A5101850640- Dementia and Cognitive Impairment Research
- Stroke Rehabilitation and Recovery
- Balance, Gait, and Falls Prevention
- Physical Activity and Health
- Acute Ischemic Stroke Management
- Nutrition and Health in Aging
- Sleep and related disorders
- Delphi Technique in Research
- Health Systems, Economic Evaluations, Quality of Life
- Blood Pressure and Hypertension Studies
- Spaceflight effects on biology
- Health, Environment, Cognitive Aging
- Frailty in Older Adults
- COVID-19 and Mental Health
- Vitamin D Research Studies
- Cardiovascular and exercise physiology
- Cerebral Palsy and Movement Disorders
- Sleep and Wakefulness Research
- Intensive Care Unit Cognitive Disorders
- Diet and metabolism studies
- Cerebrovascular and Carotid Artery Diseases
- Health and Well-being Studies
- Behavioral Health and Interventions
- Cardiovascular and Diving-Related Complications
- Neurological Disease Mechanisms and Treatments
University of British Columbia
2014-2025
Vancouver Coastal Health
2019-2025
Vancouver Coastal Health Research Institute
2019-2025
Columbia University
2024
American Physical Therapy Association
2024
British Columbia Centre of Excellence for Women's Health
2018
Cambridge University Press
2017
International Society of Nephrology
2017
Importance Exercise, cognitive training, and vitamin D may enhance cognition in older adults with mild impairment (MCI). Objective To determine whether aerobic-resistance exercises would improve relative to an active control if a multidomain intervention including exercises, computerized supplementation show greater improvements than exercise alone. Design, Setting, Participants This randomized clinical trial (the SYNERGIC Study) was multisite, double-masked, fractional factorial that...
Background and Purpose: We investigated the effect of higher therapeutic exercise doses on walking during inpatient rehabilitation, typically commencing 1 to 4 weeks poststroke. Methods: This phase II, blinded-assessor, randomized controlled trial recruited from 6 Canadian rehabilitation units, between 2014 2018. Subjects (n=75; 25/group) were into: control (usual care) physical therapy: typically, hour, 5 days/week; Determining Optimal Post-Stroke Exercise (DOSE1): days/week, more than...
OBJECTIVE Infection with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), which causes disease 2019 (COVID‐19), manifests a wide spectrum of presentations. Most reports COVID‐19 highlight fever and upper symptoms as the dominant initial presentations, consistent World Health Organization guidelines regarding suspected SARS‐CoV‐2 infection. However, atypical presentations this have been evolving since outbreak pandemic in December 2019. We report case an older male patient who...
Importance A stroke doubles one’s risk for dementia. How to promote cognitive function among persons with chronic is unclear. Objective To evaluate the effect of exercise (EX) or and social enrichment activities (ENRICH) on in adults stroke. Design, Setting, Participants This was a 3-group parallel, single-blinded, single-site, proof-of-concept randomized clinical trial at research center Vancouver, British Columbia, Canada. included community-dwelling stroke, aged 55 years older, able walk...
Acknowledging the detrimental effects of prolonged sitting, this study examined an acute exercise break during sitting on executive function, cortical hemodynamics, and microvascular status. In randomized crossover study, 71 college students completed three conditions: (i) uninterrupted (SIT); (ii) SIT with a 15 min moderate-intensity cycling (MIC); (iii) vigorous-intensity (VIC). Behavioral outcomes, retinal vessel diameters (central artery equivalents [CRAE], vein [CRVE], arteriovenous...
<b><i>Introduction:</i></b> Executive function is responsive to exercise and predictive of subsequent falls. Minimal clinically important differences (MCIDs) are critical for understanding whether observed changes meaningful. However, MCIDs many cognitive measures not established. We aimed determine the Digit Symbol Substitution Test ([DSST] processing speed measure), Stroop (inhibition Trail Making B-A (TMT; set-shifting using anchor- distribution-based approaches in...
Abstract Weightlessness during spaceflight can harm various bodily systems, including bone density, muscle mass, strength and cognitive functions. Exercise appears to somewhat counteract these effects. A terrestrial model for this is head‐down bedrest (HDBR), simulating gravity loss. This mirrors challenges faced by older adults in extended space environments. The first Canadian study, backed the Space Agency, Institutes of Health Research, Frailty Network, aims explore issues. study seeks...
