A5056053548- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis and Biological Evaluation
- Quinazolinone synthesis and applications
- Bioactive Compounds and Antitumor Agents
- Reproductive System and Pregnancy
- Mathematical and Theoretical Epidemiology and Ecology Models
- Malaria Research and Control
- Mosquito-borne diseases and control
- Pharmacological Effects of Natural Compounds
- Nigella sativa pharmacological applications
- Pomegranate: compositions and health benefits
- Viral Infections and Outbreaks Research
- Banana Cultivation and Research
- Antibiotic Use and Resistance
- Viral Infections and Vectors
- RNA Interference and Gene Delivery
- Biofuel production and bioconversion
- Disaster Response and Management
- Glycosylation and Glycoproteins Research
- Adolescent Sexual and Reproductive Health
- Carbon and Quantum Dots Applications
- Pregnancy and Medication Impact
- Parasites and Host Interactions
- Vibrio bacteria research studies
- Fractional Differential Equations Solutions
King Abdulaziz University
2023-2025
Herbal medicinal plants have been used for centuries in traditional medicine, and it is interesting to see how modern research has identified the active compounds responsible their therapeutic effects. The green synthesis of silver nanoparticles using herbal plants, such as Swertia chirata, particularly noteworthy due its antimicrobial properties. In current study, chirata plant was collected first time from region Murree, Punjab, Pakistan. After collection, extracts were prepared different...
Diabetes mellitus (DM) is a metabolic disorder with notable increase in global incidence recent years. Individuals diagnosed diabetes are at an elevated risk of morbidity and mortality compared the general population. For several years, potential phytochemicals as anti-inflammatory agents to improve healing diabetic wounds has been under investigation. Rutin, flavonoid, particularly promising candidate for use wound healing. Our study aims investigate impact topical application rutin...
<p>In this study, we introduce a novel reaction-diffusion epidemic model to analyze the transmission dynamics of hepatitis B virus (HBV). The captured interactions between five population groups: Susceptible individuals, those in latent stage, acutely infected chronically and who have recovered, while considering spatial movement these groups. Chronic HBV infection contributes severe liver diseases such as cirrhosis hepatocellular carcinoma. It is also major cause long-term disability...
Methicillin-resistant Staphylococcus aureus (MRSA) is a major pathogen causing infections ranging from skin disorders to severe conditions like infective endocarditis. Its evolving resistance, including resistance β-lactams and last-resort antibiotics, such as vancomycin, daptomycin, linezolid, necessitates alternative therapies. This study investigates the synergistic efficacy of vancomycin 3-hydrazinoquinoxaline-2-thiol (3HL) against 23 clinical MRSA isolates. Susceptibility testing was...
This study examines the transmission with hearing loss disability risk of Lassa fever using a gender-spesific model based on nonlinear differential equations. The human population is divided into susceptible females, infected males, and recovered humans. Empirical data from LASV-endemic regions are employed for rigorous validation parameter estimation, ensuring alignment observed cases. basic reproduction number \( R_0 \), obtained next-generation matrix approach, functions as necessary...
This work presents a novel fractional reaction-diffusion model to analyze the spatio-temporal dynamics of poliovirus transmission. Polio, highly contagious viral infection that primarily affects children under five and can lead permanent disability, spreads through fecal-oral airborne transmission, often exacerbated by poor sanitation environmental conditions. Traditional polio models, predominantly based on ordinary differential equations (ODEs), have assumed spatial uniformity an...
Border malaria is a major obstacle for the elimination in Saudi Arabia. Today, southern border of Arabia region where cases are resurging, and control dwindling mainly due to humanitarian crisis conflict Yemen. This study analyses current epidemiology along from 2015 2018.All reported maintained by centres Aledabi Baish, Jazan Province, Arabia, 2018 were analysed examine epidemiological changes over time. Pearson's Chi-Square test differences was utilized assess between characteristics...
Livelihood activities and human movements participate in the epidemiology of vector-borne diseases influence malaria risk elimination settings. In Saudi Arabia, where transmission intensity varies geographically, it is vital to understand components driving within specific areas. addition, shared social, behavioural, occupational characteristics communities may provoke infection. This study aims relationship between mobility, livelihood activities, infection border region Jazan facilitate...
Potato peel wastes are generated in high quantities from potato processing industries. They pollutants to the environment, and they release greenhouse gases into atmosphere. The present study assessed potentiality of hydrolyzing by amylase-producing fungi improve biogas generation peels through anaerobic digestion process. Different fungal isolates were screened for amylase production on wastes, highest producer was selected optimizing efficacy producing amylases efficiently allow conversion...
