A5101581923- Bone Metabolism and Diseases
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Bone health and treatments
- Asthma and respiratory diseases
- Spine and Intervertebral Disc Pathology
- IL-33, ST2, and ILC Pathways
- Cancer-related molecular mechanisms research
- Bone health and osteoporosis research
- Spinal Cord Injury Research
- Spinal Fractures and Fixation Techniques
- Nerve injury and regeneration
- Planarian Biology and Electrostimulation
- Bone and Dental Protein Studies
- Colorectal and Anal Carcinomas
- Immune cells in cancer
- Blood transfusion and management
- Eosinophilic Esophagitis
- Cervical and Thoracic Myelopathy
- Venous Thromboembolism Diagnosis and Management
- Extracellular vesicles in disease
- Colorectal Cancer Surgical Treatments
- Neonatal Respiratory Health Research
- Alkaline Phosphatase Research Studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
Qilu Hospital of Shandong University
2016-2025
Tongji Hospital
2018-2025
National Health and Family Planning Commission
2020-2025
Huazhong University of Science and Technology
2018-2025
China Medical University
2025
Tea Research Institute
2024
Hunan Academy of Agricultural Sciences
2024
Chinese Academy of Agricultural Sciences
2024
Ministry of Agriculture and Rural Affairs
2024
University of Benin
2022
Abstract Background As important players in cell-to-cell communication, exosomes (exo) are believed to play a similar role promoting fracture healing. This study investigated whether derived from bone marrow mesenchymal stem cells (BMMSC-Exos) could improve healing of nonunion. Methods BMMSC-Exos were isolated and transplanted into the site rat model femoral nonunion (Exo group) every week. Moreover, equal volumes phosphate-buffered saline (PBS) exosome-depleted conditioned medium (CM-Exo)...
Severe spinal cord injury (SCI) is caused by external mechanical injury, resulting in unrecoverable neurological injury. Recent studies have shown that exosomes derived from bone marrow mesenchymal stem cells (BMSCs-Exos) might be valuable paracrine molecules the treatment of SCI. In this study, we designed SCI models vivo and vitro then investigated possible mechanism successful repair BMSCs-Exos. vivo, established one Sham group two model groups. The Basso, Beattie, Bresnahan (BBB) scores...
Airway eosinophilic inflammation is a key feature of type 2 high asthma. The role epithelial microRNA (miR) in airway remains unclear. We examined the expression miR-221-3p bronchial brushings, induced sputum, and plasma from 77 symptomatic, recently diagnosed, steroid-naive subjects with asthma 36 healthy controls by quantitative PCR analyzed correlation between eosinophilia. found that epithelial, was significantly decreased Epithelial correlated eosinophil sputum biopsies, fraction...
Abstract This study aimed to probe into the effect of TRIM33 on oxidative stress‐induced apoptosis osteoblasts in osteoporosis and underlying mechanism. The was induced by H 2 O treatment tested flow cytometry. A mouse model conducted ovariectomy (OVX). function assessed vitro vivo experiments. mechanism determined immunoprecipitation, immunofluorescent staining co‐transfection Here, we found that expression lessened patients with positively correlated bone mineral density these patients....
During the past decades, lumbar fusion has increasingly become a standard treatment for degenerative spinal disorders. However, it also been associated with an increased incidence of adjacent-segment degeneration (ASD). Previous studies have reported less ASD in anterior surgeries; thus, authors hypothesized that integrity posterior complex plays important role ASD. This study was designed to investigate effect on adjacent instability after instrumentation and development ASD.To evaluate...
Osteopontin (OPN) plays important roles in the modulation of apoptosis, angiogenesis, immune response, and tumor invasion. Elevated osteopontin expression has been reported lung cancer tissues compared to counterpart normal tissues. This study examined whether genetic variations gene are associated with survival patients occurrence rate bone metastasis.Three hundred sixty stages I IV between 2003 2007 were recruited this same number healthy persons used as control. Three promoter...
