A5052526144- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- SARS-CoV-2 and COVID-19 Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Pneumonia and Respiratory Infections
- Flexible and Reconfigurable Manufacturing Systems
- Antimicrobial Resistance in Staphylococcus
- Infective Endocarditis Diagnosis and Management
- Nosocomial Infections in ICU
- Bacterial Identification and Susceptibility Testing
- T-cell and B-cell Immunology
- Bacterial biofilms and quorum sensing
- Vector-borne infectious diseases
- COVID-19 Clinical Research Studies
- Streptococcal Infections and Treatments
- Mosquito-borne diseases and control
- Heparin-Induced Thrombocytopenia and Thrombosis
- Urinary Tract Infections Management
- SARS-CoV-2 detection and testing
- Gallbladder and Bile Duct Disorders
- Cystic Fibrosis Research Advances
- Pediatric Urology and Nephrology Studies
- Neonatal and Maternal Infections
- Business Process Modeling and Analysis
- Plant Pathogens and Fungal Diseases
Universitätsklinikum Erlangen
2015-2025
Friedrich-Alexander-Universität Erlangen-Nürnberg
2015-2025
Medizinische Hochschule Hannover
2024
University of Design Schwäbisch Gmünd
2019
Institute of Medical Microbiology and Hygiene
2013-2018
University Medical Center Freiburg
2010-2018
University of Freiburg
2010-2018
University of Graz
2014
World Health Organization - Pakistan
2010
Heinrich Heine University Düsseldorf
2003
RNA vaccines are efficient preventive measures to combat the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. High levels of neutralizing SARS-CoV-2 antibodies an important component vaccine-induced immunity. Shortly after initial two mRNA vaccine doses, immunoglobulin G (IgG) response mainly consists proinflammatory subclasses IgG1 and IgG3. Here, we report that several months second vaccination, SARS-CoV-2–specific were increasingly composed noninflammatory IgG4,...
Since the mid-1990s, a steady increase in occurrence of itraconazole-resistant Aspergillus fumigatus isolates has been observed clinical contexts, leading to therapeutic failure treatment aspergillosis. This predominantly linked single allele cyp51A gene, termed TR/L98H, which is thought have arisen through use agricultural azoles. Here, we investigated current epidemiology triazole-resistant A. and underlying mutations samples Germany. From total 527 samples, 17 (3.2%) showed elevated MIC0...
Background. Recent population-based cohort studies have questioned the role of pneumococci as most frequent pathogen causing severe infection in patients after splenectomy. The aim study was to define causative pathogens and clinical presentation with overwhelming postsplenectomy (OPSI). Methods. In a prospective 173 German intensive care units, we searched for without asplenia community-acquired sepsis/septic shock. Clinical laboratory variables survival were assessed. Results. Fifty-two...
Hepatitis C virus (HCV) infection is a major cause of liver disease characterized by inflammation, cell damage, and fibrotic reactions hepatocytes. Apoptosis has been implicated in the pathogenesis, although it unclear whether proteases caspase family as central executioners apoptosis are involved how activation contributes to injury. In present study, we measured effector caspases biopsy specimens patients with chronic HCV infection. The caspase-3, caspase-7, cleavage...
ABSTRACT We conducted a case-control study using the Fungitell assay, novel Platelia Candida Antigen (Ag) Plus and Antibody (Ab) assays, Cand-Tec latex agglutination test to evaluate usefulness of (1→3)-β- d -glucan (BDG), mannan antigen with/without anti-mannan antibody, measurement for diagnosis candidemia. A total 56 patients fulfilled inclusion criteria were enrolled. One hundred with bacteremia 100 sterile blood cultures served as negative controls. In candidemia group, median -glucan,...
