A5059267876- Cancer-related Molecular Pathways
- Advanced Breast Cancer Therapies
- Phytase and its Applications
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Protein Hydrolysis and Bioactive Peptides
- Genomics and Chromatin Dynamics
- Axon Guidance and Neuronal Signaling
- HER2/EGFR in Cancer Research
- Cancer Research and Treatments
- Glioma Diagnosis and Treatment
- Wnt/β-catenin signaling in development and cancer
- Microbial Metabolism and Applications
- Growth Hormone and Insulin-like Growth Factors
- Pituitary Gland Disorders and Treatments
- PARP inhibition in cancer therapy
- Computational Drug Discovery Methods
- Cancer Cells and Metastasis
- Nutrition, Genetics, and Disease
- interferon and immune responses
- Pluripotent Stem Cells Research
- Telomeres, Telomerase, and Senescence
- Transgenic Plants and Applications
- Quinazolinone synthesis and applications
- Cellular Mechanics and Interactions
GlaxoSmithKline (United States)
2025
Cancer Institute (WIA)
2024
University College London
2015-2024
MRC Laboratory for Molecular Cell Biology
2015-2024
Moffitt Cancer Center
2019-2021
Scripps Institution of Oceanography
2018-2019
Scripps Research Institute
2015-2019
Scripps (United States)
2018-2019
Centre National de la Recherche Scientifique
2019
Spanish National Cancer Research Centre
2007-2015
The peripheral nervous system has remarkable regenerative capacities in that it can repair a fully cut nerve. This requires Schwann cells to migrate collectively guide regrowing axons across ‘bridge’ of new tissue, which forms reconnect severed Here we show blood vessels direct the migrating cords cells. multicellular process is initiated by hypoxia, selectively sensed macrophages within bridge, via VEGF-A secretion induce polarized vasculature relieves hypoxia. then use as “tracks” cross...
The adult endocrine pituitary is known to host several hormone-producing cells regulating major physiological processes during life. Some candidates progenitor/stem have been proposed. However, not much about cell renewal throughout life and its homeostatic regulation specific changes, such as puberty or pregnancy, in pathological conditions tumor development.We identified rodents humans a niche of non-endocrine characterized by the expression GFRa2, Ret co-receptor for Neurturin. These also...
Casein kinase 1δ promotes breast tumorigenesis by activation of β-catenin and can be targeted in some cancers.
Abstract SMCHD1 is a component of the structural maintenance chromosomes (SMC) protein family involved in epigenetic gene silencing X chromosome and other autosomal regions. encodes an ATPase domain binds chromatin at both N- C-term domains to facilitate long-range interactions. However, exact mechanism by which it elicits transcriptional remains unknown. We have identified selective dependency on cell lines exhibiting expression signature characterized high multiple cancer testis antigen...
The formation of myelinating Schwann cells (mSCs) involves the remarkable biogenic process, which rapidly generates myelin sheath. Once formed, mSC transitions to a stable homeostatic state, with loss this stability associated neuropathies. histone deacetylases deacetylase 1 (HDAC1) and HDAC2 are required for myelination transcriptional program. Here, we show distinct role HDAC3, in that, while dispensable mSCs, it is essential sheath once formed—with resulting progressive severe neuropathy...
Collective cell migration is fundamental for the development of organisms and in adult tissue regeneration pathological conditions such as cancer. Migration a coherent group requires maintenance cell-cell interactions, while contact inhibition locomotion (CIL), local repulsive force, can propel forward. Here we show that interaction molecule, N-cadherin, regulates both adhesion repulsion processes during Schwann (SC) collective migration, which required peripheral nerve regeneration....
Glioblastoma (GBM) is the most aggressive primary brain cancer with an average survival time after diagnosis of only 12-14 months, few (<5%) long-term survivors. A growing body work suggests that GBMs contain a small population glioma stem cells (GSCs) are thought to be major contributors treatment resistance and disease relapse. Identifying compounds modulate GSC proliferation would provide highly valuable molecular probes GSC-directed signaling. However, targeting GSCs pharmacologically...
Aberrant activation of Wnt/β-catenin signaling is strongly associated with many diseases including cancer invasion and metastasis. Small-molecule targeting the central node this pathway, β-catenin, a biologically rational approach to abolish hyperactivation β-catenin but has been demonstrated be difficult task. Herein, we report drug-like small molecule, ZW4864, that binds selectively disrupts protein–protein interaction (PPI) between B-cell lymphoma 9 (BCL9) while sparing...
Glioblastoma multiforme (GBM) is the most aggressive and common form of adult brain cancer. Current therapeutic strategies include surgical resection, followed by radiotherapy chemotherapy. Despite such multimodal therapy, prognosis remains poor, with a median patient survival 14 months. A proper understanding molecular drivers responsible for GBM progression are therefore necessary to instruct development novel targeted agents enable design effective treatment strategies. Activation c-Jun...
Abstract Cellular DNA is constantly under threat from internal and external insults, consequently multiple pathways have evolved to maintain chromosomal fidelity. Our previous studies revealed that chronic stress, mediated by continuous stimulation of the β 2 -adrenergic-βarrestin-1 signaling axis suppresses activity tumor suppressor p53 impairs genomic integrity. In this pathway, βarrestin-1 (βarr1) acts as a molecular scaffold promote binding degradation E3-ubiquitin ligase, MDM2. We...
Although gemcitabine is the cornerstone of care for pancreatic ductal adenocarcinoma (PDA), patients lack durable responses and relapse inevitable. While underlying mechanisms leading to resistance are likely be multifactorial, there a strong association between activating metabolism pathways clinical outcome. This study evaluated casein kinase 1 delta (CK1δ) as potential therapeutic target PDA bladder cancer, in which CK1δ frequently overexpressed. We assessed antitumor effects genetically...
Abstract The extrinsic apoptotic pathway activates programmed cell death through the binding of extracellular ligands, such as TNFα, to their cognate receptors. Although some ligands are often upregulated in tumor microenvironment, this is subverted cancer cells instead favor growth and survival rather than induction apoptosis. Reflecting strict control exert over pathway, functional genomics screens, DepMap, have identified several components essential targets, with selective dependency a...
<p>Supplementary figures 1 through 8.</p>
<p>Supplementary figures 1 through 8.</p>
<div>Abstract<p>Although gemcitabine is the cornerstone of care for pancreatic ductal adenocarcinoma (PDA), patients lack durable responses and relapse inevitable. While underlying mechanisms leading to resistance are likely be multifactorial, there a strong association between activating metabolism pathways clinical outcome. This study evaluated casein kinase 1 delta (CK1δ) as potential therapeutic target PDA bladder cancer, in which CK1δ frequently overexpressed. We assessed...