A5058117279- Epigenetics and DNA Methylation
- Neurogenesis and neuroplasticity mechanisms
- Genomics and Chromatin Dynamics
- Genetics and Neurodevelopmental Disorders
- Cancer-related Molecular Pathways
- Pluripotent Stem Cells Research
- Microtubule and mitosis dynamics
- Axon Guidance and Neuronal Signaling
- Developmental Biology and Gene Regulation
- CRISPR and Genetic Engineering
- Genomic variations and chromosomal abnormalities
- Ubiquitin and proteasome pathways
- Cerebrospinal fluid and hydrocephalus
- Nerve injury and regeneration
- Neuroscience and Neuropharmacology Research
- Planarian Biology and Electrostimulation
- Ion channel regulation and function
- Wnt/β-catenin signaling in development and cancer
- Thyroid Disorders and Treatments
- Renal and related cancers
- Biotin and Related Studies
- Growth Hormone and Insulin-like Growth Factors
- RNA Research and Splicing
- Protein Kinase Regulation and GTPase Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
Hospital Universitario La Paz
2022-2023
Universidad Autónoma de Madrid
2004-2023
Consejo Superior de Investigaciones Científicas
2004-2023
Instituto de Salud Carlos III
2018-2023
Centro de Biología Molecular Severo Ochoa
2018-2023
Hospital La Paz Institute for Health Research
2019-2023
Spanish National Cancer Research Centre
2013-2016
Universitat de València
2010-2014
Biomedical Research Networking Center on Neurodegenerative Diseases
2010-2014
Centro de Investigación Biomédica en Red
2012
Interactions of adult neural stem cells (NSCs) with supportive vasculature appear critical for their maintenance and function, although the molecular details are still under investigation. Neurotrophin (NT)-3 belongs to NT family trophic factors, best known effects in promoting neuronal survival. Here we show that NT-3 produced secreted by endothelial brain choroid plexus capillaries is required quiescence long-term NSCs mouse subependymal niche. Uptake from irrigating cerebrospinal fluid...
Abstract Several psychiatric, neurologic and neurodegenerative disorders present increased brain ventricles volume, being hydrocephalus the disease with major manifestation of ventriculomegaly caused by accumulation high amounts cerebrospinal fluid (CSF). The molecules pathomechanisms underlying cerebral ventricular enlargement are widely unknown. Kinase D interacting substrate 220 kDa ( KIDINS220) gene has been recently associated schizophrenia a novel syndrome characterized spastic...
Abstract We used proximity‐dependent biotin identification (BioID) to find proteins that potentially interact with the major glial glutamate transporter, GLT‐1, and we studied how these interactions might affect its activity. GTPase Rac1 was one protein identified, interfering GTP/GDP cycle in mixed primary rat brain cultures affected both clustering of GLT‐1 at astrocytic processes transport kinetics, increasing uptake activity low micromolar concentrations a manner dependent on effector...
Cell differentiation involves profound changes in global gene expression that often has to occur coordination with cell cycle exit. Because cyclin-dependent kinase inhibitor p27 reportedly regulates proliferation of neural progenitor cells the subependymal neurogenic niche adult mouse brain, but can also have effects on expression, we decided molecularly analyze its role neurogenesis and oligodendrogenesis. At level, show restricts residual activity after mitogen withdrawal antagonize...
Abstract In the adult mammalian brain, neural stem cells (NSCs) located in highly restricted niches sustain generation of new neurons that integrate into existing circuits. A reduction neurogenesis is linked to ageing and neurodegeneration, whereas dysregulation proliferation survival NSCs have been hypothesized be at origin glioma. Thus, unravelling molecular underpinnings regulated activation must undergo proliferate generate progeny considerable relevance. Current research has identified...
Relatively quiescent somatic stem cells support life-long cell renewal in most adult tissues. Neural the mammalian brain are restricted to two specific neurogenic niches: subgranular zone of dentate gyrus hippocampus and ventricular-subventricular (V-SVZ; also called subependymal or SEZ) walls lateral ventricles. The development vivo gene transfer strategies for populations (i.e. those brain) resulting long-term expression desired transgenes their derived progeny is a crucial tool current...
Relatively quiescent somatic stem cells support life-long cell renewal in most adult tissues. Neural the mammalian brain are restricted to two specific neurogenic niches: subgranular zone of dentate gyrus hippocampus and ventricular-subventricular (V-SVZ; also called subependymal or SEZ) walls lateral ventricles. The development vivo gene transfer strategies for populations (i.e. those brain) resulting long-term expression desired transgenes their derived progeny is a crucial tool current...
ABSTRACT In the adult mammalian brain, neural stem cells (NSCs) located in highly restricted niches sustain generation of new neurons that integrate into existing circuits. A reduction neurogenesis is linked to ageing and neurodegeneration, whereas dysregulation proliferation survival NSCs have been hypothesized be at origin glioma. Thus, unravelling molecular underpinnings regulated activation must undergo proliferate generate progeny considerable relevance. current research has identified...
Abstract Cell differentiation involves profound changes in global gene expression that often have to occur coordination with cell cycle exit. Because cyclin-dependent kinase inhibitor p27 reportedly regulates proliferation of neural progenitor cells the subependymal neurogenic niche adult mouse brain, but can also effects on expression, we decided molecularly analyze its role neurogenesis and oligodendrogenesis. At level, show restricts residual activity after mitogen withdrawal antagonize...
Abstract Cell differentiation involves profound changes in global gene expression that often have to occur coordination with cell cycle exit. Because cyclin-dependent kinase inhibitor p27 reportedly regulates proliferation of neural progenitor cells the subependymal neurogenic niche adult mouse brain, but can also effects on expression, we decided molecularly analyze its role neurogenesis and oligodendrogenesis. At level, show restricts residual activity after mitogen withdrawal antagonize...