To investigate whether (1 → 3)-β-d-Glucan (BDG)-guidance shortens time to antifungal therapy and thereby reduces mortality of sepsis patients with high risk invasive Candida infection (ICI). Multicenter, randomized, controlled trial carried out between September 2016 2019 in 18 intensive care units enrolling adult at for ICI. Patients the control group received targeted driven by culture results. In addition therapy, BDG antifungals if least one two consecutive samples taken during first...
Mayaro virus is endemic in South America and sporadic outbreaks have been described. It causes a dengue-like febrile illness accompanied by severe long-lasting polyarthralgias. Outside regions, however, the disease not well known can be misdiagnosed as dengue. International travellers are at risk to acquire due increased worldwide travel infectious specialists need aware of such rare clinical entities. We report first infection imported into Germany. A 20-year-old woman developed fever,...
(1→3)-β-d-Glucan (BDG) is a biomarker for invasive fungal disease. Until now, all BDG data in the Western Hemisphere were obtained using Fungitell assay (FA). How it compares to Wako β-glucan test (GT), which was recently launched Europe, largely unknown. We conducted case-control study compare two assays serum samples from 120 candidemia and 63 Pneumocystis jirovecii pneumonia (PCP) patients. Two hundred patients with bacteremia or negative blood cultures served as control group. In median...
mRNA vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), such as BNT162b2 (Comirnaty®), have proven to be highly immunogenic and efficient but also show marked reactogenicity, leading adverse effects (AEs). Here, we analyzed whether the severity of AEs predicts antibody response SARS-CoV-2 spike protein. Healthcare workers without prior infection, who received a prime-boost vaccination with BNT162b2, completed standardized electronic questionnaire on duration AEs....
Incorrect diagnosis of photoallergy to sunscreen products represents a unique clinical dilemma. Increasing usage for suspected idiopathic photosensitivity or change containing the same photoallergen only worsens problem. While p-aminobenzoic acid and its esters is well known by dermatologists lay public, benzophenone not appreciated. We report herein cases four individuals with oxybenzone in sunscreens. It likely that such reactions will become more commonplace since far most frequently used...
Adequate and timely antibiotic therapy is crucial for the treatment of sepsis. Innovative systems, like Q-linea ASTar, have been developed to perform rapid antimicrobial susceptibility testing (AST) directly from positive blood cultures (BCs). We conducted a prospective study evaluate ASTar under real-life conditions with focus on time-to-result impact therapy. Over 2 months, all BCs that showed Gram-negative rods upon microscopy were tested our standard procedure (VITEK short-term culture)....
Macrophage migration inhibitory factor (MIF) displays both cytokine and enzyme activities, but its molecular mode of action is still unclear. MIF contains three cysteine residues we showed recently that the conserved Cys57‐Ala‐Leu‐Cys60 (CALC) motif critical for oxidoreductase macrophage‐activating activities MIF. Here probed further role this catalytic centre by expression, purification, characterization cysteine→serine mutants Cys60Ser, Cys57Ser/Cys60Ser, Cys81Ser human Ala58Gly/Leu59Pro...
Abstract Paenibacillus larvae causes American foulbrood in honey bees. We describe P. bacteremia 5 injection drug users who had self-injected honey-prepared methadone proven to contain spores. That such preparations may be contaminated with spores of this organism is not well known among pharmacists, physicians, and addicts.
Rapid galactomannan tests, such as the sõna Aspergillus GM Lateral Flow Assay (GM-LFA) and Galactomannan Ag VIRCLIA® Monotest (GM-Monotest), which are suitable for analysis of single samples, have potential to accelerate diagnosis invasive aspergillosis (IA).
A commercially available loop-mediated isothermal amplification assay (LAMP) for the detection of Pneumocystis jirovecii (P. jirovecii) has been evaluated diagnosis pneumonia (PcP) in critically ill patients. Altogether, 109 lower respiratory tract specimens from 95 patients with a positive P. test routine diagnostics were collected five distinct university hospitals Germany. All samples tested qPCR and eazyplex® LAMP assay. was set as gold standard beforehand 100 categorized to have proven,...