A5001034866- Pediatric health and respiratory diseases
- Neonatal and Maternal Infections
- Immune Response and Inflammation
- Viral gastroenteritis research and epidemiology
- Parvovirus B19 Infection Studies
- Streptococcal Infections and Treatments
- Respiratory viral infections research
- Viral Infections and Vectors
- COVID-19 Clinical Research Studies
- Cytomegalovirus and herpesvirus research
- Sepsis Diagnosis and Treatment
- Dermatological and COVID-19 studies
- Human Health and Disease
- Inflammasome and immune disorders
- Digestive system and related health
- Pneumonia and Respiratory Infections
- HIV, TB, and STIs Epidemiology
- Clostridium difficile and Clostridium perfringens research
- Reproductive System and Pregnancy
- Kawasaki Disease and Coronary Complications
- Infant Nutrition and Health
- Hepatitis Viruses Studies and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Bacterial Infections and Vaccines
- Herpesvirus Infections and Treatments
Kazan State Medical University
2015-2024
Kazan State Medical Academy
1997-2024
N. I. Lobachevsky State University of Nizhny Novgorod
2021
Lomonosov Moscow State University
2017
Institute of Chemical Biology and Fundamental Medicine
2016
University of Nevada, Reno
2016
Kazan Federal University
2016
Kazan Research Institute of Epidemiology and Microbiology
2003
Infectious Clinical Hospital No. 1
1982-1997
Regional Center for Prevention and Control of AIDS and Infectious Diseases
1997
Introduction:Klebsiella pneumoniae is one of the most important infectious agents in neonates. There are "classic" and hypervirulent strains K. pneumoniae. The non-virulent strain pneumoniae, producing extended-spectrum beta-lactamases (ESBLs), associated with nosocomial infections. Hypervirulent invasive infections previously healthy adult people, them exhibit antimicrobial susceptibility. role virulent (including hv-KP) neonatal unknown. aim study was assessment impact virulence factors...
Neonatal sepsis is a significant health issue associated with high mortality. Immune responses neonatal sepsis, such as proinflammatory cytokine production, are believed to play central role in the pathogenesis of this disease. In present study, serum levels cytokines TNF- α , IL1- β and IL-6 anti-inflammatory IL-4 IL-10 were evaluated for 25 subjects sepsis. We observed that late onset (LOS), well those early (EOS), had substantial increase . contrast EOS, LOS demonstrated IL-10....
Hantavirus infection is an acute zoonosis that clinically manifests in two primary forms, hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary (HPS). HFRS endemic Europe Russia, where the mild form of disease prevalent Tatarstan region. HPS Argentina, as well other countries North South American. are usually acquired via upper respiratory tract by inhalation virus-contaminated aerosol. Although pathogenesis remains largely unknown, postmortem tissue studies have identified...
Klebsiella pneumoniae is one of the most important infectious agents among neonates. This pathogen has a potential to develop an increased antimicrobial resistance and virulence. The classic nonvirulent strain K. pneumoniae, producing extended-spectrum beta-lactamases (ESBL), associated with nosocomial infection mainly in preterm Hypervirulent strains are invasive previously healthy ambulatory patients, them exhibit susceptibility. During last few years, several cases diseases caused by...
Aims: Nephropathia epidemica (NE) is a form of hemorrhagic fever with renal syndrome associated the Puumala virus species Hantavirus. The pathogenesis NE not well understood; therefore, investigating inflammatory cytokine response to infection may provide useful knowledge in deciphering pathophysiology NE. Materials & methods: Using Luminex and ELISA, we analyzed serum 137 cases 44 controls investigate if cytokines associate different clinical presentations. Results: Serum levels TNF-α IL-1β...
Background Russia has a substantial HIV epidemic which is poised to escalate in the coming years. The increases prevalence of will result increased healthcare needs by medical system with limited experience HIV. A provider's attitude towards patient plays significant role determining patient's health‐related behaviours and outcomes. Previous studies have identified negative attitudes students people living Studying such particular interest, as represent future workforce also schooling years...
The genetic background of an individual plays important role in the progression HIV infection to AIDS. Identifying previously unknown or uncharacterized single nucleotide polymorphisms (SNPs) that associate with disease may reveal therapeutic targets and provide a greater understanding pathogenesis. In present study, we employed ultra-high multiplex PCR on Ion Torrent next-generation sequencing platform sequence 23 innate immune genes from 94 individuals HIV/AIDS. This data was used identify...
Plasmacytoid dendritic cells (pDCs) in the periphery of subjects with human immunodeficiency virus (HIV)/acquired syndrome (AIDS) decrease over time, and fate these has been subject ongoing investigation. Previous studies using animal models as well humans suggest that may redistribute to gut. Other propose pDCs are depleted gut is repopulated naive from bone marrow. In present study, we utilized immunohistochemistry survey duodenum biopsies HIV/AIDS controls. We observed had increased...
Kidney insufficiency is a hallmark of nephropathia epidemica (NE). Little known about the mechanisms NE kidney pathology, with current knowledge mainly based on findings in postmortem tissue. We have analyzed damage biomarkers urine collected from early- and late-phase using Bio-Plex toxicity panels 1 2. To determine disease specificity, were also samples patients diagnosed gout, type 2 diabetes, systemic lupus erythematosus, chronic insufficiency. Analysis 12 suggests to proximal tubule at...
