanding constipation at leads changes approaches...

Objective — to determine the features of quantitative composition intestinal microbiota in patients with non‑alcoholic fatty liver disease (NAFLD) and their relationship metabolic parameters.Materials methods. The study included 114 NAFLD (42 men (36.84 %) 72 women (63.16 %), aged 51.52 [47.31; 58.22] years). All underwent a determination colon Microbiota by real‑time PCR using Colonoflor‑16 test system, manufactured Alfalab (RF).Results. In NAFLD, following trends have been revealed:...

Цель работы — изучить роль адипокинов (лептин, адипонектин) и маркеров воспаления в развитии гастроэзофагеальной рефлюксной болезни (ГЭРБ) при ожирении. В исследование были включены 92 пациента, из них 48 пациентов с ГЭРБ 44 ожирением. Концентрация лептина была значительно выше у больных ожирением по сравнению пациентами ГЭРБ. Рост ИМТ провоцирует развитие эзофагитов более высоких градаций. Изменения слизистой оболочки пищевода на фоне ожирения сопровождаются повышением уровня С-реактивного...

Introduction. Currently there are few and contradictory data concerning the influence of intestinal microbiota (IM) disturbances on nature severity inflammatory processes in liver tissue, role microbial metabolites activation steatosis fibrosis patients with non-alcoholic fatty disease (NAFLD). The aim study. To clarify microbiota, endotoxemia systemic inflammation development progression nonalcoholic disease. Materials methods. 108 NAFLD were examined, control group included 30 people....

Objective — to detect possible association of polymorphisms the Pro12Ala PPARG2 gene (rs1801282) and ADRB3 (rs4994) with a degree fatty liver metabolic disorders in patients NAFLD.Materials methods. The study involved 78 (43 men 35 women mean age 42.0 ± 5.2 years NAFLD 30 subjects control group without signs damaged (13 27 women, 38.0 7.1 years. determination genes was carried out by real-time polymerase chain reaction (PCR) method.Results. results demonstrated predominance CC homozygotes...

MicroRNAs (miRNAs) are the small non-coding RNAs that regulate multiple physiological and pathological processes through modulation of gene expression at post-transcriptional level. The role miRNAs has been proved in development pathogenesis liver disease, specifically, non-alcoholic fatty disease (NAFLD). possibility using micro-RNA as diagnostic markers discussed. article consists summarizes data literature investigating NAFLD. potential use biomarkers is Among a big number miRNAs,...

Acute and chronic diarrhea are severe clinical syndromes that can be observed in various diseases of internal organs. The unidentified cause syndrome hampers administration the etiotropic therapy. effective timely treatment promotes improvement quality life prevents complications’ development. Smectalia is a new form diosmectite, an antidiarrheal drug used to treat infectious inflammatory bowel diseases, as well diarrheal etiologies. Owing its spatial structure high plastic viscosity,...

Objective — to investigate endotoxin levels and assess the relationship between endotoxemia metabolic parameters degree of steatosis fibrosis in patients with non‑alcoholic fatty liver disease (NAFLD) against background syndrome (MS).
 Materials methods. The study included 68 NAFLD disorders 20 people control group. Women prevailed both investigational groups, mean age was 49.34 ± 10.8 years. All underwent evaluation their anthropometric parameters, investigation body composition...