Mycobacterium tuberculosis is responsible for (TB) all over the world. Despite tremendous advancements in biomedical research, new treatment approaches, and preventive measures, TB incidence rates continue to ascend. The herbaceous plant Acalypha indica, also known as Indian Nettle, belongs Euphorbiaceae family one of most important sources medicines pharmaceuticals medical therapy a range ailments. However, precise molecular mechanism its therapeutic action still unknown. In this study, an...
The activity of UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE) is essential for the biosynthesis sialic acid, which involved in cellular processes health and diseases. GNE contains an N-terminal epimerase domain a C-terminal (N-acetylmannosamine kinase, MNK). Mutations protein led to hypoactivity enzyme cause sialurea or autosomal recessive inclusion body myopathy/Nonaka myopathy. Here, we used all-atom molecular dynamics (MD) simulations comprehend folding, conformational stability MNK...
Objective: To investigate the gastroprotective influence of 2,3-Dichloro-6-(trifluoromethoxy) quinoxaline in a rat model indomethacininducedgastric ulcers. Methods: Thirty male Wistar rats were randomly divided into five groups (n = 6) as follows: Group 1 (control), 2 (indomethacin only, 30 mg/kg), 3 and quinoxaline, 4 with 60 5 esomeprazole, mg/kg). The efficacy mitigating gastric ulcers induced by indomethacin was evaluated based on morphology, histopathology, inflammatory biomarkers....
These days carbon dots have been developed for multiple biomedical applications. In the current study, transfection potential of synthesized from single biopolymers such as chitosan, PEI-2kDa, and PEI-25kDa (CS-CDs, PEI2-CDs, PEI25-CDs) by combining two (CP2-CDs CP25-CDs) through a bottom-up approach investigated. The characterization studies revealed successful synthesis fluorescent, positively charged <20 nm in size. Synthesized formed stable complex with plasmid DNA (EGFP-N1) miRNA-153...
The presence of COVID-19 antibodies in the maternal circulation is assumed to be protective for newborns against SARS-CoV-2 infection. We investigated whether crossed transplacental barrier and there was any difference hematological parameters neonates born mothers who recovered from during pregnancy. cross-sectional study conducted at Saidu Group Teaching Hospitals, located Swat, Khyber Pakhtunkhwa. After obtaining written informed consent, 115 healthy, unvaccinated mother-neonate dyads...
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Introduction: Candida is the primary cause of invasive fungal disease, candidiasis, especially in developed nations. The increasing resistance observed multiple antibiotics, coupled with prolonged process creating new antibiotics from ground up, emphasizes urgent requirement for innovative methods and compounds to combat infections. Employing a treatment strategy that combines can improve efficacy, broaden spectrum targeted fungal, reduce chances emergence. This approach shows potential...
Purpose: Parasitic infections are a primary cause of illness worldwide and public health problem. This study highlighted the prevalence intestinal parasitic (IP) their updated epidemiologic status from 2019 to 2023 at King Abdulaziz University Hospital, Jeddah, Saudi Arabia. Patients Methods: A retrospective was conducted Hospital. The laboratory results, socio-demographic information, year data collection were collected hospital's parasitology laboratory. analyzed using SPSS version 26....
Bacterial infections continue to pose a significant global health threat, further intensified by the increasing prevalence of antibiotic resistance. Methicillin-resistant Staphylococcus aureus (MRSA) poses threats, especially in healthcare settings around world. Conventional treatments face some limitations due development antimicrobial resistance, emphasizing urgent need explore alternative treatment strategies. In this study, we propose potential synergistic activity thymoquinone and...
Background: This six-year retrospective study provides an in-depth analysis of the epidemiological and clinical patterns associated with Acinetobacter baumannii ( A. ) infections, focusing on age distribution, antibiotic resistance profiles, specimen types. Aim: The research examines incidence characteristics both non-Multi-Drug Resistant (non-MDR) Multi-Drug (MDR) strains by reviewing patient records from January 2016 to December 2022. Methods: Through a statistical analysis, highlights...
Gastric ulcers have been considered as a major problem worldwide. This study investigated the protective synergistic effect of novel nutrient formulation for protection and treatment indomethacin-induced gastric ulcer in rat model. 24, 8 w old male rats with body weight between 220 240 g, were divided into four groups used this study. Group 1 consists healthy controls group 2 ulcerative animals, 3 ulcerative+phytobiological (80 mg/kg) 4 omeprazole (40 mg/kg). Pre-treatment 80 mg/kg...