A5034049239- Ear Surgery and Otitis Media
- Voice and Speech Disorders
- Ear and Head Tumors
- Head and Neck Anomalies
- Facial Nerve Paralysis Treatment and Research
- Phonetics and Phonology Research
- Congenital Ear and Nasal Anomalies
- Nasal Surgery and Airway Studies
- Hearing Loss and Rehabilitation
- Metastasis and carcinoma case studies
- Tracheal and airway disorders
- Head and Neck Surgical Oncology
- Hearing, Cochlea, Tinnitus, Genetics
- Bone Tumor Diagnosis and Treatments
- Sinusitis and nasal conditions
- Congenital heart defects research
- Cancer Cells and Metastasis
- Meningioma and schwannoma management
- Autism Spectrum Disorder Research
- Immune Cell Function and Interaction
- Mitochondrial Function and Pathology
- Delphi Technique in Research
- ATP Synthase and ATPases Research
- Otolaryngology and Infectious Diseases
- Shoulder and Clavicle Injuries
Gunma University
2024-2025
Jikei University School of Medicine
2018-2024
The Jikei University Hospital
2024
Prefectural University of Hiroshima
2024
Howard Hughes Medical Institute
2022
National Institutes of Health
2022
Wellcome Trust
2022
Textron Systems (United Kingdom)
2022
Nagoya City University
2018
Tokyo Teishin Hospital
2010
Cholesteatoma is a progressive middle ear disease that can only be treated surgically but with high recurrence rate. Depending on the extent of disease, surgical approach, such as microsurgery retroarticular incision or transcanal endoscopic surgery, performed. However, current examination cannot sufficiently predict progression before and changes in approach may made during surgery. Large amounts data are typically required to train deep neural network models; however, prevalence...
This study aimed to quantitatively evaluate whether non-echoplanar diffusion-weighted MRI (non-EP DWI) lesion size and detectability can predict mastoid extension complications such as labyrinthine fistula dural exposure in middle ear cholesteatoma. retrospective included 120 lesions with surgically confirmed Non-EP DWI was performed within 6 months preoperatively evaluated for measurements, including maximum axial diameter, area, volume. Surgical findings were used assess extension,...
Osteoma of the middle ear is a rare condition in which tumors composed mature bone grow. In present study, we experienced case an osteoma causing obstruction supratubal recess Eustachian tube, resulting depression pars flaccida tympanic membrane and fixation ossicles. The patient, 37-year-old woman, had been aware hearing loss for two years. Tympanic findings showed membrane, audiometry mixed impairment. A temporal computed tomography (CT) spherical recess, with ossicles adhering to canopy...
Abstract The MYO7A gene is known to be responsible for both syndromic hearing loss (Usher syndrome type1B:USH1B) and non-syndromic including autosomal dominant recessive inheritance (DFNA11, DFNB2). However, the prevalence detailed clinical features of -associated across a large population remain unclear. In this study, we conducted next-generation sequencing analysis cohort 10,042 Japanese patients. As result, 137 patients were identified with so that among was 1.36%. We 70 disease-causing...
Interleukin‑10 (IL‑10) is a highly pleiotropic cytokine that regulates immunological homeostasis through anti‑inflammatory and/or immunostimulatory functions. Moreover, IL‑10 well known to exert diverse roles in tumor immunology and immunotherapy. The present study investigated the presence of circulating antigen‑specific IL‑10‑producing T cells patients with head neck squamous cell carcinoma (HNSCC), determined factors may influence immunodynamics cells.<em> In vitro</em>, peripheral blood...
Tympanoplasty using the interlay technique has rarely been reported in transcanal endoscopic ear surgery, unlike underlay technique. This is because many surgeons find it challenging to detach epithelial layer of tympanic membrane only one hand. However, can be easily detached from inferior part membrane. Another key point actively improve anteroinferior visibility even if overhang slight most perforations and postoperative reperforations are found quadrant We report application...
Objective To analyze the time trends of recidivism acquired cholesteatoma using Kaplan-Meier method. Study Design We conducted a retrospective, observational study 256 patients having their first surgery. The cumulative recidivism-free rate was calculated survival analysis related to follow-up period, pathophysiology, extent disease, and pathologies. Results Pars flacida with tympanic cavity progression had high likelihood recurrence disease. tensa led more disease than residual In both pars...
