A5100450244- Osteoarthritis Treatment and Mechanisms
- Acupuncture Treatment Research Studies
- Healthcare and Venom Research
- Spondyloarthritis Studies and Treatments
- Endometriosis Research and Treatment
- Pelvic floor disorders treatments
- Myofascial pain diagnosis and treatment
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Nerve Injury and Rehabilitation
- Intraocular Surgery and Lenses
- Rheumatoid Arthritis Research and Therapies
- Trigeminal Neuralgia and Treatments
- Urological Disorders and Treatments
- Pregnancy-related medical research
- GDF15 and Related Biomarkers
- Musculoskeletal pain and rehabilitation
- Nuclear Receptors and Signaling
- Psoriasis: Treatment and Pathogenesis
- Uterine Myomas and Treatments
- RNA regulation and disease
- Genital Health and Disease
- Peripheral Nerve Disorders
- Facial Nerve Paralysis Treatment and Research
- Therapeutic Uses of Natural Elements
- Ophthalmology and Visual Impairment Studies
Jiangxi University of Traditional Chinese Medicine
2014-2024
Wuhan Puai Hospital
2024
AbbVie (United States)
2023-2024
Fujian University of Traditional Chinese Medicine
2018-2022
Zhongnan Hospital of Wuhan University
2021-2022
Wuhan University
2021-2022
Guangdong Pharmaceutical University
2022
Huashan Hospital
2021
Fudan University
2021
Weatherford College
2020-2021
Abstract Osteoarthritis (OA) is significantly associated with diabetes, but how hyperglycemia induces or aggravates OA has not been shown. The synovium plays a critical role in cartilage metabolism and substance exchange. Herein, we intended to investigate whether affects the occurrence progression of by influencing synovium. In patients knee diabetes (DM OA), found more severe inflammatory response, higher endoplasmic reticulum stress (ERS) levels, advanced glycosylation end products (AGEs)...
Abstract Cartilage‐derived mesenchymal stem cells (MSCs) have been isolated with different methods. In this study lateral and medial femoral condyles were respectively collected from patients late‐stage osteoarthritis during the total knee arthroplasty. After digestion of cartilage tissues type II collagenase analysis by fluorescence‐activated cell sorting (FACS) CD146, a chondroprogenitor sub‐population purified. The expression other MSC‐associated markers in CD146 + chondroprogenitors was...
Abstract Aim Characterize Growth Differentiation Factor 15 (GDF15) as a secreted biomarker of the integrated stress response (ISR) within central nervous system (CNS). Methods We determined GDF15 levels utilizing in vitro and vivo neuronal systems wherein ISR was activated. Primarily, we used murine model vanishing white matter disease (VWMD), neurological driven by persistent CNS, to establish link between cerebrospinal fluid (CSF) gene expression signature CNS. also CSF VWM patients....
To increase the intra-articular (IA) retention time of osteoarthritis drugs in synovial cavity and slow down burst release microspheres (MPs), we prepared a novel drug delivery system named nanoparticles-in-microspheres (NiMs). The was constructed by dispersing brucine-loaded nanoparticle, which an emulsification method MPs. NiMs were characterized scanning electron microscope, Fourier transform infrared spectra differential calorimetry. After investigating biocompatibility with synovium...
Osteoarthritis (OA) is a chronic arthropathy that occurs in the middle‑aged and elderly population. The present study aimed to identify gene signature differences between synovial cells from OA membrane with without inflammation, explain potential mechanisms involved. differentially expressed genes (DEGs) 12 inflammation dataset GSE46750 were identified using Gene Expression Omnibus 2R. DEGs subjected enrichment analysis, protein‑protein interaction (PPI) analysis module analysis. results...
To estimate the impact of elagolix on work loss due to endometriosis-associated pain.Post hoc analysis data from Elaris I and II clinical trials.Not applicable.Employed women ages 18-49 years with moderate-to-severe pain.In two trials, participants were randomized 6 months treatment placebo, 150 mg once a day, or 200 twice day.Data planned hours, presenteeism, absenteeism, total (absenteeism + presenteeism) at baseline month 3 collected using Health-Related Productivity Questionnaire.This...
Ankylosing spondylitis is a progressive, disabling joint disease that affects millions worldwide. Given its unclear etiology, studies of ankylosing relied heavily on drug-induced or transgenic rodent models which retain only partial clinical features. There obviously lack useful model to conduct comprehensive mechanistic studies.We followed group cynomolgus monkeys having lesions reported spinal stiffness for 2 years by conducting hematological testing, radiographic examination, family...
In patients with congenital blindness (CB), the lack of any visual experience may affect brain development resulting in functional, structural, or even psychological changes. Few studies to date have addressed focused on synchronicity regional activity CB. Our study aimed investigate CB a resting state and try explain possible causes effects anomalies. Twenty-three 23 healthy control (HC) volunteers agreed undergo functional magnetic resonance imaging (fMRI) scans. After fMRI data were...
