Melanie Hakar

ORCID: 0000-0003-1106-028X
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About
Contact & Profiles
Research Areas
  • Sarcoma Diagnosis and Treatment
  • Bone Tumor Diagnosis and Treatments
  • Glioma Diagnosis and Treatment
  • Meningioma and schwannoma management
  • Cardiac tumors and thrombi
  • Neuroblastoma Research and Treatments
  • Cardiovascular Effects of Exercise
  • Cardiac Structural Anomalies and Repair
  • Cannabis and Cannabinoid Research
  • Dysphagia Assessment and Management
  • Liver Diseases and Immunity
  • Vascular Tumors and Angiosarcomas
  • Oral and Maxillofacial Pathology
  • Fetal and Pediatric Neurological Disorders
  • Liver Disease Diagnosis and Treatment
  • DNA Repair Mechanisms
  • Neonatal and fetal brain pathology
  • Polyomavirus and related diseases
  • Urological Disorders and Treatments
  • Prenatal Substance Exposure Effects
  • Vascular Malformations and Hemangiomas
  • Carcinogens and Genotoxicity Assessment
  • Gastrointestinal disorders and treatments
  • Cancer-related Molecular Pathways
  • Pediatric Hepatobiliary Diseases and Treatments

Oregon Health & Science University
2020-2024

Abstract Prenatal cannabis use is associated with adverse offspring neurodevelopmental outcomes, however the underlying mechanisms are relatively unknown. We sought to determine impact of chronic delta-9-tetrahydrocannabinol (THC) exposure on fetal neurodevelopment in a rhesus macaque model using advanced imaging combined molecular and tissue studies. Animals were divided into two groups, control (n = 5) THC-exposed 5), which received daily THC edible pre-conception throughout pregnancy....

10.1038/s41598-024-56386-7 article EN cc-by Scientific Reports 2024-03-09

ABSTRACT Objective The objective of this study is to evaluate outcomes fetal sacrococcygeal teratoma (SCT) from an academic tertiary center. Study Design This a retrospective evaluating pregnancy and postnatal SCT management at single institution between 2006 2023. Results are reported as median (range). Fourteen patients with were studied. Hydrops fetalis occurred in 2 (14.3%) cases. Pregnancy course included expectant 12 (85.7%) palliative preterm induction 1 patient (7.1%). Indications...

10.1002/bdr2.2405 article EN Birth Defects Research 2024-10-01

Nijmegen Breakage Syndrome (NBS) is a rare autosomal recessive DNA repair disorder that increases risk of hematological malignancy. Primary gastric malignancies are exceedingly in pediatric patients and not typically high on the differential abdominal pain.A 14-year-old male with NBS presented persistent pain was diagnosed primary Hodgkin disease stomach.In predisposition to malignancies, such as those underlying chromosome instability disorders, all symptoms must be carefully considered.

10.1186/s12887-023-03929-y article EN cc-by BMC Pediatrics 2023-04-21

Myxopapillary ependymomas (MPEs) are rare spinal cord tumors with low rates of metastasis outside the neuraxis. Gross total resection MPEs can significantly improve progression-free survival; however, adjunctive treatment remains unstandardized. A 29-year-old female a history spina bifida occulta surgical correction and lower back pain presented dyspnea tachycardia. large pulmonary artery mass was discovered consistent thromboembolism. It subsequently determined to be an intravascular...

10.1055/s-0044-1779293 article EN cc-by-nc-nd Asian Journal of Neurosurgery 2024-05-27

We present a case of hamartoma mature cardiac myocytes. This is an extremely rare tumour and the first reported paediatric localised in left atrium.

10.1017/s1047951121004972 article EN cc-by Cardiology in the Young 2022-01-10

Abstract Fibrous dysplasia is a dysplastic disorder of bone caused by missense mutations the GNAS1 gene. Fibrocartilaginous (also known as fibrochondrodysplasia or fibrous with extensive cartilaginous differentiation) rare variant differentiation that shows predilection for lower extremities and can affect one multiple bones. Although benign, this entity causes progressively expansile lesions lead to deformity ultimately pathologic fracture. On imaging, show features consistent variety...

10.1097/pcr.0000000000000427 article EN AJSP Review and Reports 2021-01-01

Abstract Objective We describe the first jugular foramen angiomatoid fibrous histiocytoma (AFH) case and treatment with preoperative endovascular embolization. AFH is a rare intracranial neoplasm, primarily found in pediatric patient extremities. With an increase awareness well-described genetic profile, prevalence has also subsequently increased. Study Design compare this to previously reported cases using PubMed/Medline literature search, which was performed algorithm [“intracranial” AND...

10.1055/s-0042-1754320 article EN cc-by-nc-nd Journal of Neurological Surgery Reports 2022-07-01

Anastomotic ulceration is a known complication of short gut syndrome, which can be complicated by concurrent iron deficiency and chronic bleeding. Diagnosis confirmed through endoscopy, typically performed for the investigation severe anemia. Inflammatory colitis in syndrome has been previously reported; therefore, it important to treat both inflammation. Currently, no effective therapies are available. Herein, we describe case child with who subsequently developed anastomotic ulcers...

10.1097/pg9.0000000000000328 article EN cc-by JPGN Reports 2023-06-16
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