A5083993740- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Lymphoma Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Epigenetics and DNA Methylation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Histone Deacetylase Inhibitors Research
- Retinoids in leukemia and cellular processes
- Breast Implant and Reconstruction
- DNA Repair Mechanisms
- Cancer Genomics and Diagnostics
- Hematological disorders and diagnostics
- Cancer, Hypoxia, and Metabolism
- Advanced biosensing and bioanalysis techniques
- Cancer, Lipids, and Metabolism
- Sarcoma Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Histiocytic Disorders and Treatments
- Aquaculture disease management and microbiota
- Polyomavirus and related diseases
- Mesenchymal stem cell research
Instituto Nacional do Câncer
2016-2025
Instituto Nacional del Cáncer
2024
Health Research Institute of the Balearic Islands
2017-2022
Hospital Universitario Son Espases
2018-2022
Hospital Son Llatzer
2016-2022
Universitat de les Illes Balears
2017-2022
Servei de Salut de les Illes Balears
2017-2022
Research Institute of Health Sciences
2017-2022
Saint Joseph's College
2020
St. Joseph's Institute of Technology
2020
Abstract Ex vivo expansion and manipulation of human mesenchymal stem cells are important approaches to immunoregulatory regenerative cell therapies. Although these show great potential for use, issues relating their overall nature emerge as problems in the field. The need extensive quantity amplification vitro obtain sufficient numbers poses a risk accumulating genetic epigenetic abnormalities that could lead sporadic malignant transformation. In this study, we have examined derived from...
Multivesicular bodies (MVB) are endocytic compartments that enclose intraluminal vesicles (ILV) formed by inward budding from the limiting membrane of endosomes. In T lymphocytes, ILV secreted as Fas ligand-bearing, pro-apoptotic exosomes following cell receptor (TCR)-induced fusion MVB with plasma at immune synapse (IS). this study we show protein kinase C δ (PKCδ), a novel PKC isotype activated diacylglycerol (DAG), regulates TCR-controlled, polarization towards IS and exosome secretion....
An epidemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing diseases (C0VID-19) initially reported in Wuhan, China has rapidly emerged into a global pandemic affecting millions people worldwide. Molecular detection SARS-CoV-2 using reverse transcription polymerase chain reaction (RT-PCR) forms the mainstay screening, diagnosis and epidemiology disease. Since virus evolves by accumulating base substitutions, mutations viral genome could possibly affect accuracy...
The management of patients with pancreatic cancer has advanced over the last few years. We convey a multidisciplinary group experts in an attempt to stablish practical guidelines for diagnoses, staging and these patients. This paper summarizes main conclusions working group. Patients suspected ductal adenocarcinoma should be rapidly evaluated referred high-volume centers. Multidisciplinary supervision is critical proper frame treatment plan. Surgical resection together chemotherapy offers...
We studied the methylation status of p15INK4B and p16INK4A genes in 47 pediatric patients with primary MDS, its correlation subtype, role evolution MDS toward AML. Aberrant gene was detected 15 (32%), whereas only four demonstrated (8%). The frequency significantly higher RAEB RAEB-t subtypes (p < 0.003). also more frequent that characterize advanced stages disease 0.05). Evolution verified 17 (36%) patients. association clearly significant 0.008 p 0.05, respectively). These results suggest...
Most colorectal cancer (CRC) patients die as a consequence of metastasis. Mitochondrial dysfunction could enhance development and metastatic progression. We aimed to evaluate the adaptations associated with mitochondrial function in tumor tissues from stages III IV human CRC whether they ultimately be used therapeutic target (mCRC). analyzed protein levels by Western blotting enzymatic activities proteins involved function, well amount DNA (mtDNA), real-time PCR, analyzing samples non-tumor...
We analyzed cytogenetically 105 patients with hypocellular primary MDS and their clinical implications. The main chromosomal abnormalities found were del(5q)/−5, del(6q)/+6, del(7q)/−7, del(11q), del(17p). Pediatric had a higher frequency of abnormal karyotypes compared adult (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi>P</mml:mi></mml:mrow></mml:math>< 0,05). From our patients, 18% showed evolution the disease. presented in diagnosis who evolved to...
A 54-year-old woman was diagnosed with infiltrative ductal breast carcinoma. Two years after treatment, the patient developed an acute myeloid leukemia (AML) which harbored del(11q23) in 8% of blast cells. The submitted for allogeneic stem cell transplantation (aSCT) from her HLA-compatible sister. Ten months transplantation, she relapsed AML basophilic maturation characterized by CD45low CD33high, CD117+, CD13-/+, HLA Drhigh, CD123high, and CD203c+ cells lacking expression CD7, CD10, CD34,...
The purpose of this paper was to define the normal three-dimensional computed tomographic reconstruction equine cervical spine. Two millimetres thick transverse images two foals were obtained. Images provided excellent anatomic detail spine and relevant structures identified. Tridimensional can be a valuable diagnostic aid for clinical evaluation several spinal disturbances in foals. In addition, technique used as tool teaching anatomy veterinary schools.
VITAL, a phase II single-arm study, aimed to evaluate efficacy and safety of panitumumab addition 5-fluorouracil (5-FU), mitomycin-C (MMC) radiotherapy (RT) in patients with localized squamous cell carcinoma the anal canal (SCCAC). Adult, treatment-naïve SCCAC (Stage T2-T4, any N, M0) ECOG-PS ≤2, received (6 mg/kg, day 1 Q2W; 8 weeks), 5-FU (1000 mg/m2 /d, days 1-4 29-32), MMC (10 , 29) RT 45 Gy (1.8 Gy/fraction) primary tumor mesorectal, iliac inguinal lymph nodes, plus 10-15 boost dose...
Monosomy 7 arises as a recurrent chromosome aberration in donor cell leukemia after hematopoietic stem transplantation. We report new case of with monosomy following HLA-identical allogenic bone marrow transplantation for severe aplastic anemia (SAA). The male patient received graft from his sister, and was detected only the XX cells, 34 months patient's microenvironment may have played role leukemic transformation cells.
ABCB1 gene methylation analyses method to quantify status at specific sites of DNA.Here, we established HRM parameters evaluate the promoter gene.Our study is first standardize dissociation curve methylation.The association between and expression in cancer cell lines shows that this accurate reliable.
Children with Down syndrome (DS) have an enhanced risk of developing acute leukemia, the most common subtype being megakaryoblastic leukemia (AMKL). Myeloid in (ML-DS) is considered a disease distinct clinical and biological features. There are few studies focusing on clonal cytogenetic changes during evolution ML-DS. Here, we describe complex karyotype involving previously unreported set chromosomal abnormalities acquired progression ML-DS infant boy: derivative der(1)t(1;15)(q24;q23),...