Impaired cognition and mobility are common in older adults they often coexist due to shared pathophysiology.1 Worldwide, one new case of dementia is detected every 3 s.2 Exercise improves cognitive function reduces the risk disability falls.3–5 Leaders physical activity exercise research aiming delineate what (e.g., type, duration, frequency intensity) should be recommended when midlife versus late life) it best done for promoting outcomes healthy individuals those at impairment. Two other...
Activities which simultaneously challenge both physical and cognitive function are promising strategies for promoting function.To examine the effects of resistance exercise with instability traditional compared a health education control on in older adults complaints.Sixty-seven participants were randomized to either 12 weeks thrice-weekly (RE = 23), RE (REI 22), or weekly (CON 22). At each training session, REI performed seven exercises three sets 10-15 repetitions. using devices. The...
Importance Cognitive impairment is prevalent in survivors of stroke, affecting approximately 30% individuals. Physical exercise and cognitive social enrichment activities can enhance function patients with chronic but their cost-effectiveness compared a balance tone program uncertain. Objective To conduct cost-utility analysis multicomponent or program. Design, Setting, Participants This economic evaluation used Canadian health care systems perspective the Vitality study, randomized clinical...
To provide a comprehensive CERT (Consensus on Exercise Reporting Template)-based description of the resistance exercise program implemented in AGUEDA (Active Gains brain Using During Aging) study, randomized controlled trial investigating effects 24-week supervised executive function and related structure cognitively normal older adults. 90 adults aged 65 to 80 were (1:1) a: 1) group; or 2) wait-list control group. Participants group (n = 46) performed 180 min/week (3 sessions per week, 60...
Aim: Resistance exercise (RE) is a widely accepted strategy to counteract the effects of aging and chronic diseases on health-related outcomes. Studies have been suggested that RE improves brain cognitive health. with unstable devices (REI) neuromotor complexity potential improve strength, power, balance in onder adults, however, their neurocognitive function individuals at risk decline are poorly understood. Thus, we describe REI study protocol, randomized clinical trial design assess...
Abstract Background Circadian rhythms (i.e., the ∼24‐hour biological clock) are critical to maintenance of sleep‐wake cycle, and disturbances common in people at risk for cognitive decline dementia. Several studies have identified circadian factors associated with using actigraphy (a field measure indexing cycle). However, there currently untapped opportunities use power artificial intelligence, specifically machine learning (ML), improve our ability identify signs from data. As a first step...
Abstract Background Exercise (EX) or cognitive and social enrichment (ENRICH) are two promising strategies for promoting function post-stroke. Sleep may moderate the effects of these interventions on cogntion, whereby intervention be more robust among individuals suffering from poor sleep. We examined whether sleep moderates EX ENRICH in adults with chronic stroke. Methods Secondary analysis a three-arm parallel, single-blinded, randomized clinical trial community-dwelling aged 55+ years...
Abstract An unintended side-effect of the COVID-19 pandemic has been changes in lifestyle factors which impact middle-aged and older adult cognition – including 24-hour behaviours (i.e., physical activity, sedentary behaviour, sleep). In a longitudinal analysis Canadian Longitudinal Study on Aging (CLSA) tracking cohort, we explored age- sex-differences effects behaviours, whether pandemic-related are associated. We included cognitively healthy participants at baseline (2012-2105), follow-up...
Abstract Bed rest can occur because of chronic conditions, injury, or hospitalization and initiate a downward spiral deleterious changes in several body systems. Exercise is countermeasure to many these changes. However, its impact on middle-aged older adults’ brain functional connectivity (FC) during bed remains unexplored. We examined the effects exercise resting-state FC adults exposed 14 days experimental 6° head-down (HDBR). conducted non-blinded, parallel-group, randomized controlled...
Abstract Exercise (EX) and cognitive/social enrichment (ENRICH) are promising strategies for promoting cognitive function post-stroke. The effects of these interventions on may vary by biological sex, i.e. males (M) vs females (F). We conducted a secondary analysis three-arm, six-month, assessor-blinded, randomized clinical trial among 120 community-dwelling adults aged 55+ years with chronic stroke (i.e., ≥12 months since stroke), to examine if sex moderates the EX or ENRICH function....