A5040957326- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- RNA Interference and Gene Delivery
- Viral-associated cancers and disorders
- Chemotherapy-induced organ toxicity mitigation
- Microscopic Colitis
- Pomegranate: compositions and health benefits
- Acute Lymphoblastic Leukemia research
- HIV Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Sirtuins and Resveratrol in Medicine
- Animal Genetics and Reproduction
- Chronic Lymphocytic Leukemia Research
- Tea Polyphenols and Effects
- Galectins and Cancer Biology
- Helicobacter pylori-related gastroenterology studies
- Paraoxonase enzyme and polymorphisms
- Animal Disease Management and Epidemiology
- Virus-based gene therapy research
- Mitochondrial Function and Pathology
- COVID-19 Impact on Reproduction
- T-cell and B-cell Immunology
- Nanoparticles: synthesis and applications
- Cytomegalovirus and herpesvirus research
King Abdulaziz University
2022-2025
National Research Centre
2021
Cadi Ayyad University
2012
The nonclassic clinical presentation of celiac disease (CD) becomes increasingly common in physician's daily practice, which requires an awareness its many faces with atypical, silent, and latent forms. Besides the genetic background (HLA DQ2/DQ8) disease, other non-HLA genes are now notably reported a probable association to atypical availability high-sensitive specific serologic tests such as antitissue transglutuminase, antiendomysium, more recent antideamidated, gliadin peptide...
Background: The mammalian NAD-dependent deacetylase sirtuin-1 family (named also silent information regulator or SIRT family, where NAD stands for “nicotinamide adenine dinucleotide” (NAD)) appears to have a dual role in several human cancers by modulating cell proliferation and death. This study examines how SIRT1 protein levels correlate with clinicopathological characteristics survival outcomes patients breast cancer. Methods: A total of 407 BC formalin-fixed paraffin-embedded (FFPE)...
Dendritic cells (DCs) are major contributors to generating an effective immune response due their ability present antigens T cells. Recently, nanoparticles have been widely used in different medical applications, such as drug-delivery systems, enhance the function of impaired Objectives: This research aims develop antitumor DC-based vaccine by adsorption chitosan-nanoparticles (CH-NPs) onto DCs. Methods: Undifferentiated mouse bone marrow progenitor were differentiated into mature DCs using...
Diabetic nephropathy is a significant medical condition that arises from elevated blood sugar levels associated with both type I and II diabetes. Recent research has indicated ellagic acid (EA), either alone or in combination other medications, can provide anti-diabetic benefits. This study aimed to explore the effects of EA nanoformulations (EN) on induced by diabetes rats, while also investigating underlying mechanisms at play. To induce diabetes, rats were fed high-fat diet for four...
Human Immunodeficiency Virus (HIV) is a significant threat to public health. HIV genotyping and antiretroviral resistance testing may have contributed improved non-treated management. Immune markers might assist HIV-1 diagnosis drug-resistant variant identification. immunogenicity molecular characteristics of drug are evaluated in 56 treatment-naive patients. DNA sequencing retroviral identified genotypes. 55.4% patients were susceptible protease inhibitors (PI), nucleoside reverse...
Breast cancer (BC) is the most common in women worldwide, with 2.3 million cases recorded 2020. Despite improvements treatment, patients BC still succumb to disease, due regional and distant metastases when diagnosed at later stages. Several immune checkpoint inhibitors have been approved for based on their expression role maintaining immunosurveillance against tumors. The present study aimed evaluate of 12 checkpoints BC, assess as diagnostic therapeutic markers. Expression levels were...
Colorectal cancer (CRC) is a malignancy that manifests in serial stages and has been observed to have an escalating incidence modern societies, causing significant global health problem. The development of CRC influenced by various exogenous factors, including lifestyle, diet, nutrition, environment, microbiota, can affect host cells, immune cells. Various dysfunctions recognized patients with at different this disease. signature microbiota the CRC-inflammation related obesity, reactive such...
Factorial design is a simple, yet elegant method to investigate the effect of multiple factors and their interaction on specific response simultaneously. Hence, this type study reaches best optimization conditions process. Although between variables widely prevalent in cell culture procedures, factorial per se infrequently utilized improving output. Therefore, we aim optimize experimental for generating mature bone marrow-derived dendritic cells (BMDCs). Two different were investigated,...
Herpesvirus entry mediator (HVEM) is a molecular switch that can modulate immune responses against cancer. The significance of HVEM as an checkpoint target and potential prognostic biomarker in malignancies still controversial. This study aims to determine whether with inhibitory effects on anti-tumor CD4+ T cell vitro gene expression dysregulated patients acute lymphocytic leukemia (ALL). tumor lines peripheral blood mononuclear cells (PBMCs) from ALL healthy controls was measured using...
In virotherapy, cancer cells are eradicated via viral infection, replication, and dissemination (oncolysis). Background: This study aims to evaluate the oncolytic potential of Newcastle disease virus (NDV) against colon explore immune response associated with its therapeutic effects. Methods: NDV was tested for in cell lines using MTT assays apoptosis assessments. Tumor-induced mice were treated NDV, tumor lysate (TCL), or a combination both. After euthanasia murine subjects, an assessment...
B-cell acute lymphoblastic leukemia (B-ALL) accounts for 85% of all childhood ALL. Malignancies exhaust T and B cells, resulting in an increased expression immune checkpoint receptors (ICRs), such as T-cell immunoglobulin mucin domain 3 (TIM-3). TIM-3 has been found to be dysregulated different types cancer. However, there is a lack rigorous studies on the B-ALL. The current study aimed measure at gene protein levels evaluate potential biomarker A total 28 subjects were recruited between...
Breast cancer is the most frequent kind of invasive in women. Biomarker monitoring and prognosis provide outstanding clinical information that may be employed to battle various cancers. This study aimed examine a variety biomarkers utilizing multiplex bead array. BTLA, CD27, CD28, TIM-3, HVEM, CD40, LAG-3, TLR-2, PD-1, CD80, CD86, PDL-1, PDL-2, ICOS are common biomarker checkpoint proteins found selective panel. panel examined research group 59 patients with BC
Bluetongue disease (BT) is a notifiable arboviral affecting ruminants causing severe economic losses worldwide.The BTV can infect nearly all and largely transmitted via biting midge (Culicoides spp.) among other arthropods.Bluetongue virus (BTV) non-enveloped, spherical double-stranded RNA virus, with 3 concentric protein shells, belonging to genus Orbivirus family Reoviridae.The codes for 5 non-structural proteins (NS1, NS2, NS3/NS3A, NS4 NS5) 7 structural (VP1-VP7) (Stewart et al., 2015;...
Classification of the causative agentAfrican horse sickness (AHS) is caused by a virus family Reoviridae, genus Orbivirus.There are 9 antigenically distinct serotypes AHS (AHSV) identified neutralisation, but some crossreaction has been observed between 1 and2, 3 and7, 5 and8, and6 and9.No cross-reactions with other known orbiviruses have observed. Resistance to physical and chemical actionTemperature:AHSV relatively heat stable, it not inactivated heating in citrated plasma at 55-75°C for...
T HE current Study intends to study the mitochondrial genome proteins specifically focusing on distribution of intrinsically disordered regions within these proteins.The UniProt were employed obtain amino acid sequences proteins.Next, obtained studied identify their unique features.We used PONDR VSL2 algorithm assess for any order or disorder.According results, expected depict unexpected levels intrinsic disorder.The results also indicated possibility presence 7 disorder mostly found be...