Erythema infectiosum is the main clinical variant of infection associated with parvovirus B19 in children. Clinical symptoms include mild fever, erythema on cheeks («a slapped face» symptom), and a maculopapular rash body that becomes lacy over time. But this characteristic not always recorded. Parvovirus various skin lesions require differential diagnosis tick-borne borreliosis, sudden exanthema, hemorrhagic vasculitis, systemic lupus erythematosus, etc. The considered using example...
Every year, a seasonal increase in the incidence of respiratory infections is registered Russian Federation, primarily among children. It significantly increases burden on outpatient pediatric service. especially important to optimize daily practice pediatricians by developing algorithms and updating treatment protocols, as well creating conducting training programs. Fever leading symptom acute viral one most common reasons for seeking help services. Leading experts field therapy pediatrics...
Increasing market competition requires the examination of marketing methods and tools in territorial management. Place has been developing with some delay compared to value marketing, as it emerged later, shaping its theoretical practical basis accordingly. We analyse for assessing competitiveness context place marketing. The research methodology includes monitoring, comparison, analysis, synthesis, benchmarking. study evolution ideas concerning revealed three important concepts: production,...
Nephropathia epidemica (NE) is a mild form of hemorrhagic fever with renal syndrome. Several reports have demonstrated severe alteration in lipoprotein metabolism. However, little known about changes circulating lipids NE. The objectives this study were to evaluate serum total cholesterol, high density cholesterol (HDCL), and triglycerides. In addition evaluation cytokine activation associations, lipid profile determined for gender, thrombocyte counts, VEGF. Elevated levels triglycerides...
Педиатрия 82 4. Титович, Е. В. HLA-гаплотипы, аутоантитела к (β-клеткам: роль в прогнозировании сахарного диабета 1 типа (результаты 11
The article presents an overview of modem ideas about the etiological structure, principles diagnosis and therapy acute intestinal infections in children. authors comment on features treatment these patients, existing today domestic foreign practice. As part evidence-based medicine shows efficacy various drugs for children with infectious diarrhea. used results their research to substantiate position discussions several issues improving diagnostic therapeutic approaches working patients infections.
Klebsiella is one of the most common causes neonatal sepsis. Cases caused by extended-spectrum β-lactamase-producing strains are relevance. The infections these bacterial resistant to majority cephalosporins commonly used in practice and lead significant mortality. development their clinical forms, including severe ones, determined a number virulence factors that include capsular antigen, lipopolysaccharide, pili, siderophores. Despite fact probability sepsis highest premature infants,...
The purpose was to study the clinical and epidemiological features of respiratory syncytial virus infection in hospitalized children first year life with lower tract diseases different regions Russian Federation (Russia) during 2015–2016 epidemic season. Materials methods : original data a multicentre observational conducted on basis children’s hospitals St. Petersburg, Arkhangelsk, Kazan, Saratov are presented. Etiology acute viral infections were confirmed by examination smears from...
Purpose. To evaluate clinical and epidemiological features of neonatal sepsis assess the impact organ dysfunction on its outcome. Characteristics children research methods. The authors carried out a retrospective analysis 66 patients with hospitalized to intensive care unit Kazan City Children’s Hospital No. 1 from 2013 2017. diagnosis was based development systemic inflammatory response syndrome, an increase in C-reactive protein concentration blood more than mg/dl, presence one or foci...
The article presents modern data on etiology, epidemiology, clinical manifestations of infection caused by the herpes simplex viruses type 6. problems ofthe use oflaboratory methods research and treatment ofinfections.
Currently, the researchers from various countries have demonstrated that COVID-19 in children is diagnosed less frequently, and course severity of pathological process pronounced than adults. Children with often asymptomatic mild forms. However, risk developing severe typical for groups. Newborns young children, congenital malformations concomitant diseases, primarily accompanied by immunodeficiency states etiologies (oncological autoimmune diabetes mellitus) are factors development forms...
The aim of the work is to evaluate prevalence herpes virus infection nasopharynx mucosa in children with hypertrophy adenoid and palatine tonsils improve complex treatment methods. An open continuous prospective analytical study was carried out, which included examination 186 patients chronic adenoiditis. were divided into three groups. first group 146 a diagnosis adenoids grade 3 – 90 people; 3, 2-3 56 people. Endoscopic adeno- or adenotonsillotomy performed group. Patients second had 1–2...
Multisystem inflammatory syndrome in children associated with COVID-19 is a new disease, information first appeared April 2020. There were reported cases of hospitalized unusual symptoms, manifested primarily by fever and multisystem inflammation from the pediatricians UK other countries during coronavirus infection pandemic (COVID-19). Some these critical condition symptoms shock multiple organ failure, some had manifestations similar to Kawasaki disease. Despite fact that relatively easy,...
Aim. To assess the changes in intestinal microbiota patients with HIV. Methods. The cultures of stool samples 317 different stages HIV [13 (4.1%) - acute infection stage (2A, 2B, 2C), 217 (68.5%) III, 87 (27.4%) IVA-B according to classification by Pokrovsky V.I., 2001] were examined plating on growth medium and further microbiologic examination. Results. Changes found 94% patients. decrease obligatory microorganisms quantity, especially bifidobacteria (lower than reference ranges 70.3%...