Abstract Background Severe asthma is associated with substantial mortality and has unmet therapeutic need. A subset of severe characterized by neutrophilic airway inflammation. Classically activated (or M1) macrophages which express IL-12 IL-23 are neutrophilia in asthma. Exogenous IL-25 was reported to suppress intestinal inflammation animal models inflammatory bowel diseases via suppressing production. We hypothesize that ameliorates inhibiting macrophage M1 polarization the expression...
ABSTRACT Purpose: Low back pain is a global health problem in which more than 40% caused by lumbar intervertebral disc degeneration (LDD). ADAMTS‐5 (A disintegrin and metalloproteinase with thrombospondin motifs‐5) was shown to be involved LDD functional analyses. To identify whether there an association between LDD, what the contribution of genetic polymorphisms MD (Mean diffusivity) changes IVD (Intervertebral disc). We firstly genotyped selected SNPs (Single nucleotide polymorphisms)...
Serine peptidase inhibitor, clade B, member 10 (SERPINB10) expression is increased in IL-13-stimulated human bronchial epithelial cells and a murine model of allergic airway inflammation. However, the role SERPINB10 asthma remains unknown. We examined association between eosinophilia subjects with Serpinb10 inflammation an animal model. Epithelial mRNA protein were markedly ( n = 60) compared healthy controls 25). levels significantly correlated hyperresponsiveness (AHR) three parameters...
microRNA (miR)-218-5p is involved in cigarette smoke-induced airway inflammation. In our earlier asthma epithelial miRNA profiling data, miR-218-5p was the top 2 down-regulated miRNA. We hypothesize that plays a role inflammation.To unveil of and its target gene inflammation.We measured expression bronchial brushings patients (n = 50) healthy controls 15), analysed correlations between eosinophilia. examined whether CTNND2 miR-218-5p, 12 catenin family members brushings, cultured human (HBE)...
Oxidative stress can induce apoptosis and decrease activities of osteoblasts. Hyperoside (HYP) is a potent antioxidant derived from Chinese herb. This study aims to evaluate the protective effects provided by HYP osteoblastic MC3T3-E1 cells. cells were pre-treated with for 24 h before being treated 0.3 mM hydrogen peroxide (H2O2) h. Cell viability, flow cytometric analysis mRNA expression alkaline phosphatase (ALP), collagen I (COL-I) osteocalcin (OCN) in examined. We next examined...
Sanghuang (Sanghuangporus sanghuang, SS) is a medicinal fungus with multiple pharmacological effects, including antioxidant, anti-inflammatory, immune-boosting, and anti-cancer activities. 5-fluorouracil (5-FU) commonly used chemotherapeutic agent for the treatment of colorectal cancer. It primarily exerts its antitumor effect by inhibiting DNA RNA synthesis, leading to cell apoptosis. However, it frequently induces adverse effects These issues limit clinical application 5-FU. This research...
Macrophage M2 polarization plays a critical role in type 2 airway inflammation asthma. We previously reported that serine peptidase inhibitor, clade B, member 10 (SERPINB10) promotes eosinophilic To investigate the of SERPINB10 macrophage and The expression was detected bronchoalveolar lavage (BAL) cells from 15 control subjects 36 asthma patients. Serpinb10 knockout mice wild were sensitized challenged with ovalbumin (OVA). evaluated. An adoptive transfer experiment Serpinb10-deficient...
Background: Asthma is a heterogeneous disease with different subtypes including eosinophilic asthma (EA) and neutrophilic (NA). However, the mechanisms underlying difference between two are not fully understood. Methods: Microarray datasets (GSE45111 GSE137268) were acquired from Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) in induced sputum EA (n = 24) NA 15) identified by "Limma" package. Ontology (GO) Kyoto Encyclopedia of Genes Genomes (KEGG) pathway...