Partial epithelial-mesenchymal transition (p-EMT) is a process by which epithelial cells partially lose their intercellular adhesion and change to obtain migration ability. The transcription factor p63 regulates the expression of cadherin family induces cell proliferation. In this study, we hypothesized that p-EMT under may be key in growth middle ear cholesteatoma.Specimens were surgically excised from patients with congenital cholesteatoma (CC) (n = 48), acquired (AC) 120), normal skin...
Recurrent middle-ear infection can lead to ossicular fixation, adversely affecting post-tympanoplasty hearing outcomes. Preoperative prediction of fixation remains challenging. We aimed investigate potential predictors in patients with chronic otitis media.Retrospective.Tertiary academic medical center.Patients noncholesteatomatous media and tympanic membrane perforation, without discontinuities.Diagnostic.The each ossicle was assessed during tympanoplasty. The impact preoperative otoscopic...
To assess the clinical characteristics of extent patterns in pars tensa cholesteatoma.This was a retrospective chart review. Forty-four patients with cholesteatoma who underwent primary surgery at tertiary academic medical center were included. The main outcomes measured sex, age, background, and stage classification (including involvement sinus tympani) according to two staging classifications: criteria advocated by Japanese Otological Society (JOS) those European Academy Otology...
The middle ear transmits sound to the inner via vibrations in eardrum and ossicles, damage results conductive hearing loss. Although loss can be corrected by surgery, currently available clinical investigations cannot always diagnose ossicular chain pathology underlying loss, even intraoperative findings equivocal. Acoustic analysis using finite element models (FEMs) simulate pressure change at an arbitrary site for each frequency. FEMs are used acoustic engineering frequency-dependent...
The Japan Otology Society (JOS) proposed the classification and staging system for middle ear cholesteatoma. However, there was little analysis of pathology cholesteatoma using this system.To analyze pars flaccida by JOS.A total 183 cases fresh treated between January 2009 December 2015 were included. We used recommended JOS (2015). association following variables in each stage examined: age, gender, preoperative hearing level, staging, statuses mastoid cell growth stapes, tympanic sinus...
Background: The mastoid air cells are considered to develop better in children with congenital cholesteatoma but only a few quantitative studies have examined.Aims/objectives: present study was undertaken order clarify the relationships between development of and clinical factors.Materials methods: Mastoid cell evaluated 53 cholesteatoma. sizes were measured on computed tomography scans temporal bone, factors, including age, extent invasion, whether it located close eustachian tube...
Biallelic missense mutations in the nuclear-encoded, cytosolic isoleucyl-tRNA synthetase (IARS) gene are associated with a rare and complex multisystemic phenotype, including growth retardation, intellectual disability, muscular hypotonia, diabetes mellitus, deafness. These impact isoform of IARS, which plays crucial role protein synthesis. The pathogenesis involves mitochondrial dysfunction, despite IARS being primarily enzyme, potentially linking it to observed clinical manifestations....
Transcanal endoscopic ear surgery enables surgeons to operate with few blind areas, and using an angled endoscope expands its usefulness. We have previously reported the usefulness of a 70° in transcanal surgery, but no quantitative study has been performed. quantitatively clarified difference between microscope various endoscopes bone removal region, especially endoscope, approach.A temporal model for training was used compare use microscope, 0° 30° 45°endoscope, endoscope. The drilled mass...
The progression of a cervical abscess toward the mediastinum is rare but remains one most serious diseases, even in era antibiotics. A mediastinal can originate from an odontogenic infection and presents challenge for otolaryngologists craniofacial surgeons, particularly when it spreads caudally to tracheal bifurcation. For successful treatment such abscess, patients are generally referred thoracic surgeon drainage. We present distinctive case infection-induced wide that could be drained...
Background This study aimed to evaluate the quality of life (QOL) older adults using cochlear implants (CIs) by focusing on how individual characteristics and speech perception are related generic QOL ratings utilizing Health Utilities Index Mark III (HUI3) for assessment. Methodology A cross-sectional was conducted with 19 participants aged ≥60 years, who were within one five years post-implant activation. Data obtained through self-administered questionnaires, including HUI3 assessment...