Rongjin Niantong Fang (RJNTF) is a Traditional Chinese Medicine formulation with good therapeutic effect on osteoarthritis (OA). However, the underlying mechanisms remain unclear.This study investigates whether RJNTF could delay OA cartilage degeneration by regulating SDF-1/CXCR4-p38MAPK signalling pathway.The Sprague-Dawley (SD) rats were used to establish model modified Hulth's method. SD divided into three groups (n = 10): blank group, group (0.9% saline, 10 mL/kg/day), and treatment...
Objective: Endometriosis impacts health-related quality of life. The objective was to assess the validity and responsiveness Health-Related Productivity Questionnaire, version 2 (HRPQ). Methods: Outcome measures (Endometriosis Health Profile-30; pain scales; global assessment) from Elaris I II clinical trials (EM-I, EM-II) were used. Validity testing using Cohen's conventions assessed. Known-groups evaluated generalized linear models comparing responders, assessment change, endometriosis...
Abstract Background: Low back pain is a common clinical chronic disease with symptoms of soreness, numbness, and pain. The incidence low high, gradually increases age. It mainly middle-aged has high recurrence rate. considered to be one the diseases highest disability aim this systematic review assess effectiveness safety moxibustion therapy for Methods: Two reviewers will electronically search following databases: Cochrane Central Register Controlled Trials (CENTRAL);PubMed; EMBASE; China...
Background The causal genetic relationship between common parenteral manifestations of inflammatory bowel disease (IBD) and urolithiasis remains unclear because their timing is difficult to determine. This study investigated the association IBD using Mendelian randomization (MR) based on data from large population-based genome-wide studies (GWASs). Methods A two-sample MR analysis was performed assess potential urolithiasis. Specific single nucleotide polymorphism were obtained GWASs,...
Ankylosing spondylitis is a complex and progressive autoimmune inflammatory disease with worldwide prevalence ranging up to 0.9%. Several systematic reviews meta-analyses of traditional Chinese medicine alternative therapies, such as acupuncture or moxibustion, have demonstrated the effectiveness moxibustion in treatment ankylosing spondylitis. However, there no relevant literature comprehensively evaluate evidence. The purpose this overview synthesize reliability evidence generated review...
Piriformis syndrome (PS) is a condition in which the sciatic nerve compressed when passing through inferior mouth of piriformis muscle, mainly caused by pain one hip and leg. In severe cases, patients may experience buttock lower limb pain, discomfort, difficulty walking, claudication. It estimated that annual incidence low back sciatica about 40 million 2.4 cases. The aim this systematic review to assess effectiveness safety Little needle-scalpel therapy for syndrome.Two reviewers will...
Ganglion cysts (GCs) are tumor-like lesions that often occur in the soft tissues, which mostly caused by degeneration of mucin produced joint capsule and tendon sheath on carpal dorsal joints extremities. GCs may appear asymptomatic as benign tumors, but some patients also seek treatment because pain these fluid-filled cysts. As a kind complementary alternative therapy, there have been studies published China proved fire needle has better therapeutic effect ganglion cyst. The purpose this...
Background: Peripheral facial paralysis (PFP) seriously affects patients' quality of life and work even causes psychological problems such as anxiety depression for them. Acupuncture (ACU) moxibustion have been widely used to treat the disease with satisfactory results. Several systematic reviews meta-analyses reported effectiveness acupuncture patients PFP. However, evidence has not systematically synthesized. This overview aims synthesize assess reliability generated from these (SRs) ACU...
Abstract Background: There is a lack of curative medical treatment for patients with knee osteoarthritis (KOA). Acupuncture represents an important alternative therapy. In various forms acupuncture and moxibustion, the fire needle indispensable part. Knee (KOA) series symptoms signs joint caused by local injury inflammation chronic strain resulting in cartilage degeneration articular surface reactive bone loss subchondral plate. The results clinical trial indicated that therapy has obvious...
Myofascitis is a common disease in clinic. The main cause of the aseptic inflammation local muscles and connective tissues such as myofascial, which can be manifested paralysis, distension, other discomfort, muscle stiffness, spasm or palpable strain-like nodules. Chinese medicine ascribes it to "bi disease" "Arthralgia disease," while Western believes that mainly due fascia edema exudation caused by trauma long-term strain, forcing nerves jam producing pain abnormal feelings. Although not...
Background: Primary dysmenorrhea (PD) occurs during menstrual cramps, and there is currently no pathological evidence. This disease severely affects the daily lives of young women. Acupuncture (ACU) moxibustion are an excellent way to relieve pain patients with PD. And it has been widely utilizing. However, effectiveness safety ACU in treating PD not confirmed by a high-quality meta-analysis. work aims evaluate ACU's efficacy or without management Methods: We will make comprehensive...
Alopecia areata (AA) is a common, inflammatory, nonscarring type of hair loss that characterized by depression, anxiety and social isolation. In recent years, Plum-blossom needle plus Chinese herbal medicine has gradually shown its clinical advantages been more widely used in China. Whereas, there no systematic review meta-analysis. The purpose this study to estimate the safety effectiveness AA treatment.Seven databases as following: PubMed, Embase, Cochrane Library, China National Knowledge...