A5102908042- BRCA gene mutations in cancer
- Nutrition, Genetics, and Disease
- Genetic factors in colorectal cancer
- Genomic variations and chromosomal abnormalities
- Genomics and Rare Diseases
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Advanced biosensing and bioanalysis techniques
- Lipid metabolism and disorders
- RNA Interference and Gene Delivery
- Cancer-related Molecular Pathways
- DNA and Nucleic Acid Chemistry
- CRISPR and Genetic Engineering
- Cancer Cells and Metastasis
- Economic and Financial Impacts of Cancer
- Prenatal Substance Exposure Effects
- Biological Research and Disease Studies
- Plant and Fungal Interactions Research
- Head and Neck Cancer Studies
- Advances in Oncology and Radiotherapy
- Cancer, Stress, Anesthesia, and Immune Response
- Connexins and lens biology
- Colorectal and Anal Carcinomas
- Pain Management and Opioid Use
McGill University
2025
Centre international de recherche sur le cancer
2024-2025
Motamed Cancer Institute
2016-2021
Tehran University of Medical Sciences
2016-2021
Imam Khomeini Hospital
2016-2020
Islamic Azad University, Jahrom Branch
2015
Islamic Azad University North Tehran Branch
2011
Site-directed mutagenesis is a fundamental tool indispensable for protein and plasmid engineering. An important technological question how to achieve the efficiency at ideal level of 100%. Based on complementary primer pairs, QuickChange method has been widely used, but it requires significant improvements due its low frequent unwanted mutations. alternative innovative strategy utilize pairs with 3'-overhangs, this approach not fully developed. As first step towards reaching 100%, we have...
Background Alcohol is a known carcinogen, yet the evidence for an association with pancreatic cancer risk considered as limited or inconclusive by international expert panels. We examined between alcohol intake and in large consortium of prospective studies. Methods findings Population-based individual-level data was pooled from 30 cohorts across four continents, including Asia, Australia, Europe, North America. A total 2,494,432 participants without at baseline (62% women, 84% European...
Background: The International Agency for Research on Cancer (IARC) recently classified opium use as a Group 1 carcinogen. However, much remains to be studied the relation between and cancer. We designed Iranian Opium (IROPICAN) study further investigate association of cancers head neck, bladder, lung, colon rectum. In this paper, we describe rationale, design, some initial results IROPICAN Study. Methods: is multi-center case-control conducted in 10 provinces Iran. cases were all...
Abstract Scant evidence exists to support the association of opium use with head and neck cancer, limited larynx oral cavity. In a multicenter case‐control study—Iran Opium Cancer study, we recruited 633 cases squamous cell carcinoma (HNSCC) (254 lip cavity, 54 pharynx, 327 28 other subsites within neck) 3065 frequency‐matched controls from April 2016 2019. Odds ratios (ORs) for 95% confidence intervals (95% CIs) were obtained using mixed‐effects logistic regression because heterogeneity...
Baculoviral inhibitor of apoptosis repeat-containing 5 (BIRC5) gene is an that expresses in human embryonic tissues but it absent most healthy adult tissues. The copy number BIRC5 has been indicated to be highly increased tumor tissues; however, its association with the age onset breast cancer not well understood.Forty were obtained from Tumor Bank Cancer Institute, Imam Khomeini Hospital, Tehran, Iran. variation (CNV) was evaluated using Multiplex Ligation-dependent Probe Amplification...
Abstract Site‐directed mutagenesis is an essential tool in molecular biology, protein engineering, plasmid engineering and synthetic biology. While the QuickChange method has been one of most employed methods for site‐directed mutagenesis, it hindered by low efficiency frequent introduction unwanted mutations at primer sites, raising urgent need new, more efficient, reliable methods. Here, we present optimized protocol that leverages partially complementary pairs with 3’‐overhangs to improve...
Abstract Background: Preclinical, observational, and genetic epidemiological evidence implicate circulating lipids in cancer development. The role of approved emerging lipid-perturbing medications risk is unclear. Patients Methods: We employed cis-Mendelian randomization (MR) colocalization to evaluate the 5 drug targets (ANGPTL3, ANGPTL4, APOC3, CETP, PCSK9) cancers (breast, colorectal, head neck, ovarian, prostate) up 319, 661 cases 348, 078 controls. further triangulated findings using...
