A5100358492- Prostate Cancer Treatment and Research
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Osteoarthritis Treatment and Mechanisms
- Cervical and Thoracic Myelopathy
- Estrogen and related hormone effects
- Complex Network Analysis Techniques
- Pregnancy-related medical research
- S100 Proteins and Annexins
- Adrenal and Paraganglionic Tumors
- Mesenchymal stem cell research
- Hormonal Regulation and Hypertension
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Scoliosis diagnosis and treatment
- Invertebrate Immune Response Mechanisms
- Wnt/β-catenin signaling in development and cancer
- Renal and Vascular Pathologies
- Medical Imaging and Pathology Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Adipose Tissue and Metabolism
- Cancer Genomics and Diagnostics
- Atherosclerosis and Cardiovascular Diseases
- Vascular anomalies and interventions
- Sirtuins and Resveratrol in Medicine
First Affiliated Hospital of Chengdu Medical College
2019-2024
Chengdu Medical College
2024
Tulane University
2014-2024
Sun Yat-sen University
2021-2024
Sun Yat-sen Memorial Hospital
2021-2024
First Affiliated Hospital of Hebei Medical University
2020-2023
Hebei University
2014-2023
Hebei Medical University
2017-2023
Guangzhou Experimental Station
2023
South China University of Technology
2023
The purpose of this study was to explore incidence and risk factors adjacent segment disease (ASD) following posterior decompression instrumented fusion for degenerative lumbar disorders, hope provide references in decision making surgical planning both spinal surgeon surgically treated patients. By retrieving the medical records from January 2011 December 2013 our hospital, 237 patients were retrospectively reviewed. According occurrence ASD at follow up, divided into 2 groups: N-ASD group....
Abstract Cartilage‐derived mesenchymal stem cells (MSCs) have been isolated with different methods. In this study lateral and medial femoral condyles were respectively collected from patients late‐stage osteoarthritis during the total knee arthroplasty. After digestion of cartilage tissues type II collagenase analysis by fluorescence‐activated cell sorting (FACS) CD146, a chondroprogenitor sub‐population purified. The expression other MSC‐associated markers in CD146 + chondroprogenitors was...
Purpose: Advanced prostate cancer (PCa) has limited treatment regimens and shows low response to chemotherapy immunotherapy, leading poor prognosis. Histone modification is a vital mechanism of gene expression promising therapy target. In this study, we characterized WD repeat domain 5 (WDR5), regulator histone modification, explored its potential therapeutic value in PCa. Experimental Design: We specific regulators based on TCGA data. The clinical features WDR5 were analyzed two dependent...
BACKGROUND Interleukin‐17 (IL‐17) has been demonstrated to promote formation and growth of hormone‐naïve prostate adenocarcinoma in mice. IL‐17's role development castration‐resistant cancer is unknown. In the present study, we investigated a mouse model. METHODS IL‐17 receptor C (IL‐17RC) deficient mice were interbred with Pten conditional mutant produce RC + that maintained IL‐17RC expression − deficient. Male ‐null castrated at 16 weeks age when invasive had already formed. At 30 age, all...
To establish an Alzheimer's disease (AD) mouse model, investigate the behavioral performance changes and intracerebral molecular induced by bilateral intracerebroventricular injection of streptozotocin (STZ/I.C.V), explore potential pathogenesis AD. An AD model was established STZ/I.C.V. The observed via open field test (OFT), novel object recognition (NOR), tail suspension (TST). mRNA protein expressions interleukin 1β (IL-1β), 6 (IL-6), tumor necrosis factor α (TNF-α) in hippocampus were...
Hydroxysafflor yellow A (HSYA), an effective ingredient of the Chinese herb Carthamus tinctorius L, attenuated bleomycin-induced pulmonary fibrosis in mice. This study is to investigate effect HSYA on proliferation and inflammatory level human fetal lung fibroblasts (MRC-5 cells) induced by tumor necrosis factor-α (TNF-α) explore underlying mechanisms.MRC-5 cells were treated with different concentrations TNF-α, HSYA, or/and etanercept (ENCP, TNF-α receptor (TNFR1) antagonist, 500 ng/mL)...
