A5003066563- Colorectal Cancer Surgical Treatments
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Screening and Detection
- Colorectal and Anal Carcinomas
- Lung Cancer Treatments and Mutations
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Cancer Treatment and Pharmacology
- Cancer Genomics and Diagnostics
- Multiple and Secondary Primary Cancers
- Inflammatory Biomarkers in Disease Prognosis
- COVID-19 and healthcare impacts
- Neutropenia and Cancer Infections
- Antifungal resistance and susceptibility
- Gastric Cancer Management and Outcomes
- Hormonal Regulation and Hypertension
- Pelvic floor disorders treatments
- Fungal Infections and Studies
- Diet and metabolism studies
- Infectious Diseases and Mycology
- Urinary Bladder and Prostate Research
- Frailty in Older Adults
- Radiomics and Machine Learning in Medical Imaging
- Hernia repair and management
Hospital Universitario La Paz
2000-2025
Universidad El Bosque
2025
Fundación Santa Fe de Bogotá
2025
Hospital Juan Ramón Jiménez
2025
Arcadia
2024
Hospital La Paz Institute for Health Research
2023
Medico
2023
Universidad de Valladolid
2019
Universidad Complutense de Madrid
1986-1996
Xunta de Galicia
1993
Objective: To test whether oxidative stress could promote a systemic acute-phase response in elderly patients with type II diabetes. Design and Methods: In group of 30 older diabetic poor glycemic control, serum levels lipid peroxides, measured as thiobarbituric acid-reacting substances (TBARS); C-reactive protein (CRP); interleukin (IL)-6 the soluble form its receptor (sIL-6R), were evaluated at baseline after 2 3 months therapeutic intervention. Thirty asymptomatic, untreated individuals...
O estudo teve objetivo geral analisar os reflexos do inchaço Judiciário na aplicação processual direito de família, considerando a precarização sistema judiciário e as perspectivas da doutrina brasileira. E foram objetivos específicos: descrever bases legais família dentro dos parâmetros legislativos; identificar vertentes que versam o família; discutir sobre principais consequências brasileiro tramitação processos no âmbito família. Trata-se uma pesquisa bibliográfica exploratória, método...
Abstract Background Stage II and III colorectal cancer (CRC) poses a significant challenge due to rising global incidence mortality rates. Despite advancements in screening treatment, there’s pressing need for reliable prognostic biomarkers. Tumor budding emerges as promising marker associated with poor prognosis higher recurrence. However, its incorporation into clinical guidelines differs when considering adjuvant treatment. This study assesses tumor budding’s value recurrence stage CRC,...
Las fracturas de radio distal son la patología traumática más frecuente del miembro superior, su presentación es bimodal, predominando en mujeres mayores 50 años que presenten algún grado osteopenia.El síndrome doloroso regional complejo (SDRC) una condición dolorosa anormalmente intensa e inexplicablemente prolongada y crónica, con manifestaciones autonómicas inflamatorias, atrofia compromiso funcional, compromete estructuras músculo-esqueléticas, nerviosas vasculares, afectando...
The occurrence of transverse linear milia cysts over the dorsum nose in an 11-year-old girl is described. Two younger sisters proband had a conspicuous nasal groove at same site without milia. anatomical basis and pathogenesis so-called 'transverse crease' are reviewed.
181 Background: Patients with microsatellite-instability–high (MSI-H) or deficient mismatch repair (dMMR) colorectal cancer (CRC) represent a unique subgroup of patients evolving treatment opportunities. Methods: We included all the pathologically confirmed diagnosis CRC at Hospital Universitario La Paz from October 2016 to September 2020. Results: A total 1,152 were diagnosed CRC. IHC for MMR was available in 1,014 patients. Of those, 100 (9,8%) MLH1 and PSM2 (n = 78), MSH2 MSH6 12), PMS2...
K-ras activating point mutations appear to have a role in human lung cancer, however, the prognostic significance of these abnormalities remains unclear. The aim our work was clarify as indicators patients affected by non-small cell cancer (NSCLC). We studied 94 resected primary NSCLCs for PCR-RFLP technique, followed sequencing. were present 34% tumors, higher incidence being detected adenocarcinomas. Comparing impact mutation types, we found that transversions associated with shorter...
Background: The prognosis of patients with stage II and III colon cancer is heterogeneous. Clinical pathological characteristics, such as tumor budding, may help to further refine the recurrence risk. Methods: We included all localized at Hospital Universitario La Paz from October 2016 2021. built a prognostic score for in training cohort based on multivariate cox regression analysis categorized into two risk groups. Results: A total 440 were cohort. After median follow-up 45 months, 81...
Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors are usually combined with fulvestrant or aromatase for the treatment of patients metastatic breast cancer (mBC). Drug-drug interactions may affect absorption by different mechanims, instance, modification digestive pH. Proton pump (PPIs) known to reduce oral bioavailability some anticancer drugs. Palbociclib is a weak base pH-dependent solubility, therefore variations in gastric pH could its absorption. The objective this study was evaluate...
A 76-year-old man with stage IV urothelial carcinoma who was receiving atezolizumab presented dyspnea, elevated cardiac biomarkers, new negative T waves, and left ventricular apical akinesia. Coronary angiography results were normal. Immune checkpoint inhibitor-related myocarditis suspected, high-dose corticosteroid treatment started. Cardiac magnetic resonance showed edema, suggesting stress cardiomyopathy. (Level of Difficulty: Beginner.).
The rising incidence of colorectal cancer (CRC) among young patients is alarming. We aim to characterize the clinico-pathological features and outcomes with early-onset CRC (EOCRC), as well impacts COVID-19 pandemic.We included all pathologically confirmed diagnoses at Hospital Universitario La Paz from October 2016 December 2021. EOCRC cut-off age was 50 years old.A total 1475 diagnosed were included, eighty (5.4%) whom had EOCRC. Significant differences found between later-onset regarding...
247 Background: Tumor budding has recently been recognized as one important prognostic factor for recurrence in patients with localized colon cancer. Nevertheless, not all guidelines consider tumor the decision-making process selecting adjuvant chemotherapy. We aim to assess value of a cohort stage II and III Methods: included pathologically confirmed diagnosis cancer at Hospital Universitario La Paz assessment available, from October 2016 August 2021. was reported following recommendations...
Background: MUTYH has been implicated in hereditary colonic polyposis and colorectal carcinoma. However, there are conflicting data refgarding its relationship to breast cancer. Therefore, we aimed assess if mutations contribute cancer susceptibility. Methods: We retrospectively reviewed 3598 patients evaluated from June 2018 2023 at the Hereditary Cancer Unit of La Paz University Hospital, focusing on those with detected variants. Results: Variants were 56 (1.6%, 95%CI: 1.2–2.0). Of 766...