Introduction: Mutations occurring in the CDH1 gene elevate susceptibility to development of hereditary diffuse gastric cancer (HDGC) as well lobular breast (LBC). LBCs with germline mutations are classified hered- itary cancers, devoid any indication carcinoma. As prophylactic gastrectomy is a recommended course treatment for individuals mu- tations, it advised that genetic testing be conducted those who meet criteria established by National Comprehensive Cancer Network (NCCN). This study...
In this multi-ancestry genome-wide association study (GWAS) and fine mapping of head neck squamous cell carcinoma (HNSCC) subsites, we analysed 19,073 cases 38,857 controls identified 29 independent novel loci. We provide robust evidence that a 3' UTR variant in
Abstract Because the contribution of genetic factors to burden breast cancer is not well investigated in Iran, we aimed examine prevalence mutations susceptibility genes, BRCA1/2 and PALB2, investigate predictive potential hereditary risk criteria for testing Iranian population. Next-generation sequencing was conducted on a population consisting 299 125 patients with cancer, without testing, respectively. The pathogenic mutation frequency rate 10.7% versus 1.6% no group (P = 0.0017). None...
Hearing impairment (HI) caused by mutations in the connexin-26 gene (GJB2) accounts for majority of cases with inherited, nonsyndromic sensorineural hearing loss. Due to illegality abortion deaf fetuses Islamic countries, preimplantation genetic diagnosis (PGD) is a possible solution afflicted families have healthy offspring. This study describes first use PGD GJB2 associated non-syndromic deafness Iran. donor splicing site IVS1+1G>A mutation analysis was performed using Sanger sequencing...
Summary The aim of this study was to determine the frequency enterotoxigenic and enteroaggregative strains Escherichia coli in chicken carcasses by polymerase chain reaction (PCR). In 63 E. were isolated from 110 samples during processing after chilling poultry slaughter house Shahrekord. Polymerase assays used detect presence genes encoding heat-stable enterotoxin a (STa), b (STb), heat labile toxin (LT) Enteroaggregative 1 (EAST1). Sixty three out (57.27%) contaminated with coli. Six...
Increase in the copy number of ERBB2, a Tyrosine Kinase Receptor (TKR) leads to overexpression oncogene product and consequently uncontrolled cell proliferation which has been reported different aggressive cancers with mitochondrial malfunctions. Although, amplification ERBB2 studies; however, association between changes DNA content gene is poorly understood. The relative breast cancer tumor tissues 70 patients who were referred Imam Khomeini Hospital Complex was determined using...
Abstract To date, not much study has been done to investigate the mitochondrial DNA (mtDNA) copy number as potential biomarker for opium exposure. Here, we conducted a cross‐sectional determine relative mtDNA content Quantitative real‐time PCR was performed variation across 205 individuals, including blood samples of 45 users, 41 cigarette 47 dual and 72 never users any product. We found significantly higher among opium‐only (adjusted OR: 3.21; 95% CI: [1.34, 7.66]; P = .009) 2.64; [1.15,...
Site-directed mutagenesis is a fundamental tool indispensable for protein and plasmid engineering. An important technological question how to achieve the efficiency at ideal level of 100%. Based on complementary primer pairs, QuickChange method has been widely used, but it requires significant improvements due its low frequent unwanted mutations. alternative innovative strategy utilize pairs with 3-prime overhangs, this approach not fully developed. As first step towards reaching 100%, we...
Background: Preclinical, observational, and genetic epidemiological evidence implicate circulating lipids in cancer development. The role of approved emerging lipid-perturbing medications risk is unclear. Patients methods: We employed cis-Mendelian randomization (MR) colocalisation to evaluate the 5 drug targets (ANGPTL3, ANGPTL4, APOC3, CETP, PCSK9) cancers (breast, colorectal, head neck, ovarian, prostate) up 319,661 cases 348,078 controls. further triangulated findings using direct...
Background: Adiposity has been associated with an increased risk of head and neck cancer (HNC). Although body mass index (BMI) inversely HNC among smokers, this is likely due to confounding. Previous Mendelian randomization (MR) studies could not fully discount causality between adiposity limited statistical power. Hence, we aimed revisit using the largest genome-wide association study (GWAS) available, which more granular data on subsites. Methods: We assessed genetically predicted effects...
Background: Identification of individuals who have a pathogenic mutation in breast cancer susceptibility genes is an important step to take advantage genetic counseling, screening, and potentially life-saving prevention strategies. Based on the National Comprehensive Cancer Network (NCCN) guideline, testing deemed suitable for patients with young age at onset, positive family history cancers, male cancer, or diagnosis multifocal triple negative cancer. Aim: Since, it not known what...