ABSTRACT Purpose: Low back pain is a global health problem in which more than 40% caused by lumbar intervertebral disc degeneration (LDD). ADAMTS‐5 (A disintegrin and metalloproteinase with thrombospondin motifs‐5) was shown to be involved LDD functional analyses. To identify whether there an association between LDD, what the contribution of genetic polymorphisms MD (Mean diffusivity) changes IVD (Intervertebral disc). We firstly genotyped selected SNPs (Single nucleotide polymorphisms)...
Abstract Radiotherapy is a curative arsenal for prostate cancer (PCa), but radioresistance seriously compromises its effectiveness. Dysregulated RNA splicing factors are extensively involved in tumor progression. Nonetheless, the role of remains largely unexplored PCa. Here, 23 that differentially expressed between PCa and adjacent normal tissues across multiple public databases identified. Among those genes, polypyrimidine tract binding protein 1 (PTBP1) significantly upregulated positively...
The aim of this study was to explore the prevalence and risk factors for axial neck pain in patients undergoing multilevel anterior cervical decompression with fusion surgery. In study, 88 patients, who underwent surgery from January 2012 2017, were retrospectively reviewed. Based on postoperative pain, classified into two groups: group no group. followed up 3 weeks, months, 1 year after early- long-term clinical evaluation. possible effect included demographic variables (age, sex, BMI,...
Intervertebral disc degeneration (IVDD) is the main pathological basis of spinal degenerative diseases, and aberrant apoptosis nucleus pulposus cells (NPCs) cellular process that causes IVDD. In our previous studies, 17β‑estradiol (E2) was demonstrated to protect rat NPCs from interleukin‑1β (IL‑1β)‑induced via PI3K/Akt signaling pathway. However, downstream pathway currently unclear. The present study aimed explore pathways are pathway, including mTOR, NF‑κB glycogen synthase kinase‑3β...
Prostate cancer (PCa) is associated with advanced age, but how age contributes to prostate carcinogenesis remains unknown. The prostate-specific Pten conditional knockout mouse model closely imitates human PCa initiation and progression. To better understand impacts in an experimental model, we have generated a spatially temporally controlled Pten-null murine at different ages (aged vs. non-aged) of adult mice. Here, present protocol inject the Cre-expressing adenovirus luciferin tag,...
In recent years, with the rapid development of lithium-ion battery industry, massive upstream consumption mineral raw materials has led to great crises and challenges in balancing global supply demand. A diversity trading partners can effectively alleviate pressure demand for materials; so, it is particularly important countries find suitable partners. This study takes nine minerals contained main element batteries as research object, international trade data range from 2011 2020. The...
The effects of hydrogen-rich water on PI3K/AKT-mediated apoptosis were studied in rats subjected to myocardial ischemia-reperfusion injury (MIRI). Methdos: Sixty divided randomly into a group and control group. hearts removed fixed Langendorff device. Hearts from the perfused with K-R solution, was solution + water. two treatment groups then pre-ischemic period, ischemic period reperfusion groups(10 per group), which reverse perfusion for 10 min, normal 20 respectively. mRNA protein...
The Tiaopi Huxin recipe (TPHXR) is widely used in traditional Chinese medicine for the clinical treatment of coronary heart disease. However, mechanism TPHXR atherosclerosis (AS) has not been fully elucidated. In this study, we have aimed to explore potential antiatherosclerotic effect and its underlying mechanisms. Male ApoE knockout (ApoE-/- ) mice were fed a high-fat diet 12 weeks randomly divided into four groups: control group, low-dose, medium-dose, high-dose groups. nitric oxide (NO)...
HTO has proven to be a cost-effective surgical procedure in the treatment of KOA, but few investigations have studied radiological changes and clinical effectiveness OWHTO geriatric patients. 76 patients were recruited this retrospective study. According age, divided into two groups (≤ 60, Group "Young"; > "Geriatric"). Demographic data, imaging postoperative complications analyzed. Kellgren-Lawrence grade (K-L), weight-bearing line ratio (WBLR); posterior tibial slope angle (PTS); American...
Adrenal vein sampling (AVS) is an established procedure for assessing subtype patients with primary aldosteronism (PA). However, it technically challenging, high failure rates, which limits its application in clinical practice. Our study aimed to evaluate the safety and efficacy of a single-catheter modified approach AVS.The clinical, angiographic, procedural data 182 consecutive who underwent AVS procedures between May 2020 2023 were collected analyzed. The was performed as single 5 F Tiger...