A5050917151- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Microtubule and mitosis dynamics
- RNA modifications and cancer
- RNA Research and Splicing
- Calcium signaling and nucleotide metabolism
- Genomics and Chromatin Dynamics
- Innovative Microfluidic and Catalytic Techniques Innovation
- Autophagy in Disease and Therapy
- Hematopoietic Stem Cell Transplantation
- Genetic and Kidney Cyst Diseases
- RNA and protein synthesis mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- Cancer-related Molecular Pathways
- PARP inhibition in cancer therapy
- 3D Printing in Biomedical Research
- Cell Image Analysis Techniques
- Macrophage Migration Inhibitory Factor
- Extracellular vesicles in disease
- Genomic variations and chromosomal abnormalities
- RNA Interference and Gene Delivery
- Immune Cell Function and Interaction
- Sirtuins and Resveratrol in Medicine
Spanish National Cancer Research Centre
2023-2025
Centro de Investigación del Cáncer
2025
Instituto de Investigaciones Biomédicas Sols-Morreale
2019
Universidad Autónoma de Madrid
2019
NHS Blood and Transplant
2003
Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory responses that ultimately improve mitochondrial function, conserved anti-aging mechanism termed mitohormesis. Here, we show harmol, member beta-carbolines family with anti-depressant properties, improves function metabolic parameters, extends healthspan. Treatment harmol induces transient depolarization, strong mitophagy response, AMPK pathway both in cultured C2C12 myotubes male mouse liver, brown...
Multivesicular bodies (MVB) are endocytic compartments that enclose intraluminal vesicles (ILV) formed by inward budding from the limiting membrane of endosomes. In T lymphocytes, ILV secreted as Fas ligand-bearing, pro-apoptotic exosomes following cell receptor (TCR)-induced fusion MVB with plasma at immune synapse (IS). this study we show protein kinase C δ (PKCδ), a novel PKC isotype activated diacylglycerol (DAG), regulates TCR-controlled, polarization towards IS and exosome secretion....
The nucleolus is a membraneless organelle and an excellent stress sensor. Any changes in its architecture or composition lead to nucleolar stress, resulting cell cycle arrest interruption of ribosomal activity, critical factors aging cancer. In this study, we identified described the pivotal role RNA-binding protein (RBP) HNRNPK ribosome dynamics. We developed vitro model endogenous overexpression vivo mouse ubiquitous overexpression. These models showed disruptions translation caused...
Major histocompatibility complex (MHC) class II-associated antigen presentation involves an array of interacting molecules. CD74, the cell surface isoform MHC invariant chain, is one such molecule; its role remains poorly defined. To address this, we have employed a high-resolution single-particle imaging method for quantifying colocalization CD74 with human leukocyte (HLA)-DR molecules on fibroblast cells known their capacity to function as antigen-presenting cells. We also examined whether...
Congenital microcephaly (MCPH) is a neurodevelopmental disease associated with mutations in genes encoding proteins involved centrosomal and chromosomal dynamics during mitosis. Detailed MCPH pathogenesis at the cellular level still elusive, given diversity of lack comparative vivo studies. By generating series CRISPR/Cas9-mediated genetic KOs, we report here that - whereas defects spindle pole (ASPM, MCPH5) result mild development centrosome (CDK5RAP2, MCPH3) or centriole (CEP135, MCPH8)...
Abstract: Two main dendritic cell (DC) subsets have been described in peripheral blood, the myeloid subset or DC1 that is characterized by presence of CD11c and plasmacytoid DC2 negative for this marker. The two may perform different functions defined as immunogenic (the subset) tolerogenic subset). expression human leukocyte antigen (HLA)‐DM molecules, which act peptide editors presentation process, was studied freshly isolated DCs from blood. invariant chain (Ii), major histocompatibility...
Abstract Micro-devices and lab-on-a-chip technologies have revolutionized cell biology research, enabling a plethora of applications from single-cell sorting to organ-on-a-chip assays. However, their construction remains laborious, requiring specialized equipment trained personnel, thereby restricting accessibility laboratories. The conventional protocol for micro-device printing involves intricate steps, including master cast/mold production device fabrication, leading high costs time...
Abstract The nucleolus is a dynamic structure where ribosome subunits are produced. Indeed, nucleoli respond to any change in cellular homeostasis by altering the rate of biogenesis, thus working as stress sensor. Therefore, an imbalance biogenesis promotes changes morphology and function can evoke nucleolar response. Changes composition impair have been described stress, mechanism related aging cancer. Here, we show role RNA binding protein Hnrnpk dynamics function. ribonucleoprotein charge...